Contributions of the Raf MEK ERK, PI3K PTEN Akt mTOR and Jak STAT pathways to leukemia

• Published in: Leukemia Vol. 22; no. 4; pp. 686 - 707
• Main Authors: Steelman, L S, Abrams, S L, Whelan, J, Bertrand, F E, Ludwig, D E, Bäsecke, J, Libra, M, Stivala, F, Milella, M, Tafuri, A, Lunghi, P, Bonati, A, Martelli, A M, McCubrey, J A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2008; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Cancer Research; Cellular signal transduction; Chromosome 10; Chromosome translocations; Critical Care Medicine; Extracellular signal-regulated kinase; Gene mutations; Genetic aspects; Growth factor receptors; Growth factors; Health aspects; Hematology; Homology; Humans; Intensive; Internal Medicine; Kinases; Leukemia; Leukemia - etiology; Medicine; Medicine & Public Health; Mutation; Neoplasia; Neoplasms; Oncology; Phosphatase; Phosphatidylinositol 3-Kinases - metabolism; Protein Kinases - metabolism; PTEN Phosphohydrolase - metabolism; PTEN protein; Raf protein; review; Risk factors; Signal Transduction; STAT Transcription Factors - metabolism; Survival; Tensin; TOR protein; United States; inhibitors; Akt; PI3K; signal transduction; chemotherapeutic drugs; Raf

Mutations and chromosomal translocations occur in leukemic cells that result in elevated expression or constitutive activation of various growth factor receptors and downstream kinases. The Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways are often activated by mutations in upstream genes. The...