The role of the complement system in cancer

• Published in: The Journal of clinical investigation Vol. 127; no. 3; pp. 780 - 789
• Main Author: Afshar-Kharghan, Vahid
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.03.2017
• Subjects: Animals; Antigens; Apoptosis - immunology; Biomedical research; Cancer; Cell Communication - immunology; Cell Proliferation; Chemotherapy; Clinical trials; Complement Pathway, Alternative - immunology; Complement Pathway, Classical - immunology; Complement system; Complement System Proteins - immunology; Complications and side effects; Dendritic cells; Development and progression; Humans; Immunoglobulins; Inflammation; Ligands; Lymphocytes; Neoplasms - immunology; Neutrophils; Proteins; Regulation; Review; Signal transduction; Signal Transduction - immunology; United States

In addition to being a component of innate immunity and an ancient defense mechanism against invading pathogens, complement activation also participates in the adaptive immune response, inflammation, hemostasis, embryogenesis, and organ repair and development. Activation of the complement system via...