DREAM Controls the On/Off Switch of Specific Activity-Dependent Transcription Pathways

OA  Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inMolecular and Cellular Biology Vol. 34; no. 5; pp. 877 - 887
Main Authors Mellström, Britt, Sahún, Ignasi, Ruiz-Nuño, Ana, Murtra, Patricia, Gomez-Villafuertes, Rosa, Savignac, Magali, Oliveros, Juan C., Gonzalez, Paz, Kastanauskaite, Asta, Knafo, Shira, Zhuo, Min, Higuera-Matas, Alejandro, Errington, Michael L., Maldonado, Rafael, DeFelipe, Javier, Jefferys, John G. R., Bliss, Tim V. P., Dierssen, Mara, Naranjo, Jose R.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.03.2014
Taylor & Francis
Subjects
Animals
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
Calcium - metabolism
Cells, Cultured
Cervell
Cyclic AMP Response Element-Binding Protein - genetics
Cyclic AMP Response Element-Binding Protein - metabolism
Dentate Gyrus - metabolism
Down-Regulation - genetics
GABAergic Neurons - metabolism
Genètica
Hippocampus - metabolism
Kv Channel-Interacting Proteins - genetics
Kv Channel-Interacting Proteins - metabolism
Learning
Mice
Mice, Transgenic
Promoter Regions, Genetic - genetics
Prosencephalon - metabolism
Proteïnes
Repressor Proteins - genetics
Repressor Proteins - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic - genetics
Online AccessGet full text

Cover

Abstract OA  Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
AbstractList Changes in nuclear Ca(2+) homeostasis activate specific gene expression programs and are central to the acquisition and storage of information in the brain. DREAM (downstream regulatory element antagonist modulator), also known as calsenilin/KChIP-3 (K(+) channel interacting protein 3), is a Ca(2+)-binding protein that binds DNA and represses transcription in a Ca(2+)-dependent manner. To study the function of DREAM in the brain, we used transgenic mice expressing a Ca(2+)-insensitive/CREB-independent dominant active mutant DREAM (daDREAM). Using genome-wide analysis, we show that DREAM regulates the expression of specific activity-dependent transcription factors in the hippocampus, including Npas4, Nr4a1, Mef2c, JunB, and c-Fos. Furthermore, DREAM regulates its own expression, establishing an autoinhibitory feedback loop to terminate activity-dependent transcription. Ablation of DREAM does not modify activity-dependent transcription because of gene compensation by the other KChIP family members. The expression of daDREAM in the forebrain resulted in a complex phenotype characterized by loss of recurrent inhibition and enhanced long-term potentiation (LTP) in the dentate gyrus and impaired learning and memory. Our results indicate that DREAM is a major master switch transcription factor that regulates the on/off status of specific activity-dependent gene expression programs that control synaptic plasticity, learning, and memory.
OA  Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
Changes in nuclear Ca(2+) homeostasis activate specific gene expression programs and are central to the acquisition and storage of information in the brain. DREAM (downstream regulatory element antagonist modulator), also known as calsenilin/KChIP-3 (K(+) channel interacting protein 3), is a Ca(2+)-binding protein that binds DNA and represses transcription in a Ca(2+)-dependent manner. To study the function of DREAM in the brain, we used transgenic mice expressing a Ca(2+)-insensitive/CREB-independent dominant active mutant DREAM (daDREAM). Using genome-wide analysis, we show that DREAM regulates the expression of specific activity-dependent transcription factors in the hippocampus, including Npas4, Nr4a1, Mef2c, JunB, and c-Fos. Furthermore, DREAM regulates its own expression, establishing an autoinhibitory feedback loop to terminate activity-dependent transcription. Ablation of DREAM does not modify activity-dependent transcription because of gene compensation by the other KChIP family members. The expression of daDREAM in the forebrain resulted in a complex phenotype characterized by loss of recurrent inhibition and enhanced long-term potentiation (LTP) in the dentate gyrus and impaired learning and memory. Our results indicate that DREAM is a major master switch transcription factor that regulates the on/off status of specific activity-dependent gene expression programs that control synaptic plasticity, learning, and memory. This work was supported by grants from Spanish Ministry of Health and Science, Madrid Community, La Marató, La Caixa, Reina Sofía and Areces Foundations, the EU 6th Framework Program (NeuroNE, CureFXS), the ERA-NET Program (Neuron and E-Rare), and the Medical Research Council. S.K. has a postdoctoral contract from the Ramón y Cajal Program of the Ministry of Science and Innovation.
