A cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)

• Published in: BMC infectious diseases Vol. 21; no. 1; pp. 1 - 814
• Main Authors: Iturriaga, Carolina, Eiffler, Nat, Aniba, Rad, Ben-Othman, Rym, Perez-Mateluna, Guillermo, Meyer, Jessica K. V, Fish, Eleanor N, Kollmann, Tobias R, Severino, Nicolas, Stick, Stephen, Borzutzky, Arturo, Perret, Cecilia, Castro-Rodriguez, José A, Garcia-Huidobro, Diego
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 13.08.2021; BioMed Central; BMC
• Subjects: Biological response modifiers; Clusters; Consent; Control; Coronavirus; Coronaviruses; COVID; COVID-19; COVID-19 vaccines; Disease prevention; Disease transmission; Exposure; Health care networks; Households; Infections; Influenza; Interferon; Interferon alpha; Pandemics; Primary care; Protocol; Randomization; Respiratory diseases; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Shedding; Study Protocol; Testing; Transmission; Viral diseases; Viral infections; Chile; China

SARS-CoV-2 infection rapidly spreads in populations due to the high rates of community transmission. Interrupting the shedding of SARS-CoV-2 may reduce the incidence of Coronavirus Disease 19 (COVID-19). Herein we provide a protocol for a cluster randomized trial that will examine the effectiveness...