Inhibition of FOSL2 aggravates the apoptosis of ovarian cancer cells by promoting the formation of inflammasomes

• Published in: Genes & genomics Vol. 44; no. 1; pp. 29 - 38
• Main Authors: Li, Jie, Zhou, Li, Jiang, Hongye, Lin, Lin, Li, Yinguang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.01.2022; Springer; Springer Nature B.V; 한국유전학회
• Subjects: Amino Acid Chloromethyl Ketones - pharmacology; Animal Genetics and Genomics; Antigens; Apoptosis; Apoptosis - genetics; Aspartate; Biomedical and Life Sciences; carcinogenesis; Caspase 1 - genetics; Caspase 1 - metabolism; Caspase-1; Cell Movement - drug effects; Cell Movement - genetics; Cell proliferation; Cell Proliferation - drug effects; Cell Proliferation - genetics; Cell Survival - drug effects; Cell Survival - genetics; Cysteine; Cysteine Proteinase Inhibitors - pharmacology; Cytokines; Development and progression; Enzyme-linked immunosorbent assay; Enzymes; Female; females; fluorescence; Fos-Related Antigen-2 - genetics; Fos-Related Antigen-2 - metabolism; Gene Expression Regulation, Neoplastic; genomics; Health aspects; Human Genetics; Humans; IL-1β; Inflammasomes; Inflammasomes - drug effects; Inflammasomes - genetics; Inflammasomes - metabolism; Interleukin 18; Interleukin-18 - genetics; Interleukin-18 - metabolism; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; Interleukins; L-Lactate dehydrogenase; lactate dehydrogenase; Lactic acid; Life Sciences; Malignancy; Microbial Genetics and Genomics; Ovarian cancer; Ovarian carcinoma; ovarian neoplasms; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Plant Genetics and Genomics; Plasmids; Proteinase; quantitative polymerase chain reaction; Research Article; RNA Interference; Transfection; Up-Regulation - drug effects; Western blotting; Women; 생물학; Yvad-CMK; Inflammasome; FOSL2; Ovarian cancer

Background Ovarian cancer is a common gynecological malignancy among female patients and poses a serious threat to women’s health. Although it has been established that Fos-like antigen 2 (FOSL2) is linked to ovarian cancer (OC), its exact role in the development of OC remains unknown. Objective Thi...