Changes in nuclear Ca 2+ homeostasis activate specific gene expression programs and are central to the acquisition and storage of information in the brain. DREAM ( d ownstream r egulatory e lement a ntagonist m odulator), also known as calsenilin/KChIP-3 ( K + ch annel i nteracting p rotein 3), is a Ca 2+ -binding protein that binds DNA and represses transcription in a Ca 2+ -dependent manner. To study the function of DREAM in the brain, we used transgenic mice expressing a Ca 2+ -insensitive/CREB-independent dominant active mutant DREAM (daDREAM). Using genome-wide analysis, we show that DREAM regulates the expression of specific activity-dependent transcription factors in the hippocampus, including Npas4, Nr4a1, Mef2c, JunB, and c-Fos. Furthermore, DREAM regulates its own expression, establishing an autoinhibitory feedback loop to terminate activity-dependent transcription. Ablation of DREAM does not modify activity-dependent transcription because of gene compensation by the other KChIP family members. The expression of daDREAM in the forebrain resulted in a complex phenotype characterized by loss of recurrent inhibition and enhanced long-term potentiation (LTP) in the dentate gyrus and impaired learning and memory. Our results indicate that DREAM is a major master switch transcription factor that regulates the on/off status of specific activity-dependent gene expression programs that control synaptic plasticity, learning, and memory.
Author Michael L. Errington
Jose R. Naranjo
Alejandro Higuera-Matas
Rosa Gomez-Villafuertes
Patricia Murtra
Tim V. P. Bliss
John G. R. Jefferys
Britt Mellström
Ignasi Sahún
Rafael Maldonado
Paz Gonzalez
Asta Kastanauskaite
Ana Ruiz-Nuño
Javier DeFelipe
Magali Savignac
Shira Knafo
Juan C. Oliveros
Min Zhuo
Mara Dierssen
Author_xml – sequence: 1
  givenname: Britt
  surname: Mellström
  fullname: Mellström, Britt
  organization: National Center of Biotechnology, CSIC and CIBERNED
– sequence: 2
  givenname: Ignasi
  surname: Sahún
  fullname: Sahún, Ignasi
  organization: Genomic Regulation Center, PRBB and CIBERER
– sequence: 3
  givenname: Ana
  surname: Ruiz-Nuño
  fullname: Ruiz-Nuño, Ana
  organization: Neuronal Networks Group, School of Clinical and Experimental Medicine, University of Birmingham
– sequence: 4
  givenname: Patricia
  surname: Murtra
  fullname: Murtra, Patricia
  organization: University Pompeu Fabra
– sequence: 5
  givenname: Rosa
  surname: Gomez-Villafuertes
  fullname: Gomez-Villafuertes, Rosa
  organization: National Center of Biotechnology, CSIC and CIBERNED
– sequence: 6
  givenname: Magali
  surname: Savignac
  fullname: Savignac, Magali
  organization: National Center of Biotechnology, CSIC and CIBERNED
– sequence: 7
  givenname: Juan C.
  surname: Oliveros
  fullname: Oliveros, Juan C.
  organization: National Center of Biotechnology, CSIC and CIBERNED
– sequence: 8
  givenname: Paz
  surname: Gonzalez
  fullname: Gonzalez, Paz
  organization: National Center of Biotechnology, CSIC and CIBERNED
– sequence: 9
  givenname: Asta
  surname: Kastanauskaite
  fullname: Kastanauskaite, Asta
  organization: Cajal Institute, CSIC and CIBERNED
– sequence: 10
  givenname: Shira
  surname: Knafo
  fullname: Knafo, Shira
  organization: Cajal Institute, CSIC and CIBERNED
– sequence: 11
  givenname: Min
  surname: Zhuo
  fullname: Zhuo, Min
  organization: Department of Brain and Cognitive Sciences, Seoul National University
– sequence: 12
  givenname: Alejandro
  surname: Higuera-Matas
  fullname: Higuera-Matas, Alejandro
  organization: MRC National Institute for Medical Research, Mill Hill
– sequence: 13
  givenname: Michael L.
  surname: Errington
  fullname: Errington, Michael L.
  organization: MRC National Institute for Medical Research, Mill Hill
– sequence: 14
  givenname: Rafael
  surname: Maldonado
  fullname: Maldonado, Rafael
  organization: University Pompeu Fabra
– sequence: 15
  givenname: Javier
  surname: DeFelipe
  fullname: DeFelipe, Javier
  organization: Cajal Institute, CSIC and CIBERNED
– sequence: 16
  givenname: John G. R.
  surname: Jefferys
  fullname: Jefferys, John G. R.
  organization: Neuronal Networks Group, School of Clinical and Experimental Medicine, University of Birmingham
– sequence: 17
  givenname: Tim V. P.
  surname: Bliss
  fullname: Bliss, Tim V. P.
  organization: MRC National Institute for Medical Research, Mill Hill
– sequence: 18
  givenname: Mara
  surname: Dierssen
  fullname: Dierssen, Mara
  organization: Genomic Regulation Center, PRBB and CIBERER
– sequence: 19
  givenname: Jose R.
  surname: Naranjo
  fullname: Naranjo, Jose R.
