Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson's disease

• Published in: Neurobiology of disease Vol. 31; no. 3; pp. 406 - 412
• Main Authors: Ardayfio, Paul, Moon, JiSook, Leung, Ka Ka Amanda, Youn-Hwang, Dong, Kim, Kwang-Soo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2008; Elsevier
• Subjects: Animals; Aphakia - genetics; Aphakia - metabolism; Aphakia - physiopathology; Avoidance Learning - physiology; Cognition; Cognition Disorders - genetics; Cognition Disorders - physiopathology; Corpus Striatum - physiopathology; Disease Models, Animal; Dopamine; Dopamine - metabolism; Feeding Behavior - physiology; Genetic Predisposition to Disease - genetics; Homeodomain Proteins - genetics; Learning Disabilities - genetics; Learning Disabilities - metabolism; Learning Disabilities - physiopathology; Male; Maze Learning - physiology; Memory Disorders - genetics; Memory Disorders - metabolism; Memory Disorders - physiopathology; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Neurology; Parkinson Disease - complications; Parkinson Disease - physiopathology; Parkinson's disease; Pitx3; Social Behavior; Striatum; Transcription Factors - deficiency; Transcription Factors - genetics; Striatum; Cognition; Parkinson's disease; Dopamine; Pitx3

Disorders of the basal ganglia such as Parkinson's disease (PD) and Huntington's disease are commonly thought of primarily as motor disorders; however, the cognitive symptoms of these diseases such as executive dysfunction, learning, memory and attention deficits are prominent and often mo...