Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors

Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. We evaluated 801 stroke- and dementia-free elderlies with baseline and...

Full description

Saved in:
Bibliographic Details
Published inAlzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 11; no. 1; pp. 721 - 729
Main Authors Lam, Bonnie Yin Ka, Leung, Kam Tat, Yiu, Brian, Zhao, Lei, Biesbroek, J. Matthijs, Au, Lisa, Tang, Yumi, Wang, Kai, Fan, Yuhua, Fu, Jian-Hui, Xu, Qun, Song, Haiqing, Tian, Xiaolin, Chu, Winnie Chiu Wing, Abrigo, Jill, Shi, Lin, Ko, Ho, Lau, Alexander, Duering, Marco, Wong, Adrian, Mok, Vincent Chung Tong
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2019
Elsevier
Wiley
Subjects
Community subjects
Diffusion tensor imaging
Neuroimaging
Peak width of skeletonized mean diffusivity
Processing speed
Small vessel disease
Peak width of skeletonized mean diffusivity
Processing speed
Small vessel disease
Community subjects
Diffusion tensor imaging
Online AccessGet full text

Cover

Abstract Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes. PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations.
AbstractList Abstract Introduction Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age‐related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods We evaluated 801 stroke‐ and dementia‐free elderlies with baseline and 3‐year follow‐up assessments. Regression analyses were used to assess the association between age‐related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age‐related cognitive outcomes. Results PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3‐year follow‐up. The association between vascular risk factors and age‐related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. Discussion PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age‐related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age‐related cognitive alterations.
Introduction Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age‐related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods We evaluated 801 stroke‐ and dementia‐free elderlies with baseline and 3‐year follow‐up assessments. Regression analyses were used to assess the association between age‐related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age‐related cognitive outcomes. Results PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3‐year follow‐up. The association between vascular risk factors and age‐related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. Discussion PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age‐related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age‐related cognitive alterations.
Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes. PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations.
Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors.INTRODUCTIONOnly two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors.We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes.METHODSWe evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes.PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers.RESULTSPSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers.PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations.DISCUSSIONPSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations.
Author Lam, Bonnie Yin Ka
Duering, Marco
Yiu, Brian
Chu, Winnie Chiu Wing
Abrigo, Jill
Song, Haiqing
Leung, Kam Tat
Tian, Xiaolin
Zhao, Lei
Fu, Jian-Hui
Wong, Adrian
Mok, Vincent Chung Tong
Au, Lisa
Ko, Ho
Biesbroek, J. Matthijs
Shi, Lin
Wang, Kai
Lau, Alexander
Tang, Yumi
Xu, Qun
Fan, Yuhua
AuthorAffiliation h Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
l Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
e Department of Neurology, The First Hospital of Anhui Medical University, Hefei, Anhui Province, China
k Department of Imaging and Interventional Radiology, Research Center for Medical Image Computing, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
g Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China
n Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
j Department of Neurology, The Second Affiliated Hospital, Tianjin Medical University, Tianjin, China
d Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands
i Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
o
AuthorAffiliation_xml – name: g Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China
– name: k Department of Imaging and Interventional Radiology, Research Center for Medical Image Computing, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– name: d Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands
– name: h Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
– name: f Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
