Fucoidan Stimulates Monocyte Migration via ERK/p38 Signaling Pathways and MMP9 Secretion

• Published in: Marine drugs Vol. 13; no. 7; pp. 4156 - 4170
• Main Authors: Sapharikas, Elene, Lokajczyk, Anna, Fischer, Anne-Marie, Boisson-Vidal, Catherine
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.06.2015; MDPI
• Subjects: Adhesion; Biological effects; Blotting, Western; Cell Adhesion - drug effects; Cell Movement - drug effects; Cellular Biology; critical limb ischemia; Dose-Response Relationship, Drug; Flow Cytometry; fucoidan; Humans; Integrins - physiology; Life Sciences; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - physiology; Matrix Metalloproteinase 9 - physiology; Matrix Metalloproteinase 9 - secretion; migration; monocytes; Monocytes - drug effects; Monocytes - physiology; Polysaccharides - pharmacology; Receptors, CCR2 - physiology; migration; monocytes; critical limb ischemia; fucoidan

Critical limb ischemia (CLI) induces the secretion of paracrine signals, leading to monocyte recruitment and thereby contributing to the initiation of angiogenesis and tissue healing. We have previously demonstrated that fucoidan, an antithrombotic polysaccharide, promotes the formation of new blood...