Mutation of the MYH3 gene causes recessive cleft palate in Limousine cattle

• Published in: Genetics selection evolution (Paris) Vol. 54; no. 1; p. 71
• Main Authors: Vaiman, Anne, Fritz, Sébastien, Beauvallet, Christian, Boussaha, Mekki, Grohs, Cécile, Daniel-Carlier, Nathalie, Relun, Anne, Boichard, Didier, Vilotte, Jean-Luc, Duchesne, Amandine
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 29.10.2022; BioMed Central; BMC
• Subjects: Abnormalities; Analysis; Animals; Beef cattle; Biotechnology industry; Birth defects; Bos taurus; Cattle; Cattle / genetics; Cleft lip/palate; Cleft palate; Cleft Palate / genetics; Cleft Palate / veterinary; Congenital diseases; Embryogenesis; Embryonic growth stage; Frameshift Mutation; Gene deletion; Gene frequency; Gene mapping; Genes; Genetic aspects; Genomes; Genomics; Genotyping; Haplotypes; Heredity; Homozygosity; Life expectancy; Life Sciences; Life span; Male; Mammals / genetics; mRNA turnover; Muscle proteins; Muscles; Mutation; Myosin; Nonsense mutation; Pedigree; Proteins; RNA; Single-nucleotide polymorphism; Software; France; United States

The palate is a structure separating the oral and nasal cavities and its integrity is essential for feeding and breathing. The total or partial opening of the palate is called a cleft palate and is a common malformation in mammals with environmental or hereditary aetiologies. Generally, it compromis...