The emerging and diverse roles of F-box proteins in spermatogenesis and male infertility

• Published in: Cell regeneration Vol. 13; no. 1; pp. 13 - 12
• Main Authors: Zhuang, Xuan, Ruan, Jun, Zhou, Canquan, Li, Zhiming
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 26.06.2024; Springer Nature B.V; SpringerOpen
• Subjects: Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell division; CRISPR; Cullin; Enzymes; F-box protein; F-box proteins; Fertility; Germ cells; Infertility; Life Sciences; Male germ cells; Male infertility; Mutation; Phosphorylation; Physiology; Proteins; Proteolysis; Review; Sperm; Spermatogenesis; Stem Cells; T cell receptors; Ubiquitin-protein ligase; Ubiquitylation; F-box proteins; Spermatogenesis; Ubiquitylation; Male infertility; Male germ cells

F-box proteins play essential roles in various cellular processes of spermatogenesis by means of ubiquitylation and subsequent target protein degradation. They are the substrate-recognition subunits of SKP1–cullin 1–F-box protein (SCF) E3 ligase complexes. Dysregulation of F‑box protein‑mediated pro...