Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

• Published in: Aging cell Vol. 19; no. 8; pp. e13195 - n/a
• Main Authors: Moon, Ji Sun, Goeminne, Ludger J. E., Kim, Jung Tae, Tian, Jing Wen, Kim, Seok‐Hwan, Nga, Ha Thi, Kang, Seul Gi, Kang, Baeki E., Byun, Jin‐Seok, Lee, Young‐Sun, Jeon, Jae‐Han, Shong, Minho, Auwerx, Johan, Ryu, Dongryeol, Yi, Hyon‐Seung
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2020; John Wiley and Sons Inc
• Subjects: Adipose tissue; Age; Aging; Aging - physiology; Animals; Body weight; Cell activation; Cell differentiation; Chronic illnesses; Cytokines; Datasets; Deoxyribonucleic acid; Diabetes; Diabetes mellitus (non-insulin dependent); Disease; DNA; Female; Geriatrics; Growth; Growth Differentiation Factor 15 - metabolism; Helper cells; Homeostasis; Humans; Inflammation; Inflammation - metabolism; Inflammation - pathology; Insulin; Insulin resistance; Kinases; Liver; Lymphocytes; Lymphocytes T; Male; Mendelian Randomization Analysis; Metabolic disorders; Metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; mitochondria; Mitochondrial DNA; Older people; Original Paper; Phosphorylation; Plasma; senescence; Serum levels; T cell; T cells; Type 2 diabetes; senescence; aging; inflammation; T cell; mitochondria

Mitochondrial dysfunction is associated with aging‐mediated inflammatory responses, leading to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth differentiation factor 15 (GDF15) is an important mitokine generated in response to mitochondrial stress and dysfunct...