  email: naranjo@cnb.csic.es
  organization: National Center of Biotechnology, CSIC and CIBERNED
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24366545$$D View this record in MEDLINE/PubMed
BookMark eNptkU1vEzEYhC1URNPCjTPaIwe2ff256wtSSEuL1CoIClfLcbxdo107tZ1G-fe4TYhA4mDZlmeed6w5QUc-eIvQWwxnGJP2_Hb26QyACqgxfYEmGGRbc87kEZoAaaBuKIhjdJLSLwAQEugrdEwYFYIzPkE_L75dTm-rWfA5hiFVubfV3J_Pu676vnHZ9FUop5U1rnOmmprsHl3e1hd2Zf3S-lzdRe2TiW6VXfDVV537jd6m1-hlp4dk3-z3U_Tj8-Xd7Lq-mV99mU1vaiOgzfXStFx3WBOhsdWcSyubFnNLJeZEyAXhomVcC9paYBoTDqLVXFJtycJ0gtBT9HHHXa0Xo12akijqQa2iG3XcqqCd-vfFu17dh0fFgNCW4gLAO4BJa6OiNTYanZ-Nh8vTItAQRUsqCsXzfj80hoe1TVmNLhk7DNrbsE4KMykxAwZNkX7Y42NIKdruEA2DeqpPlfrUc30K0yJ_9_d3DuI_fRVBsxM434U46k2Iw1JlvR1C7EoTxqWS8v_oaufs3X2_cdEqnUY1moWiTHHVNg39DfvZs9E
CitedBy_id crossref_primary_10_1038_s41598_019_43677_7
crossref_primary_10_1084_jem_20211083
crossref_primary_10_1101_cshperspect_a035287
crossref_primary_10_3389_fnmol_2018_00449
crossref_primary_10_1016_j_neuron_2019_02_007
crossref_primary_10_1038_s41380_023_02311_9
crossref_primary_10_1152_ajplung_00335_2018
crossref_primary_10_4155_ppa_2016_0029
crossref_primary_10_1111_jnc_13572
crossref_primary_10_3389_fnmol_2018_00472
crossref_primary_10_3390_ijms161226144
crossref_primary_10_2139_ssrn_2857935
crossref_primary_10_3390_cells12141894
crossref_primary_10_1016_j_nlm_2014_08_010
crossref_primary_10_1016_j_neuroscience_2014_10_037
crossref_primary_10_1002_pmic_201900028
crossref_primary_10_1016_j_expneurol_2017_12_017
crossref_primary_10_1172_JCI82670
crossref_primary_10_3389_fnmol_2019_00252
crossref_primary_10_1186_s13041_018_0359_6
crossref_primary_10_3389_fnmol_2019_00005
crossref_primary_10_1016_j_clineuro_2020_106397
crossref_primary_10_1111_jnc_13584
crossref_primary_10_3390_ijms24119177
crossref_primary_10_1186_s13041_016_0204_8
crossref_primary_10_1016_j_phrs_2017_01_002
crossref_primary_10_1002_adbi_202300654
Cites_doi 10.1126/science.1122511
10.1126/science.1208049
10.1016/S0167-4889(00)00092-6
10.1101/lm.1261709
10.1128/MCB.24.2.608-616.2004
10.1016/j.ceca.2005.06.013
10.1016/S0092-8674(01)00629-8
10.1097/00001756-199702100-00040
10.1074/jbc.M105842200
10.1007/s00424-007-0238-y
10.1038/386855a0
10.1038/nn1627
10.1523/JNEUROSCI.1661-03.2004
10.1016/j.arr.2004.07.002
10.1523/JNEUROSCI.0776-04.2004
10.1523/JNEUROSCI.4540-10.2011
10.1016/0896-6273(93)90163-L
10.1038/nrn2738
10.1007/0-387-29362-0_23
10.1038/nature12743
10.1523/JNEUROSCI.1460-04.2004
10.1111/j.1528-1167.2009.02217.x
10.1016/j.neuron.2008.09.002
10.1371/journal.pone.0046604
10.1089/ars.2010.3385
10.1152/physrev.00041.2005
10.1126/science.1585183
10.1074/jbc.M500338200
10.1038/31965
10.1038/nn835
10.1038/18044
10.1074/jbc.M403526200
10.1016/S0092-8674(01)00588-8
10.1371/journal.pgen.1000604
10.1615/CritRevNeurobiol.v16.i12.40
10.1038/nature07319
10.1093/emboj/cdf440
10.1016/0006-8993(72)90268-5
10.1038/198540a0
10.1074/jbc.270.51.30245
10.2307/2346101
10.1523/JNEUROSCI.23-27-09097.2003
10.1093/abbs/gmp013
10.1016/j.bbamcr.2010.11.001
10.1186/1744-8069-6-95
