Neuronal cell death in neonatal hypoxia-ischemia

• Published in: Annals of neurology Vol. 69; no. 5; pp. 743 - 758
• Main Authors: Northington, Frances J., Chavez-Valdez, Raul, Martin, Lee J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2011; Wiley-Liss; Wiley Subscription Services, Inc
• Subjects: Animals; Apoptosis; Autophagy; Biological and medical sciences; Caspases - metabolism; Cell Death - physiology; Humans; Hypoxia-Ischemia, Brain - metabolism; Hypoxia-Ischemia, Brain - pathology; Hypoxia-Ischemia, Brain - physiopathology; Infant; Medical research; Medical sciences; Membrane Proteins - metabolism; Models, Biological; Necrosis; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurodegenerative Diseases - physiopathology; Neurology; Neurons - physiology; Pediatrics; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Signal Transduction - physiology; Vascular diseases and vascular malformations of the nervous system; Human; Oxygen; Neonatal; Nervous system diseases; Newborn; Ischemia; Cell death; Cardiovascular disease; Hypoxia

Perinatal hypoxic‐ischemic encephalopathy (HIE) is a significant cause of mortality and morbidity in infants and young children. Therapeutic opportunities are very limited for neonatal and pediatric HIE. Specific neural systems and populations of cells are selectively vulnerable in HIE; however, the...