Analysis of Disease Activity Metrics in a Methotrexate Withdrawal Study among Patients with Rheumatoid Arthritis Treated with Tofacitinib plus Methotrexate

• Published in: Rheumatology and therapy. Vol. 10; no. 2; pp. 375 - 386
• Main Authors: Fleischmann, Roy, Haraoui, Boulos, Buch, Maya H., Gold, David, Sawyerr, Gosford, Shi, Harry, Diehl, Annette, Lee, Kristen
• Format: Journal Article
• Language: English
• Published: Cheshire Springer Healthcare 01.04.2023; Springer Nature B.V; Adis, Springer Healthcare
• Subjects: Disease control; Family Medicine; General Practice; Immunomodulators; Inflammation; Internal Medicine; Kinases; Medicine; Medicine & Public Health; Methotrexate; NCT; NCT02831855; Original Research; Orthopedics; Patients; Proteins; Quality of Life Research; Remission (Medicine); Response rates; Rheumatoid arthritis; Rheumatology; Therapeutics; Inflammation; Methotrexate; Rheumatoid arthritis; Therapeutics

Introduction The objective of this analysis was to assess disease activity metrics using a variety of disease outcome measures following methotrexate (MTX) withdrawal in ORAL Shift, a phase 3b/4 study of tofacitinib with/without MTX, in patients with rheumatoid arthritis (RA) achieving Clinical Dise...