Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1–Stimulated Postprandial Insulin Secretion in Humans

• Published in: Diabetes (New York, N.Y.) Vol. 60; no. 9; pp. 2308 - 2314
• Main Authors: Salehi, Marzieh, Prigeon, Ronald L., D’Alessio, David A.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.09.2011
• Subjects: Adult; Asymptomatic; Biological and medical sciences; Blood Glucose; Carbohydrates; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Gastric Bypass; Gastrointestinal surgery; Glucagon; Glucagon - blood; Glucagon-Like Peptide 1 - blood; Glucagon-Like Peptide 1 - pharmacology; Glucose; Health aspects; Humans; Hypoglycemia; Hypotheses; Insulin; Insulin - blood; Insulin - metabolism; Insulin Secretion; Islet Studies; Male; Medical sciences; Metabolic diseases; Middle Aged; Pancreas - drug effects; Pancreas - metabolism; Peptide hormones; Peptides; Physiological aspects; Plasma; Postprandial Period - physiology; Research design; Risk factors; United States; Endocrinopathy; Human; Stomach; Pancreatic hormone; Digestive system; Postprandial; Secretion; Diabetes mellitus; Insulin; Glucagon like peptide 1; Gastrointestinal hormone; Bypass; Surgery

Gastric bypass (GB) surgery is associated with postprandial hyperinsulinemia, and this effect is accentuated in postsurgical patients who develop recurrent hypoglycemia. Plasma levels of the incretin glucagon-like peptide 1 (GLP-1) are dramatically increased after GB, suggesting that its action cont...