– name: l Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– name: n Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
– name: o Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– name: c BrainNow Research Institute, Shenzhen, Guangdong Province, China
– name: m Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– name: a Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– name: b Therese Pei Fong Chow Research Center for Prevention of Dementia, Margaret Kam Ling Cheung Research Centre for Management of Parkinsonism, Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– name: e Department of Neurology, The First Hospital of Anhui Medical University, Hefei, Anhui Province, China
– name: j Department of Neurology, The Second Affiliated Hospital, Tianjin Medical University, Tianjin, China
– name: i Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
Author_xml – sequence: 1
  givenname: Bonnie Yin Ka
  surname: Lam
  fullname: Lam, Bonnie Yin Ka
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 2
  givenname: Kam Tat
  surname: Leung
  fullname: Leung, Kam Tat
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 3
  givenname: Brian
  surname: Yiu
  fullname: Yiu, Brian
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 4
  givenname: Lei
  surname: Zhao
  fullname: Zhao, Lei
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 5
  givenname: J. Matthijs
  surname: Biesbroek
  fullname: Biesbroek, J. Matthijs
  organization: Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands
– sequence: 6
  givenname: Lisa
  surname: Au
  fullname: Au, Lisa
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 7
  givenname: Yumi
  surname: Tang
  fullname: Tang, Yumi
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 8
  givenname: Kai
  surname: Wang
  fullname: Wang, Kai
  organization: Department of Neurology, The First Hospital of Anhui Medical University, Hefei, Anhui Province, China
– sequence: 9
  givenname: Yuhua
  surname: Fan
  fullname: Fan, Yuhua
  organization: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
– sequence: 10
  givenname: Jian-Hui
  surname: Fu
  fullname: Fu, Jian-Hui
  organization: Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China
– sequence: 11
  givenname: Qun
  surname: Xu
  fullname: Xu, Qun
  organization: Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
– sequence: 12
  givenname: Haiqing
  surname: Song
  fullname: Song, Haiqing
  organization: Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
– sequence: 13
  givenname: Xiaolin
  surname: Tian
  fullname: Tian, Xiaolin
  organization: Department of Neurology, The Second Affiliated Hospital, Tianjin Medical University, Tianjin, China
– sequence: 14
  givenname: Winnie Chiu Wing
  surname: Chu
  fullname: Chu, Winnie Chiu Wing
  organization: Department of Imaging and Interventional Radiology, Research Center for Medical Image Computing, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 15
  givenname: Jill
  surname: Abrigo
  fullname: Abrigo, Jill
  organization: Department of Imaging and Interventional Radiology, Research Center for Medical Image Computing, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 16
  givenname: Lin
  surname: Shi
  fullname: Shi, Lin
  organization: BrainNow Research Institute, Shenzhen, Guangdong Province, China
– sequence: 17
  givenname: Ho
  surname: Ko
  fullname: Ko, Ho
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 18
  givenname: Alexander
  surname: Lau
  fullname: Lau, Alexander
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 19
  givenname: Marco
  surname: Duering
  fullname: Duering, Marco
  organization: Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
– sequence: 20
  givenname: Adrian
  surname: Wong
  fullname: Wong, Adrian
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
– sequence: 21
  givenname: Vincent Chung Tong
  surname: Mok
  fullname: Mok, Vincent Chung Tong
  email: vctmok@cuhk.edu.hk
  organization: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31700990$$D View this record in MEDLINE/PubMed
BookMark eNqNkk1vEzEQQFeoiJbSP8AB7ZFLgj92vWsJIZWWQlERHOBsee1xOslm3dpOqnDqT8fJtqjlUCFZtmXPe2N55mWxN_gBiuI1JVNKqHg3n1ptl1NGqJySPAh_VhwwXrNJ2zC592C_XxzFOCeE0EqyipIXxT6nDSFSkoPi9gfoRXmDNl2W3pVxAT0kP-BvsOUS9FBadG4VcY1pU-rBlphiqWP0BnVCP2Q0k3oGkwC9TpkyfjZgwjWUuk8QdlFxh651NKtehzJgXJROm-RDfFU8d7qPcHS3Hha_zj79PPkyufj--fzk-GJiBGn5RDTAqsYYW4EwjLtGdIJxw7WtO3AtEY3kVdfU1LEaOqkb2dZSOFExaMAZ4IfF-ei1Xs_VVcClDhvlNardgQ8zpUNC04OS0BJd1XUtiamkI10rag5Va6qc00qdXR9G19WqW4I1MKSg-0fSxzcDXqqZXyvRMkkJy4K3d4Lgr1cQk1piNND3egC_iopxynkt6orm0DcPc_1Ncl_CHNCOASb4GAM4ZTDtfj2nxl5RorYNo-Zq2zBq2zCK5EF4Rtk_6L39SejjCN1gD5v_INTp8Sn7mqdv20MiR8n7UQK55GuEoKJBGAxYDGBSrgk-9YY_4u7v-w