10.1093/biostatistics/4.2.249
10.1074/jbc.R112.384982
10.1097/00001756-199407000-00023
10.1101/gad.14.7.804
10.4049/jimmunol.1000152
10.1523/JNEUROSCI.3912-05.2005
10.1186/1756-6606-3-3
10.1038/sj.emboj.7600810
10.1093/bioinformatics/btg405
ContentType Journal Article
Copyright Copyright © 2014, American Society for Microbiology 2014
2014, American Society for Microbiology. All Rights Reserved. doi:10.1128/MCB.00360-13. The authors have paid a fee to allow immediate free access to this article info:eu-repo/semantics/openAccess
Copyright © 2014, American Society for Microbiology. All Rights Reserved. 2014 American Society for Microbiology
Copyright_xml – notice: Copyright © 2014, American Society for Microbiology 2014
– notice: 2014, American Society for Microbiology. All Rights Reserved. doi:10.1128/MCB.00360-13. The authors have paid a fee to allow immediate free access to this article info:eu-repo/semantics/openAccess
– notice: Copyright © 2014, American Society for Microbiology. All Rights Reserved. 2014 American Society for Microbiology
DBID 0YH
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
XX2
5PM
DOI 10.1128/MCB.00360-13
DatabaseName Taylor & Francis_OA刊
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
Recercat
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: 0YH
  name: Taylor & Francis_OA刊
  url: https://www.tandfonline.com
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Biology
EISSN 1098-5549
EndPage 887
ExternalDocumentID oai_recercat_cat_2072_315230
10_1128_MCB_00360_13
24366545
12275120
mcb_34_5_877
Genre Article
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-DZ
-~X
0R~
0YH
123
18M
29M
2WC
39C
4.4
53G
5RE
5VS
AAPBV
ABPTK
ACGFO
ACNCT
ADBBV
ADIYS
AENEX
AGVNZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
GX1
H13
HH5
HYE
HZ~
IH2
KQ8
L7B
N9A
O9-
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TFL
TFW
TR2
UCJ
UDS
VQA
W8F
WH7
WOQ
ZA5
ZCA
.55
.GJ
3O-
9M8
ABJNI
ABRLO
ABTAH
ACKIV
AEOZL
AFFNX
AGHSJ
C1A
CGR
CUY
CVF
ECM
EIF
EMOBN
F20
M4Z
MVM
NPM
TDBHL
WHG
X7M
Y6R
YYP
ZGI
ZXP
ZY4
AAYXX
CITATION
7X8
XX2
5PM
ID FETCH-LOGICAL-c608t-dc85af1a26a1ea559e97815e3915269b256845a638e04a125068a593ae2bcf623
IEDL.DBID RPM
ISSN 0270-7306
1098-5549
IngestDate Tue Sep 17 20:51:11 EDT 2024
Fri Oct 11 12:45:27 EDT 2024
Sun Jul 21 06:25:15 EDT 2024
Thu Sep 12 19:36:45 EDT 2024
Sat Sep 28 08:04:50 EDT 2024
Tue Jun 13 19:24:35 EDT 2023
Wed May 18 15:26:46 EDT 2016
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Language English
License open-access: The authors have paid a fee to allow immediate free access to this article.
The authors have paid a fee to allow immediate free access to this article.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c608t-dc85af1a26a1ea559e97815e3915269b256845a638e04a125068a593ae2bcf623
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
B.M., I.S., A.R.-N., and P.M. contributed equally to the work.
Present address: Shira Knafo, IkerBasque Basque Foundation for Science and BioCruces Health Research Institute, Leioa, Bizkaia, Spain.
