Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 39; no. 9; pp. 2061 - 2069
• Main Authors: Dodhia, Sonam, Hosanagar, Avinash, Fitzgerald, Daniel A, Labuschagne, Izelle, Wood, Amanda G, Nathan, Pradeep J, Phan, K Luan
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.08.2014
• Subjects: Administration, Intranasal; Adult; Adult and adolescent clinical studies; Amygdala - drug effects; Amygdala - physiopathology; Anxiety; Anxiety Disorders - drug therapy; Anxiety Disorders - physiopathology; Anxiety disorders. Neuroses; Biological and medical sciences; Central Nervous System Agents - administration & dosage; Cross-Over Studies; Double-Blind Method; Frontal Lobe - drug effects; Frontal Lobe - physiopathology; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Miscellaneous; Neural Pathways - drug effects; Neural Pathways - physiopathology; Original; Oxytocin - administration & dosage; Phobia; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rest; Social Perception; Young Adult; Human; Functional connectivity; Amygdala; Pathophysiology; Social phobia; Central nervous system; Anxiety disorder; Basal ganglion; Oxytocic; Encephalon; Generalized anxiety disorder; Neurohypophyseal hormone; Oxytocin(drug); Amygdaloid nucleus

Generalized social anxiety disorder (GSAD) is characterized by aberrant patterns of amygdala-frontal connectivity to social signals of threat and at rest. The neuropeptide oxytocin (OXT) modulates anxiety, stress, and social behaviors. Recent functional neuroimaging studies suggest that these effect...