CitedBy_id crossref_primary_10_1007_s11682_020_00394_4
crossref_primary_10_1002_acn3_51824
crossref_primary_10_3233_JAD_210358
crossref_primary_10_3389_fneur_2024_1461258
crossref_primary_10_3389_fnins_2022_1051038
crossref_primary_10_3389_fnins_2024_1473462
crossref_primary_10_2139_ssrn_3984250
crossref_primary_10_1111_epi_18205
crossref_primary_10_1002_alz_14345
crossref_primary_10_1097_CM9_0000000000001299
crossref_primary_10_1002_alz_13469
crossref_primary_10_3174_ajnr_A7042
crossref_primary_10_1007_s12264_022_00905_x
crossref_primary_10_1016_j_ejrad_2022_110441
crossref_primary_10_1016_j_neuroimage_2021_118381
crossref_primary_10_1148_radiol_212780
crossref_primary_10_1016_j_tjpad_2024_100037
Cites_doi 10.1007/s40473-015-0058-x
10.1016/j.bbadis.2011.08.003
10.1001/archneur.56.3.338
10.1177/0284185118795327
10.1016/j.neuropsychologia.2004.04.006
10.1159/000232589
10.1042/CS20170146
10.3389/fneur.2019.00081
10.1212/WNL.0000000000004594
10.1007/s10654-015-0105-7
10.1371/journal.pone.0147836
10.1016/j.neurobiolaging.2015.01.007
10.1111/jgs.12541
10.1016/0022-3956(75)90026-6
10.1016/j.cger.2013.07.002
10.1136/jnnp.2008.167288
10.1161/JAHA.117.005608
10.1159/000379744
10.1001/jama.2015.4380
10.1042/CS20160452
10.1002/ana.24758
10.1101/385013
10.1016/j.neuroimage.2009.10.035
10.1016/S1474-4422(13)70124-8
10.1212/WNL.50.4.1002
ContentType Journal Article
Copyright 2019 The Authors
2019 The Authors.
2019 The Authors 2019
Copyright_xml – notice: 2019 The Authors
– notice: 2019 The Authors.
– notice: 2019 The Authors 2019
DBID 6I.
AAFTH
24P
AAYXX
CITATION
NPM
7X8
5PM
DOA
DOI 10.1016/j.dadm.2019.09.003
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Wiley Online Library Open Access
CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList


MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: 24P
  name: Wiley Online Library Open Access
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 2352-8729
EndPage 729
ExternalDocumentID oai_doaj_org_article_9e80a455590c49f0b8653e48c4b62d9a
PMC6829102
31700990
10_1016_j_dadm_2019_09_003
DAD2JDADM201909003
S2352872919300703
Genre article
Journal Article
GrantInformation_xml – fundername: General Research Fund
  funderid: CUHK 471911
– fundername: National Key Research and Development Program of China
  funderid: 2016YFC1300600
GroupedDBID 0R~
0SF
1OC
24P
457
53G
6I.
7RV
7X7
8FI
8FJ
AACTN
AAEDW
AAFTH
AAHHS
AALRI
AAXUO
ABMAC
ABUWG
ACCFJ
ACGFS
ACXQS
ADBBV
ADEZE
ADKYN
ADPDF
ADRAZ
ADZMN
ADZOD
AEEZP
AEQDE
AEVXI
AEXQZ
AFKRA
AFTJW
AGHFR
AITUG
AIWBW
AJBDE
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
AOIJS
AVUZU
BAWUL
BENPR
CCPQU
EBS
EJD
EMOBN
FDB
FYUFA
GROUPED_DOAJ
HMCUK
HYE
IAO
INH
KQ8
M48
M~E
NAPCQ
NCXOZ
O9-
OK1
OVD
OVEED
PIMPY
ROL
RPM
SSZ
TEORI
UKHRP
WIN
ACCMX
ADVLN
ALIPV
ALUQN
IHR
ITC
AAYWO
AAYXX
CITATION
PHGZM
PHGZT
NPM
7X8
PPXIY
5PM
PUEGO
ID FETCH-LOGICAL-c6083-67e247ccd4e6c23f76b623c3ad5bef8067934b751f25eb9a798596f642e7efce3
IEDL.DBID M48
ISSN 2352-8729
IngestDate Wed Aug 27 01:31:23 EDT 2025
Thu Aug 21 14:35:14 EDT 2025
Fri Jul 11 10:16:42 EDT 2025
Wed Feb 19 02:27:04 EST 2025
Thu Apr 24 23:05:06 EDT 2025
Tue Jul 01 02:13:34 EDT 2025
Wed Jan 22 16:36:35 EST 2025
Fri Feb 23 02:49:48 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Peak width of skeletonized mean diffusivity
Processing speed
Small vessel disease
Community subjects
Diffusion tensor imaging
Language English
License This is an open access article under the CC BY-NC-ND license.