OpenAccessLink https://www.tandfonline.com/doi/abs/10.1128/MCB.00360-13
PMID 24366545
PQID 1499140407
PQPubID 23479
PageCount 11
ParticipantIDs crossref_primary_10_1128_MCB_00360_13
highwire_asm_mcb_34_5_877
csuc_recercat_oai_recercat_cat_2072_315230
informaworld_taylorfrancis_310_1128_MCB_00360_13
pubmed_primary_24366545
pubmedcentral_primary_oai_pubmedcentral_nih_gov_4023831
proquest_miscellaneous_1499140407
PublicationCentury 2000
PublicationDate 2014-03-01
PublicationDateYYYYMMDD 2014-03-01
PublicationDate_xml – month: 03
  year: 2014
  text: 2014-03-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: 1752 N St., N.W., Washington, DC
PublicationTitle Molecular and Cellular Biology
PublicationTitleAlternate Mol Cell Biol
PublicationYear 2014
Publisher American Society for Microbiology
Taylor & Francis
Publisher_xml – name: American Society for Microbiology
– name: Taylor & Francis
References 15581398 - Crit Rev Neurobiol. 2004;16(1-2):43-9
9582076 - Nature. 1998 Apr 30;392(6679):936-41
18391169 - Physiol Rev. 2008 Apr;88(2):421-49
24201284 - Nature. 2013 Nov 7;503(7474):121-5
12925520 - Biostatistics. 2003 Apr;4(2):249-64
19223600 - Learn Mem. 2009 Mar;16(3):167-77
15190107 - J Neurosci. 2004 Jun 9;24(23):5346-55
14701734 - Mol Cell Biol. 2004 Jan;24(2):608-16
19927149 - Nat Rev Neurosci. 2009 Dec;10(12):850-60
16177826 - EMBO J. 2005 Oct 19;24(20):3555-64
14715953 - J Neurosci. 2004 Jan 7;24(1):207-17
20205763 - Mol Brain. 2010;3:3
1585183 - Science. 1992 May 1;256(5057):675-7
19682049 - Epilepsia. 2009 Aug;50 Suppl 7:37-42
8476611 - Neuron. 1993 Apr;10(4):599-611
11535596 - J Biol Chem. 2001 Nov 2;276(44):41005-13
9126747 - Nature. 1997 Apr 24;386(6627):855-8
23029555 - PLoS One. 2012;7(9):e46604
8530438 - J Biol Chem. 1995 Dec 22;270(51):30245-8
7948848 - Neuroreport. 1994 Jul 21;5(12):1501-4
10766737 - Genes Dev. 2000 Apr 1;14(7):804-16
11747815 - Cell. 2001 Dec 14;107(6):801-13
21368041 - J Neurosci. 2011 Mar 2;31(9):3295-308
16484497 - Science. 2006 Feb 17;311(5763):1008-12
16415869 - Nat Neurosci. 2006 Feb;9(2):195-204
4641271 - Brain Res. 1972 Nov 27;47(1):262-8
22194569 - Science. 2011 Dec 23;334(6063):1669-75
19680447 - PLoS Genet. 2009 Aug;5(8):e1000604
12198160 - EMBO J. 2002 Sep 2;21(17):4583-92
17334777 - Pflugers Arch. 2007 Jul;454(4):523-33
15541709 - Ageing Res Rev. 2004 Nov;3(4):407-30
16154476 - Cell Calcium. 2005 Sep-Oct;38(3-4):355-67
11108959 - Biochim Biophys Acta. 2000 Dec 20;1498(2-3):162-8
14534243 - J Neurosci. 2003 Oct 8;23(27):9097-106
15356203 - J Neurosci. 2004 Sep 8;24(36):7903-15
21167062 - Mol Pain. 2010;6:95
9106766 - Neuroreport. 1997 Feb 10;8(3):779-82
10078534 - Nature. 1999 Mar 4;398(6722):80-4
21059893 - J Immunol. 2010 Dec 15;185(12):7527-36
14012800 - Nature. 1963 May 11;198:540-2
18817726 - Neuron. 2008 Sep 25;59(6):846-60
11953750 - Nat Neurosci. 2002 May;5(5):405-14
15746104 - J Biol Chem. 2005 May 6;280(18):18008-14
19352544 - Acta Biochim Biophys Sin (Shanghai). 2009 Apr;41(4):295-300
18815592 - Nature. 2008 Oct 30;455(7217):1198-204
21070824 - Biochim Biophys Acta. 2011 May;1813(5):1050-8
20618065 - Antioxid Redox Signal. 2011 Apr 1;14(7):1237-43
15181011 - J Biol Chem. 2004 Aug 6;279(32):33114-22
11792319 - Cell. 2002 Jan 11;108(1):31-43
22822058 - J Biol Chem. 2012 Sep 14;287(38):31674-80
16306395 - J Neurosci. 2005 Nov 23;25(47):10822-30
14960456 - Bioinformatics. 2004 Feb 12;20(3):307-15
B21
B23
B24
B25
B26
B27
Bloodgood BL (B49) 2013; 503
Rivera-Arconada I (B15) 2010; 6
Galanopoulou AS (B39) 2009; 50
Alexander JC (B20) 2009; 16
Mellstrom B (B42) 2004; 16
B30
B31
Palczewska M (B36) 2011; 1813
B32
B34
B35
B37
B38
Rivas M (B47) 2011; 14
B1
B2
B3
B4
B5
B7
B8
B9
Xiong H (B22) 2009; 41
B41
B43
B44
B45
Levi S (B48) 2004; 24
Wang J (B46) 1995; 270
Lilliehook C (B19) 2003; 23
B50
B51
B52
B53
B10
B54
B11
Savignac M (B29) 2010; 185
B12
B13
B14
B16
B17
Savignac M (B18) 2007; 454
Cavazzini M (B6) 2005; 38
Tischmeyer W (B33) 1994; 5
Andersen P (B40) 1963; 198
Takahashi Y (B28) 2000; 14
References_xml – ident: B44
  doi: 10.1126/science.1122511
– ident: B51
  doi: 10.1126/science.1208049
– ident: B10
  doi: 10.1016/S0167-4889(00)00092-6
– volume: 16
  start-page: 167
  year: 2009
  ident: B20
  publication-title: Learn Mem.
