Genomic epidemiology of methicillin-resistant and -susceptible Staphylococcus aureus from bloodstream infections

• Published in: BMC infectious diseases Vol. 21; no. 1; pp. 1 - 14
• Main Authors: Smith, Joshua T., Eckhardt, Elissa M., Hansel, Nicole B., Eliato, Tahmineh Rahmani, Martin, Isabella W., Andam, Cheryl P.
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 21.06.2021; BioMed Central; BMC
• Subjects: Aminoglycosides; Antibiotics; Antimicrobial agents; Antimicrobial resistance; Bacteria; Blood culture; Bloodstream infection; Case studies; Cloning; Codominance; Drug resistance; Epidemiology; Genes; Genetic aspects; Genetic testing; Genome evolution; Genomes; Health care facilities; Human subjects; Infectious diseases; Intervals; Medical laboratories; Methicillin; Methicillin resistance; Morbidity; Mortality; Multidrug resistance; Patients; Penicillin; Population; Population growth; Population number; Recombination; Robust control; Staphylococcus aureus; Staphylococcus infections; Virulence; β-Lactam antibiotics; United States; United States > US; New Hampshire

Bloodstream infections due to Staphylococcus aureus cause significant patient morbidity and mortality worldwide. Of major concern is the emergence and spread of methicillin-resistant S. aureus (MRSA) in bloodstream infections, which are associated with therapeutic failure and increased mortality. We...