Attribution-NonCommercial-NoDerivs
2019 The Authors.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c6083-67e247ccd4e6c23f76b623c3ad5bef8067934b751f25eb9a798596f642e7efce3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1016/j.dadm.2019.09.003
PMID 31700990
PQID 2313356541
PQPubID 23479
PageCount 9
ParticipantIDs doaj_primary_oai_doaj_org_article_9e80a455590c49f0b8653e48c4b62d9a
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6829102
proquest_miscellaneous_2313356541
pubmed_primary_31700990
crossref_citationtrail_10_1016_j_dadm_2019_09_003
crossref_primary_10_1016_j_dadm_2019_09_003
wiley_primary_10_1016_j_dadm_2019_09_003_DAD2JDADM201909003
elsevier_sciencedirect_doi_10_1016_j_dadm_2019_09_003
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate December 2019
PublicationDateYYYYMMDD 2019-12-01
PublicationDate_xml – month: 12
  year: 2019
  text: December 2019
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Alzheimer's & dementia : diagnosis, assessment & disease monitoring
PublicationTitleAlternate Alzheimers Dement (Amst)
PublicationYear 2019
Publisher Elsevier Inc
Elsevier
Wiley
Publisher_xml – name: Elsevier Inc
– name: Elsevier
– name: Wiley
References Lam, Middleton Laura, Masellis, Stuss Donald, Harry Robin, Kiss (bib12) 2013; 61
Wei, Deng, Yao, Jia, Wang, Shi (bib7) 2019; 10
Deary, Ritchie, Maniega, Cox, Hernández, Starr (bib8) 2018
Baykara, Gesierich, Adam, Tuladhar, Biesbroek, Koek (bib6) 2016; 80
Zeestraten, Benjamin, Lambert, Lawrence, Williams, Morris (bib25) 2016; 11
Madden, Bennett, Burzynska, Potter, Chen, Song (bib4) 2012; 1822
Harada, Natelson Love, Triebel (bib3) 2013; 29
Dumas (bib1) 2015; 2
Zeestraten, Lawrence, Lambert, Benjamin, Brookes, Mackinnon (bib26) 2017; 89
Biesbroek, Weaver, Biessels (bib23) 2017; 131
Charlton, Schiavone, Barrick, Morris, Markus (bib22) 2010; 81
Wang, Wong, Liu, Yang, Chu, Au (bib24) 2015; 40
Abrigo, Shi, Luo, Chen, Chu, Mok (bib16) 2018; 60
Power, Tingle, Reid, Huang, Sharrett, Coresh (bib21) 2017; 6
Maillard, Carmichael, Reed, Mungas, DeCarli (bib9) 2015; 36
Burgmans, van Boxtel, Gronenschild, Vuurman, Hofman, Uylings (bib18) 2010; 49
Blazer, Yaffe, Karlawish (bib2) 2015; 313
Salat, Kaye, Janowsky (bib5) 1999; 56
Folstein, Folstein, McHugh (bib11) 1975; 12
Van Petten (bib17) 2004; 42
Wong, Xiong, Kwan, Chan, Lam, Wang (bib13) 2009; 28
Ikram, van der Lugt, Niessen, Koudstaal, Krestin, Hofman (bib20) 2015; 30
Croall, Lohner, Moynihan, Khan, Hassan, O'Brien (bib19) 2017; 131
Chiu, Lam, Leung, Li, Law, Chung (bib10) 1998; 50
Wardlaw, Smith, Biessels, Cordonnier, Fazekas, Frayne (bib15) 2013; 12
Smith (bib14) 1968
2015; 2
2013; 29
2017; 6
2015; 36
2004; 42
2019; 10
2012; 1822
2013; 61
2015; 30
2017; 89
1975; 12
2017; 131
2018; 60
2010; 81
2009; 28
2016; 11
2010; 49
2015; 313
2015; 40
2013; 12
1999; 56
2018
1998; 50
2016; 80
1968
e_1_2_7_5_2
e_1_2_7_4_2
e_1_2_7_3_2
e_1_2_7_2_2
e_1_2_7_9_2
e_1_2_7_8_2
e_1_2_7_7_2
e_1_2_7_6_2
e_1_2_7_19_2
e_1_2_7_18_2
e_1_2_7_16_2
e_1_2_7_14_2
e_1_2_7_13_2
Smith A. (e_1_2_7_15_2) 1968
Abrigo J. (e_1_2_7_17_2) 2018; 60
e_1_2_7_12_2
Wang Z. (e_1_2_7_25_2) 2015; 40
e_1_2_7_11_2
e_1_2_7_10_2
e_1_2_7_26_2
e_1_2_7_27_2
e_1_2_7_24_2
e_1_2_7_23_2
e_1_2_7_22_2
e_1_2_7_21_2
e_1_2_7_20_2
References_xml – year: 1968
  ident: bib14
  article-title: The Symbol-Digit Modalities Test: A Neuropsychologic Test of Learning and Other Cerebral Disorders
– volume: 1822
  start-page: 386
  year: 2012
  end-page: 400
  ident: bib4
  article-title: Diffusion tensor imaging of cerebral white matter integrity in cognitive aging
  publication-title: Biochim Biophys Acta
– volume: 89
  start-page: 1869
  year: 2017
  end-page: 1876
  ident: bib26
  article-title: Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease
  publication-title: Neurology
– volume: 131
  start-page: 1361
