Brequinar inhibits African swine fever virus replication in vitro by activating ferroptosis

• Published in: Virology journal Vol. 20; no. 1; p. 242
• Main Authors: Chen, Yang, Guo, Yanchen, Chang, Hao, Song, Zebu, Wei, Zhi, Huang, Zhao, Zheng, Zezhong, Zhang, Guihong, Sun, Yankuo
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 24.10.2023; BioMed Central; BMC
• Subjects: African swine fever; African swine fever virus; agonists; Alveoli; Antiviral activity; Antiviral agents; Antiviral drugs; antiviral properties; Asfarviridae; biochemical pathways; Biosynthesis; Brequinar; Care and treatment; Cisplatin; Classical swine fever virus; Confocal microscopy; Cytotoxicity; Dehydrogenases; Dengue fever; Diagnosis; dose response; Drug development; Drugs; economic impact; Enzymes; etiology; Ferroptosis; Hog cholera; Hogs; Infections; Intracellular; iron; Laboratories; lipids; Macrophages; mitochondria; Monoclonal antibodies; Pork; Pork industry; Pyrimidines; Replication; Risk factors; Swine; Uridine; Vaccines; virus replication; Viruses; Western blotting; China; Africa; United States > US; Europe; Japan; Germany

African swine fever virus (ASFV) is one of the most fatal swine etiological agents and has a huge economic impact on the global pork industry. Given that no effective vaccines or anti-ASFV drugs are available, there remains a pressing need for novel anti-ASFV drugs. This study aimed to investigate t...