Disease progression model for Clinical Dementia Rating-Sum of Boxes in mild cognitive impairment and Alzheimer's subjects from the Alzheimer's Disease Neuroimaging Initiative

• Published in: Neuropsychiatric disease and treatment Vol. 10; no. default; pp. 929 - 952
• Main Authors: Samtani, Mahesh, Raghavan, Nandini, Novak, Gerald, Nandy, Partha, Narayan, Vaibhav A
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2014; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Alzheimer's disease; beta-regression; Biomarkers; Cerebrospinal fluid; Clinical trials; Cognitive ability; CSF Aß1-42; Dementia; Dementia disorders; Development and progression; Diagnostic imaging; hippocampal volume; Hippocampus; Hypotheses; Image processing; Neurodegenerative diseases; Neuroimaging; NMR; NONMEM; Nuclear magnetic resonance; Original Research; Population; Population studies; R&D; Research & development; Survival analysis; trial enrichment; New York; United States > US; trial enrichment; CSF Aβ1–42; hippocampal volume; beta-regression; NONMEM

The objective of this analysis was to develop a nonlinear disease progression model, using an expanded set of covariates that captures the longitudinal Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) scores. These were derived from the Alzheimer's Disease Neuroimaging Initiative ADNI-1 stu...