  year: 2017
  end-page: 1373
  ident: bib19
  article-title: Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies
  publication-title: Clin Sci
– volume: 131
  start-page: 715
  year: 2017
  end-page: 728
  ident: bib23
  article-title: Lesion location and cognitive impact of cerebral small vessel disease
  publication-title: Clin Sci
– volume: 50
  start-page: 1002
  year: 1998
  end-page: 1009
  ident: bib10
  article-title: Prevalence of dementia in Chinese elderly in Hong Kong
  publication-title: Neurology
– volume: 2
  start-page: 256
  year: 2015
  end-page: 261
  ident: bib1
  article-title: What is normal cognitive aging? Evidence from task-based functional neuroimaging
  publication-title: Curr Behav Neurosci Rep
– start-page: 385013
  year: 2018
  ident: bib8
  article-title: Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains
  publication-title: bioRxiv
– volume: 81
  start-page: 13
  year: 2010
  end-page: 19
  ident: bib22
  article-title: Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline
  publication-title: J Neurol Neurosurg Psychiatry
– volume: 11
  start-page: e0147836
  year: 2016
  ident: bib25
  article-title: Application of diffusion tensor imaging parameters to detect change in longitudinal studies in cerebral small vessel disease
  publication-title: PLoS One
– volume: 6
  year: 2017
  ident: bib21
  article-title: Midlife and late-life vascular risk factors and white matter microstructural integrity: the atherosclerosis risk in communities neurocognitive study
  publication-title: J Am Heart Assoc
– volume: 10
  start-page: 81
  year: 2019
  ident: bib7
  article-title: A neuroimaging marker based on diffusion tensor imaging and cognitive impairment due to cerebral white matter lesions
  publication-title: Front Neurol
– volume: 42
  start-page: 1394
  year: 2004
  end-page: 1413
  ident: bib17
  article-title: Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis
  publication-title: Neuropsychologia
– volume: 12
  start-page: 189
  year: 1975
  end-page: 198
  ident: bib11
  article-title: “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician
  publication-title: J Psychiatr Res
– volume: 28
  start-page: 81
  year: 2009
  end-page: 87
  ident: bib13
  article-title: The validity, reliability and clinical utility of the Hong Kong Montreal Cognitive Assessment (HK-MoCA) in patients with cerebral small vessel disease
  publication-title: Demen Geriatr Cogn Disord
– volume: 313
  start-page: 2121
  year: 2015
  end-page: 2122
  ident: bib2
  article-title: Cognitive aging: a report from the Institute of Medicine
  publication-title: JAMA
– volume: 36
  start-page: 1670
  year: 2015
  end-page: 1677
  ident: bib9
  article-title: Co-Occurrence of vascular risk factors and late-life white matter integrity changes
  publication-title: Neurobiol Aging
– volume: 49
  start-page: 2083
  year: 2010
  end-page: 2093
  ident: bib18
  article-title: Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension
  publication-title: NeuroImage
– volume: 60
  start-page: 769
  year: 2018
  end-page: 776
  ident: bib16
  article-title: Standardization of hippocampus volumetry using automated brain structure volumetry tool for an initial Alzheimer's disease imaging biomarker
  publication-title: Acta Radiologica
– volume: 29
  start-page: 737
  year: 2013
  end-page: 752
  ident: bib3
  article-title: Normal cognitive aging
  publication-title: Clin Geriatr Med
– volume: 12
  start-page: 822
  year: 2013
  end-page: 838
  ident: bib15
  article-title: Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
  publication-title: Lancet Neurol
– volume: 56
  start-page: 338
  year: 1999
  end-page: 344
  ident: bib5
  article-title: Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease
  publication-title: Arch Neurol
