Netrin-3, a Mouse Homolog of Human NTN2L, Is Highly Expressed in Sensory Ganglia and Shows Differential Binding to Netrin Receptors

• Published in: The Journal of neuroscience Vol. 19; no. 12; pp. 4938 - 4947
• Main Authors: Wang, Hao, Copeland, Neal G, Gilbert, Debra J, Jenkins, Nancy A, Tessier-Lavigne, Marc
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 15.06.1999; Society for Neuroscience
• Subjects: Animals; Axons - chemistry; Axons - physiology; Blotting, Northern; Cells, Cultured; Chick Embryo; Chromosome Mapping; Cloning, Molecular; DNA Primers; Female; Ganglia, Sensory - chemistry; Ganglia, Sensory - cytology; Ganglia, Sensory - embryology; Gene Expression Regulation, Developmental; Humans; Male; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Motor Neurons - chemistry; Motor Neurons - physiology; Motor Neurons - ultrastructure; Nerve Growth Factors - metabolism; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Netrin Receptors; Netrin-1; Netrins; Peripheral Nervous System - chemistry; Peripheral Nervous System - cytology; Peripheral Nervous System - embryology; Radioligand Assay; Receptors, Cell Surface - metabolism; Recombinant Fusion Proteins - metabolism; RNA, Messenger - analysis; Sequence Homology, Amino Acid; Spinal Cord - chemistry; Spinal Cord - cytology; Transfection; Tumor Suppressor Proteins

The netrins comprise a small phylogenetically conserved family of guidance cues important for guiding particular axonal growth cones to their targets. Two netrin genes, netrin-1 and netrin-2, have been described in chicken, but in mouse so far a single netrin gene, an ortholog of chick netrin-1, has...