  doi: 10.1101/lm.1261709
  contributor:
    fullname: Alexander JC
– ident: B35
  doi: 10.1128/MCB.24.2.608-616.2004
– volume: 38
  start-page: 355
  year: 2005
  ident: B6
  publication-title: Cell Calcium.
  doi: 10.1016/j.ceca.2005.06.013
  contributor:
    fullname: Cavazzini M
– ident: B14
  doi: 10.1016/S0092-8674(01)00629-8
– ident: B52
  doi: 10.1097/00001756-199702100-00040
– ident: B13
  doi: 10.1074/jbc.M105842200
– volume: 454
  start-page: 523
  year: 2007
  ident: B18
  publication-title: Pflugers Arch.
  doi: 10.1007/s00424-007-0238-y
  contributor:
    fullname: Savignac M
– ident: B1
  doi: 10.1038/386855a0
– ident: B32
  doi: 10.1038/nn1627
– volume: 24
  start-page: 207
  year: 2004
  ident: B48
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1661-03.2004
  contributor:
    fullname: Levi S
– ident: B54
  doi: 10.1016/j.arr.2004.07.002
– ident: B31
  doi: 10.1523/JNEUROSCI.0776-04.2004
– ident: B43
  doi: 10.1523/JNEUROSCI.4540-10.2011
– ident: B27
  doi: 10.1016/0896-6273(93)90163-L
– ident: B53
  doi: 10.1038/nrn2738
– ident: B25
  doi: 10.1007/0-387-29362-0_23
– volume: 503
  start-page: 121
  year: 2013
  ident: B49
  publication-title: Nature
  doi: 10.1038/nature12743
  contributor:
    fullname: Bloodgood BL
– ident: B8
  doi: 10.1523/JNEUROSCI.1460-04.2004
– volume: 50
  start-page: 37
  year: 2009
  ident: B39
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2009.02217.x
  contributor:
    fullname: Galanopoulou AS
– ident: B41
  doi: 10.1016/j.neuron.2008.09.002
– ident: B50
  doi: 10.1371/journal.pone.0046604
– volume: 14
  start-page: 1237
  year: 2011
  ident: B47
  publication-title: Antioxid. Redox Signal
  doi: 10.1089/ars.2010.3385
  contributor:
    fullname: Rivas M
– ident: B4
  doi: 10.1152/physrev.00041.2005
– ident: B37
  doi: 10.1126/science.1585183
– ident: B12
  doi: 10.1074/jbc.M500338200
– ident: B3
  doi: 10.1038/31965
– ident: B2
  doi: 10.1038/nn835
– ident: B7
  doi: 10.1038/18044
– ident: B11
  doi: 10.1074/jbc.M403526200
– ident: B21
  doi: 10.1016/S0092-8674(01)00588-8
– ident: B34
  doi: 10.1371/journal.pgen.1000604
– volume: 16
  start-page: 43
  year: 2004
  ident: B42
  publication-title: Crit. Rev. Neurobiol.
  doi: 10.1615/CritRevNeurobiol.v16.i12.40
  contributor:
    fullname: Mellstrom B
– ident: B38
  doi: 10.1038/nature07319
– ident: B9
  doi: 10.1093/emboj/cdf440
– ident: B30
  doi: 10.1016/0006-8993(72)90268-5
– volume: 198
  start-page: 540
  year: 1963
  ident: B40
  publication-title: Nature
  doi: 10.1038/198540a0
  contributor:
    fullname: Andersen P
– volume: 270
  start-page: 30245
  year: 1995
  ident: B46
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.51.30245
  contributor:
    fullname: Wang J
– ident: B26
  doi: 10.2307/2346101
– volume: 23
  start-page: 9097
  year: 2003
  ident: B19
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.23-27-09097.2003
  contributor:
    fullname: Lilliehook C
– volume: 41
  start-page: 295
  year: 2009
  ident: B22
  publication-title: Acta Biochim. Biophys. Sin (Shanghai)
  doi: 10.1093/abbs/gmp013
  contributor:
    fullname: Xiong H
– volume: 1813
  start-page: 1050
  year: 2011
  ident: B36
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2010.11.001
  contributor:
    fullname: Palczewska M
– volume: 6
  start-page: 95
  year: 2010
  ident: B15
  publication-title: Mol. Pain
  doi: 10.1186/1744-8069-6-95
  contributor:
    fullname: Rivera-Arconada I
– ident: B23
  doi: 10.1093/biostatistics/4.2.249
– ident: B5
  doi: 10.1074/jbc.R112.384982
– volume: 5
  start-page: 1501
  year: 1994
  ident: B33
  publication-title: Neuroreport
  doi: 10.1097/00001756-199407000-00023
  contributor:
    fullname: Tischmeyer W
– volume: 14
  start-page: 804
  year: 2000
  ident: B28
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.7.804
  contributor:
    fullname: Takahashi Y
– volume: 185
  start-page: 7527
  year: 2010
  ident: B29
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1000152
  contributor:
    fullname: Savignac M
– ident: B17
  doi: 10.1523/JNEUROSCI.3912-05.2005
– ident: B45
  doi: 10.1186/1756-6606-3-3
– ident: B16
  doi: 10.1038/sj.emboj.7600810
– ident: B24
  doi: 10.1093/bioinformatics/btg405
SSID ssj0006903
Score 2.3037658
Snippet OA  Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
Changes in nuclear Ca 2+ homeostasis activate specific gene expression programs and are central to the acquisition and storage of information in the brain....