– volume: 30
  start-page: 1299
  year: 2015
  end-page: 1315
  ident: bib20
  article-title: The Rotterdam Scan Study: design update 2016 and main findings
  publication-title: Eur J Epidemiol
– volume: 61
  start-page: 2181
  year: 2013
  end-page: 2185
  ident: bib12
  article-title: Criterion and convergent validity of the montreal cognitive assessment with screening and standardized neuropsychological testing
  publication-title: J Am Geriatr Soc
– volume: 80
  start-page: 581
  year: 2016
  end-page: 592
  ident: bib6
  article-title: A novel imaging marker for small vessel disease based on skeletonization of white matter tracts and diffusion histograms
  publication-title: Ann Neurol
– volume: 40
  start-page: 130
  year: 2015
  end-page: 136
  ident: bib24
  article-title: Cerebral microbleeds and cognitive function in ischemic stroke or transient ischemic attack patients
  publication-title: Demen Geriatr Cogn Disord
– volume: 60
  start-page: 769
  year: 2018
  end-page: 776
  article-title: Standardization of hippocampus volumetry using automated brain structure volumetry tool for an initial Alzheimer's disease imaging biomarker
  publication-title: Acta Radiologica
– volume: 89
  start-page: 1869
  year: 2017
  end-page: 1876
  article-title: Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease
  publication-title: Neurology
– start-page: 385013
  year: 2018
  article-title: Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains
– volume: 81
  start-page: 13
  year: 2010
  end-page: 19
  article-title: Diffusion tensor imaging detects age related white matter change over a 2 year follow‐up which is associated with working memory decline
  publication-title: J Neurol Neurosurg Psychiatry
– volume: 12
  start-page: 189
  year: 1975
  end-page: 198
  article-title: “Mini‐mental state”: a practical method for grading the cognitive state of patients for the clinician
  publication-title: J Psychiatr Res
– volume: 10
  start-page: 81
  year: 2019
  article-title: A neuroimaging marker based on diffusion tensor imaging and cognitive impairment due to cerebral white matter lesions
  publication-title: Front Neurol
– volume: 11
  year: 2016
  article-title: Application of diffusion tensor imaging parameters to detect change in longitudinal studies in cerebral small vessel disease
  publication-title: PLoS One
– year: 1968
– volume: 12
  start-page: 822
  year: 2013
  end-page: 838
  article-title: Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
  publication-title: Lancet Neurol
– volume: 49
  start-page: 2083
  year: 2010
  end-page: 2093
  article-title: Multiple indicators of age‐related differences in cerebral white matter and the modifying effects of hypertension
  publication-title: NeuroImage
– volume: 1822
  start-page: 386
  year: 2012
  end-page: 400
  article-title: Diffusion tensor imaging of cerebral white matter integrity in cognitive aging
  publication-title: Biochim Biophys Acta
– volume: 42
  start-page: 1394
  year: 2004
  end-page: 1413
  article-title: Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta‐analysis
  publication-title: Neuropsychologia
– volume: 29
  start-page: 737
  year: 2013
  end-page: 752
  article-title: Normal cognitive aging
  publication-title: Clin Geriatr Med
– volume: 56
  start-page: 338
  year: 1999
  end-page: 344
  article-title: Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease
  publication-title: Arch Neurol
– volume: 61
  start-page: 2181
  year: 2013
  end-page: 2185
  article-title: Criterion and convergent validity of the montreal cognitive assessment with screening and standardized neuropsychological testing
  publication-title: J Am Geriatr Soc
– volume: 80
  start-page: 581
  year: 2016
  end-page: 592
