Developmental toxicity of low generation PAMAM dendrimers in zebrafish

• Published in: Toxicology and applied pharmacology Vol. 225; no. 1; pp. 70 - 79
• Main Authors: King Heiden, Tisha C., Dengler, Emelyne, Kao, Weiyuan John, Heideman, Warren, Peterson, Richard E.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.11.2007; Elsevier
• Subjects: 60 APPLIED LIFE SCIENCES; Animals; Biological and medical sciences; CARBOXYLIC ACIDS; CELL CULTURES; Danio rerio; Dendrimer; Dendrimers; Developmental toxicity; Dose-Response Relationship, Drug; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Carriers - toxicity; Drug Delivery Systems; DRUGS; Embryology: invertebrates and vertebrates. Teratology; Embryonic Development - drug effects; EMBRYOS; Fundamental and applied biological sciences. Psychology; GENE THERAPY; Integrins - metabolism; LIGANDS; Medical sciences; Models, Animal; NANOSTRUCTURES; Nanotherapeutics; Nanotoxicology; Oligopeptides - administration & dosage; Oligopeptides - toxicity; Polyamines - administration & dosage; Polyamines - chemistry; Polyamines - toxicity; PUBLIC HEALTH; RECEPTORS; RGD; Structure-Activity Relationship; Teratology. Teratogens; Time Factors; TOXICITY; Toxicity Tests; Toxicology; Zebrafish; Zebrafish embryo; Nanotherapeutics; Dendrimer; Developmental toxicity; Nanotoxicology; G; PAMAM; RGD; Zebrafish embryo; Teratogenesis; Vertebrata; Brachydanio rerio; Embryo; Toxicity; Pisces

Biological molecules and intracellular structures operate at the nanoscale; therefore, development of nanomedicines shows great promise for the treatment of disease by using targeted drug delivery and gene therapies. PAMAM dendrimers, which are highly branched polymers with low polydispersity and hi...