Changes in nuclear Ca(2+) homeostasis activate specific gene expression programs and are central to the acquisition and storage of information in the brain....
SourceID pubmedcentral
csuc
proquest
crossref
pubmed
informaworld
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 877
SubjectTerms Animals
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
Calcium - metabolism
Cells, Cultured
Cervell
Cyclic AMP Response Element-Binding Protein - genetics
Cyclic AMP Response Element-Binding Protein - metabolism
Dentate Gyrus - metabolism
Down-Regulation - genetics
GABAergic Neurons - metabolism
Genètica
Hippocampus - metabolism
Kv Channel-Interacting Proteins - genetics
Kv Channel-Interacting Proteins - metabolism
Learning
Mice
Mice, Transgenic
Promoter Regions, Genetic - genetics
Prosencephalon - metabolism
Proteïnes
Repressor Proteins - genetics
Repressor Proteins - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic - genetics
SummonAdditionalLinks – databaseName: Taylor & Francis_OA刊
  dbid: 0YH
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwELWqRQguCMpXKCAjwQUp1LGdxDku21YrpKUIKCona-za6h6aRU1WVf99Z5LNanfVC4dIifKd54zfOJP3GPsotPeFK10aKlmkWsUsdVACfX3E5MOYCrpq99n3Ynqmv53n53vMDP_CUFkl5dCxF4roYjW93OBWDiTSHM4mX7-QjopIya72gUTGTS1c_J2uYzDmfGooc9_ZY6sDGvlm6Te0gXcES--jnbvVkxvd0clT9mTFI_m4B_4Z2wv1PnvYO0ve7rNHk8HI7Tn7c_TzeDzjk74oveFI-fhpfXgaI_91M0fU-ALnyIc-zj0f-95PIj1a2eO2vOvPhujCfyBnvIHb5gU7Ozn-PZmmKzuF1BfCtOmFNznEDGQBWQDMJALpXeWBJOJlUTkkP0bngC9kEBqQ-IjCQF4pCNL5iDTpJRvVizq8ZpyMrJwWymsoEWzlsgw8gIkXJbi8rBL2aXjG9l-vmmG7bEMai1jYDgubqYR9JgAsBvdw7aG1JHa9XqBJilJaldHYdcKSASYLzZW98s4qbXNryjJhYhM323bDHbH3JsH97z33hwFbi4DQdxKow2LZYDaEpFljdMPDvuqxXt-F1Ir8mvOElVutYL0B3cH2mnp-2cl2a6JHKnvz_5d6wB4jT9N96dtbNmqvl-EdcqHWve-a_R22FAW9
  priority: 102
  providerName: Taylor & Francis
Title DREAM Controls the On/Off Switch of Specific Activity-Dependent Transcription Pathways
URI http://mcb.asm.org/content/34/5/877.abstract
https://www.tandfonline.com/doi/abs/10.1128/MCB.00360-13
https://www.ncbi.nlm.nih.gov/pubmed/24366545
https://search.proquest.com/docview/1499140407
https://recercat.cat/handle/2072/315230
https://pubmed.ncbi.nlm.nih.gov/PMC4023831
Volume 34
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBZNYGwvY-su9S5Fg-1l4NiWZEt-zNyWsJG1u3R0T0JSZRZYnFI7lP77HclWSEqf9mBjY8tG_o6k70jH50PofcqMKTTXsS1JETNaZ7FWXLnVR3A-hCiVj3affy1m5-zzRX6xh_LwL4wP2jd6MWn-LifN4o-PrbxamiTEiSVn84q5gYZmyQiNOKXBRR-6X3D3_LIy4WkM5luEaHciknn1aeISsKRx5vRzCKNOezffGZLGpl2brWzBd1KY3kdE78ZTbg1QJ0_Q44FZ4mlfg6dozzb76EGvNXm7jx5WQdrtGfp19P14OsdVH6beYiCB-LRJTusa_7hZAI54BUdOmb5eGDw1vcJEfDQI5nbYj3Chv8FnwCJv1G37HJ2fHP-sZvEgsBCbIhVdfGlErupMkUJlVoFvYV0GrNy6pPGkKDXQIcFyBU3UpkwBFUoLofKSKku0qYE4vUDjZtXYA4SdtJVmKTVMcYCf6ixTRilRX3Klc15G6EP4xvKqz6Mhvf9BhARYpIdFZjRCHx0AErp7e21UJ136682J20jKiaSZm82OUBRgkqpdyqXRkjKZS8F5hNJt3GTnJ0DqXq0Eyt_77ncBWwmAuJUT1djVugX_CGg0g_4OHvuyx3pTi2BFEeI7VrC5wdVg9wrYtU_kPdjxq_8u-Ro9AgLH-pi4N2jcXa_tWyBJnT5Eo_T3DPZfvolD30D-AfznEFg