  article-title: A novel imaging marker for small vessel disease based on skeletonization of white matter tracts and diffusion histograms
  publication-title: Ann Neurol
– volume: 131
  start-page: 1361
  year: 2017
  end-page: 1373
  article-title: Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies
  publication-title: Clin Sci
– volume: 6
  year: 2017
  article-title: Midlife and late‐life vascular risk factors and white matter microstructural integrity: the atherosclerosis risk in communities neurocognitive study
  publication-title: J Am Heart Assoc
– volume: 40
  start-page: 130
  year: 2015
  end-page: 136
  article-title: Cerebral microbleeds and cognitive function in ischemic stroke or transient ischemic attack patients
  publication-title: Demen Geriatr Cogn Disord
– volume: 2
  start-page: 256
  year: 2015
  end-page: 261
  article-title: What is normal cognitive aging? Evidence from task‐based functional neuroimaging
  publication-title: Curr Behav Neurosci Rep
– volume: 36
  start-page: 1670
  year: 2015
  end-page: 1677
  article-title: Co‐Occurrence of vascular risk factors and late‐life white matter integrity changes
  publication-title: Neurobiol Aging
– volume: 28
  start-page: 81
  year: 2009
  end-page: 87
  article-title: The validity, reliability and clinical utility of the Hong Kong Montreal Cognitive Assessment (HK‐MoCA) in patients with cerebral small vessel disease
  publication-title: Demen Geriatr Cogn Disord
– volume: 50
  start-page: 1002
  year: 1998
  end-page: 1009
  article-title: Prevalence of dementia in Chinese elderly in Hong Kong
  publication-title: Neurology
– volume: 313
  start-page: 2121
  year: 2015
  end-page: 2122
  article-title: Cognitive aging: a report from the Institute of Medicine
  publication-title: JAMA
– volume: 30
  start-page: 1299
  year: 2015
  end-page: 1315
  article-title: The Rotterdam Scan Study: design update 2016 and main findings
  publication-title: Eur J Epidemiol
– volume: 131
  start-page: 715
  year: 2017
  end-page: 728
  article-title: Lesion location and cognitive impact of cerebral small vessel disease
  publication-title: Clin Sci
– volume-title: The Symbol‐Digit Modalities Test: A Neuropsychologic Test of Learning and Other Cerebral Disorders
  year: 1968
  ident: e_1_2_7_15_2
– ident: e_1_2_7_2_2
  doi: 10.1007/s40473-015-0058-x
– ident: e_1_2_7_5_2
  doi: 10.1016/j.bbadis.2011.08.003
– ident: e_1_2_7_6_2
  doi: 10.1001/archneur.56.3.338
– volume: 60
  start-page: 769
  year: 2018
  ident: e_1_2_7_17_2
  article-title: Standardization of hippocampus volumetry using automated brain structure volumetry tool for an initial Alzheimer's disease imaging biomarker
  publication-title: Acta Radiologica
  doi: 10.1177/0284185118795327
– ident: e_1_2_7_18_2
  doi: 10.1016/j.neuropsychologia.2004.04.006
– ident: e_1_2_7_14_2
  doi: 10.1159/000232589
– ident: e_1_2_7_20_2
  doi: 10.1042/CS20170146
– ident: e_1_2_7_8_2
  doi: 10.3389/fneur.2019.00081
– ident: e_1_2_7_27_2
  doi: 10.1212/WNL.0000000000004594
– ident: e_1_2_7_21_2
  doi: 10.1007/s10654-015-0105-7
– ident: e_1_2_7_26_2
  doi: 10.1371/journal.pone.0147836
– ident: e_1_2_7_10_2
  doi: 10.1016/j.neurobiolaging.2015.01.007
– ident: e_1_2_7_13_2
  doi: 10.1111/jgs.12541
– ident: e_1_2_7_12_2
  doi: 10.1016/0022-3956(75)90026-6
– ident: e_1_2_7_4_2
  doi: 10.1016/j.cger.2013.07.002
– ident: e_1_2_7_23_2
  doi: 10.1136/jnnp.2008.167288
– ident: e_1_2_7_22_2
  doi: 10.1161/JAHA.117.005608
– volume: 40
  start-page: 130
  year: 2015
  ident: e_1_2_7_25_2
  article-title: Cerebral microbleeds and cognitive function in ischemic stroke or transient ischemic attack patients
  publication-title: Demen Geriatr Cogn Disord
  doi: 10.1159/000379744
– ident: e_1_2_7_3_2
  doi: 10.1001/jama.2015.4380
– ident: e_1_2_7_24_2
  doi: 10.1042/CS20160452
– ident: e_1_2_7_7_2
  doi: 10.1002/ana.24758
