Discrimination of primary and chronic cytomegalovirus infection based on humoral immune profiles in pregnancy

• Published in: The Journal of clinical investigation Vol. 134; no. 20; pp. 1 - 12
• Main Authors: Hederman, Andrew P., Remmel, Christopher A.L., Sharma, Shilpee, Natarajan, Harini, Weiner, Joshua A., Wrapp, Daniel, Donner, Catherine, Delforge, Marie-Luce, d’Angelo, Piera, Furione, Milena, Fornara, Chiara, McLellan, Jason S., Lilleri, Daniele, Marchant, Arnaud, Ackerman, Margaret E.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 15.10.2024
• Subjects: Adult; Antibodies; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody response; Antigens; Asymptomatic; B cells; Chronic Disease; Chronic infection; Clinical Medicine; Congenital diseases; Cytomegalovirus; Cytomegalovirus - immunology; Cytomegalovirus infections; Cytomegalovirus Infections - immunology; Discrimination; Disease susceptibility; Female; Fetuses; Gestational age; Glycoprotein B; Glycoproteins; Health aspects; Humans; Humoral immunity; Identification and classification; Immune response; Immune system; Immunity (Disease); Immunity, Humoral - immunology; Immunoglobulin A; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunoglobulin M; Immunoglobulin M - blood; Immunoglobulin M - immunology; Infection; Infections; Machine learning; Medical research; Medicine, Experimental; Observational learning; Opportunist infection; Physiological aspects; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - virology; Serology; Tegument; Viral infections; Virus diseases; Womens health; Belgium; United States; United States > US; Antigen; Infectious disease; Immunoglobulins; Adaptive immunity; Immunology

BACKGROUNDMost humans have been infected with cytomegalovirus (CMV) by midlife without clinical signs of disease. However, in settings in which the immune system is undeveloped or compromised, the virus is not adequately controlled and consequently presents a major infectious cause of both congenita...