Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

• Published in: Nature medicine Vol. 13; no. 8; pp. 913 - 919
• Main Authors: Idzko, Marco, Hammad, Hamida, van Nimwegen, Menno, Kool, Mirjam, Willart, Monique A M, Muskens, Femke, Hoogsteden, Henk C, Luttmann, Werner, Ferrari, Davide, Di Virgilio, Francesco, Virchow, J Christian, Lambrecht, Bart N
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2007; Nature Publishing Group
• Subjects: Adenosine triphosphatase; Adenosine Triphosphate - metabolism; Adenosine Triphosphate - pharmacology; Allergens; Allergies; Animals; Antagonist drugs; Asthma; Asthma - chemically induced; Asthma - immunology; Asthma - metabolism; Asthma - pathology; ATP; Biomedical and Life Sciences; Biomedical research; Biomedicine; Cancer Research; Cell Differentiation; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - immunology; Humans; Immune system; Immunology; Infectious Diseases; Inflammation - chemically induced; Inflammation - immunology; Inflammation - metabolism; Inflammation - pathology; Inflammatory diseases; Lungs; Metabolic Diseases; Mice; Mice, Inbred BALB C; Molecular Medicine; Neurosciences; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2 - metabolism; Suramin - pharmacology; Th2 Cells - drug effects; Th2 Cells - immunology

Extracellular ATP serves as a danger signal to alert the immune system of tissue damage by acting on P2X or P2Y receptors. Here we show that allergen challenge causes acute accumulation of ATP in the airways of asthmatic subjects and mice with experimentally induced asthma. All the cardinal features...