Pharmacodynamic Analysis of Recombinant Human Erythropoietin Effect on Reticulocyte Production Rate and Age Distribution in Healthy Subjects

• Published in: Clinical pharmacokinetics Vol. 47; no. 6; pp. 399 - 415
• Main Authors: Pérez-Ruixo, Juan José, Krzyzanski, Wojciech, Hing, Jeremy
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2008; Adis international; Wolters Kluwer Health, Inc; Springer Nature B.V
• Subjects: Adolescent; Adult; Age Distribution; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Clinical Trials as Topic; Erythropoietin - pharmacokinetics; Erythropoietin - pharmacology; Hematinics - pharmacokinetics; Hematinics - pharmacology; Humans; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Models, Biological; Original Research Article; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Randomized Controlled Trials as Topic; Recombinant Proteins; Reticulocyte Count; Reticulocytes - cytology; Reticulocytes - drug effects; Mean Residence Time; Maturation Time; Residence Time Distribution; Reticulocyte Count; Pharmacodynamic Model; Human; Pharmacodynamics; Erythropoietin; Healthy subject; Polypeptide; Subcutaneous administration; Biosynthesis; Models; Reticulocyte; Recombinant protein; Biological activity; Age distribution

Objective: To evaluate the effect of recombinant human erythropoietin (rHuEPO) on the reticulocyte production rate and age distribution in healthy subjects. Methods: Extensive pharmacokinetic and pharmacodynamic data collected from 88 subjects who received a single subcutaneous dose of rHuEPO (dose...