link.rule.ids 230,315,733,786,790,891,27533,27955,27956,53825,53827,59496,59497
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwELXQIlQuiJav8NEaCS5IoU5sJ85x2bZaoNsiaFE5WWPXEXtoFjVZVf33zCSb1e6qlx4iJcp3Xjx-Y4_eY-yDUN5nLndxKNIsVrJMYgc50OwjJh_GFNBWu09OsvG5-nahL1asvqisknLoshOKaGM1NW4ajF54Epr9yejLZxJSETH51T7UhSoo7xJ_xssgjEmf7OvcN85Y64EGvp77FXHgDcXSu3jnZvnkSn909JQ9WRBJPuyQ32YPQrXDHnXWkrc7bGvUO7k9Y78Pfh4OJ3zUVaXXHDkfP632T8uS_7qZImx8hmtkRF9OPR_6zlAiPlj44za87dD68MJ_IGm8gdv6OTs_OjwbjeOFn0LsM2Ga-NIbDWUCaQZJAEwlAgle6UAa8WlWOGQ_RmnAFhmEAmQ-IjOgCwkhdb5EnvSCDapZFV4xTk5WTgnpFeSItnRJAh7AlJc5OJ0XEfvYf2P7r5PNsG26kRqLWNgWC5vIiH0iACxG93DtobGkdr3coCUVeWplQoPXEYt6mCzUV_bKOyuV1dbkecTEKm62acc7ys6cBM-_897ve2wtAkITJVCF2bzGdAhZs8Lwhpd92WG9fItUSTJs1hHL1_6C5QH0But7qunfVrdbET-Syev7P-oe2xqfTY7t8deT72_YYyRtqquDe8sGzfU8vENi1Ljdtgn8B-5JCTM
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb5tAEB5Frvq4VGn6om3SrdReKtEAu8BydOxY7sNJ1DZVclrNrndVH4KjgBXl33cWjGVbufSABOLNx85-swzfB_AxEsZkOtehLZIsFNzFocYc_ddHSj6kLLCpdp-cZONz8e0ivdgB2f0L48sqfQ7tWqGIJlb7xn09dUtLQnk4GRx98ToqUejtah-khSj8ux1djlcxmHI-3pW5b-2x0QH1TLUwa9rAW4Kl99HO7erJte5otAtPlzyS9Vvgn8GOLffgYessebcHjwedkdtz-DP8edyfsEFblF4xonzstDw8dY79up0RamxOc96H3s0M65vWTyIcLu1xa9b0Z110YWfEGW_xrnoB56Pj34NxuLRTCE0WyTqcGpmiizHJMLZImYT1elep9RLxSVZoIj9SpEgN0kYCifhEmcS04GgTbRzRpJfQK-elfQ3MG1lpEXEjMCewuY5jNIjSTXPUaV4E8Kl7xuq6Vc1QTbaRSEVYqAYLFfMAPnsAFAV3e2OwVl7serXgpyTKE8VjP3YdQNDBpLC6UldGKy5UqmSeBxCt46bqZrjDtd4ktP-95_7QYasIEP-dBEs7X1SUDRFpFhTd6LCvWqxXd5EI7v2a0wDyjbdgtYG_g8015exvI9stPD3i8Zv_v9T38OhsOFI_vp58fwtPiLKJtgruHfTqm4XdJ1pU64OmBfwDQqIIXA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=DREAM+Controls+the+On%2FOff+Switch+of+Specific+Activity-Dependent+Transcription+Pathways&rft.jtitle=Molecular+and+cellular+biology&rft.au=Mellstr%C3%B6m%2C+Britt&rft.au=Sah%C3%BAn%2C+Ignasi&rft.au=Ruiz-Nu%C3%B1o%2C+Ana&rft.au=Murtra%2C+Patricia&rft.date=2014-03-01&rft.issn=1098-5549&rft.eissn=1098-5549&rft.volume=34&rft.issue=5&rft.spage=877&rft.epage=887&rft_id=info:doi/10.1128%2FMCB.00360-13&rft.externalDBID=n%2Fa&rft.externalDocID=10_1128_MCB_00360_13
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-7306&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-7306&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-7306&client=summon