Arsenic, internal cancers, and issues in inference from studies of low-level exposures in human populations

• Published in: Toxicology and applied pharmacology Vol. 222; no. 3; pp. 252 - 257
• Main Authors: Cantor, Kenneth P., Lubin, Jay H.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: San Diego, CA Elsevier Inc 01.08.2007; Elsevier
• Subjects: 60 APPLIED LIFE SCIENCES; Animals; ARSENIC; Arsenic - toxicity; Biological and medical sciences; BLADDER; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - toxicity; Chemical agents; Chemical and industrial products toxicology. Toxic occupational diseases; DRINKING WATER; Environmental Exposure; EPIDEMIOLOGY; Exposure misclassification; EXTRAPOLATION; HEALTH HAZARDS; Human risk; Humans; Medical sciences; Metals and various inorganic compounds; NEOPLASMS; Neoplasms - chemically induced; Neoplasms - epidemiology; Risk Assessment; Toxicology; Tumors; Urinary Bladder Neoplasms - chemically induced; Urinary Bladder Neoplasms - epidemiology; Water Supply - analysis; USA; Drinking water; Human risk; Arsenic; Epidemiology; Exposure misclassification; Human; Carcinogen; Risk factor; Risk; Exposure; Malignant tumor; Cancer

Epidemiologic data from regions of the world with very high levels of arsenic in drinking water (> 150 μg/L) show a strong association between arsenic exposure and risk of several internal cancers. A causal interpretation of the data is warranted based on the strength and consistency of study fin...