– ident: e_1_2_7_9_2
  doi: 10.1101/385013
– ident: e_1_2_7_19_2
  doi: 10.1016/j.neuroimage.2009.10.035
– ident: e_1_2_7_16_2
  doi: 10.1016/S1474-4422(13)70124-8
– ident: e_1_2_7_11_2
  doi: 10.1212/WNL.50.4.1002
SSID ssj0001492410
Score 2.287175
Snippet Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none...
Introduction Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age‐related cognitive alterations,...
Abstract Introduction Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age‐related cognitive...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
wiley
elsevier
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 721
SubjectTerms Community subjects
Diffusion tensor imaging
Neuroimaging
Peak width of skeletonized mean diffusivity
Processing speed
Small vessel disease
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQiFd4yUjcUEQSP2KLU6FUVaVyolJvlp9qWsgidldInBC_gN_IL2HGTpZdVSocuOSQxE4yHnu-cWa-IeSFi9zDBOR1K12qudCpVkkLzEYD_1lxpzrMdz55L49O-fGZONsq9YUxYYUeuAjulY6qsVwA8G0816lxSgoWufLcyS7oDI3A5m05UxcF94NpaqYsmRLQFWzA1PNWZ2LTuUrWZIkyYf-OQboKOK_GTW7j2WyQDm-TWxOSpPvlC-6QG3G8S37AEndJvw5hdU4XiS4vwaoAuhu-xUA_RTtSLIiyXuaKEdSOgQ6rJbV_hojiviyFNebX9585zQXabSKMaP61Xrb4cuM5jJVigDqdSvfcI6eH7z68PaqnMgu1lwDAatnHjvfeBx6l71jqJUiWeWaDcDEp3Gli3PWiTZ2ITtteK6FlAscl9jH5yO6TvXExxoeEhtY12iYXZet4iNpJcL-Chha9Dpw3FWlnkRs_cZBjKYyPZg42uzA4TAaHyTQamUsr8nLT5nNh4Lj27jc4kps7kT07nwCdMpNOmb_pVEXErAdmAiIFYEBXw7UPfz4rjYFZir9e7BgX66UBFM2YwJrrFXlQlGjzigwpEgEUVKTfUa-db9i9Mg7nmQlcqg7gXleR11kR_0E-5mD_oDuGwwmebHAf-9H_ENljchM7LIE-T8je6ss6PgW4tnLP8sz8DdkHPcw
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Wiley Online Library Open Access
  dbid: 24P
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ba9VAEF5KffFFlHqJl7KCbxJINrubLD5Vj6UUKj5Y6NuyV3tazSnNOQg-ib_A3-gvcWZzaWOhCL6EkJNJTrIzu99MZr4h5JUN3IEB8ryUNuZcqJg3UQmsRgP_ueG2YVjvfPRBHhzzwxNxskUWYy1Mzw8xBdzQMtJ8jQZubHfN3zwDl9hjLXmpElMpUn7ewRpbZNBn_ONVpIWDj5FoCRigDTB_pobqmT7R6-_LzFaoROQ_W6huAtGb-ZTXcW5aqPbvk3sDwqR7vUo8IFuh3SE_Yeo7p9-Wfn1KV5F257DaAOpbfg-efg2mpdgoZdOlThLUtJ4u1x01V0NHMV5LYe75_eNXKn8BuSnziKZP7n3oLwmP6a0UE9fp0NLnITnef__p3UE-tF_InQRglss6MF4753mQjlWxlhawkquMFzbEBiNQFbe1KCMTwSpTq0YoGcGhCXWILlSPyHa7asMTQn1pC2WiDbK03AdlJbhlXoFErTznRUbK8ZVrN3CTY4uML3pMQjvTOEwah0kXChlNM_J6krnomTluPfstjuR0JrJqpwOry896MFKtQlMYLsDJKhxXsbCNFFXgjePw5F6ZjIhRD_QAUHrgAZda3nrzl6PSaLBe_CRj2rDadBrQdVUJ7MWekce9Ek1_sULqRAALGaln6jV7hvkv7fI0MYTLhgEMZBl5kxTxH96PXuwt2CFsjvBggfHtp_8l_Yzcxf0-8-c52V5fbsILwG9ru5vM8w9iLj7f
  priority: 102
  providerName: Wiley-Blackwell
Title Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors
URI https://dx.doi.org/10.1016/j.dadm.2019.09.003
https://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.dadm.2019.09.003
https://www.ncbi.nlm.nih.gov/pubmed/31700990
https://www.proquest.com/docview/2313356541
https://pubmed.ncbi.nlm.nih.gov/PMC6829102
https://doaj.org/article/9e80a455590c49f0b8653e48c4b62d9a
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Za9wwEBZpAiUvpaWXeywq9K24-NBhUUpJmoQQ2BBKF_ZNWJbUOEm97XqXHk_96Z2R7U2WhFD64gfZ40Oa0XwznoOQ18axCgSQxakwPmZc-bjwimM2GtjPBTNFhvnO42NxOGFHUz7dIEO7o34C2xtNO-wnNZlfvP35_dcHEPj3l7FatrSYVZ6qULMUi39ugWaSKKjjHu6fddYADCd97szNpNvkbo4168IufUVVhYr-axrrOiK9Hlh5FfAGjXVwn9zroSbd6XjjAdlwzUPyB_bAc_qjtotTOvO0PQe1A_Cv_u0s_erKhmLHlGUbWkrQsrG0XrS0vFxDio5bCptQHLJggGoVgETDn_fOAxhIhyhXivHrtO_s84hMDvY_fzyM-y4McSUAn8VCuozJqrLMiSrLvRQGIFOVl5Yb5wt0ROXMSJ76jDujSqkKroQHu8ZJ5yuXPyabzaxxTwm1qUlU6Y0TqWHWKSPAOrMKKKSyjCURSYcJ11Vfohw7ZVzoIRbtTON6aVwvnSgsbBqRNyuab12Bjluv3sV1XF2JxbXDwGz-RfeyqpUrkpJxsLWSiimfmELw3LGiYvDlVpUR4QMX6B6ndPgDblXf-vBXA8toEGL8M1M2brZsNYDsPOfYkj0iTzoWWr3iwI0RkWvMtfYN62ea-jQUChdFBmgwi8i7wIb_MD96b2cvO4LDGAcTdHM_--_nPifbeJcu-OcF2VzMl-4lQLiFGZE7GTuBo5zKEdna3T8--TQK7pBRkNi_FGRJgg
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaqcoALAvEKTyNxQ5ESx3ZicSq01VK6FYdW6s2KXzQtZFF3V0icEL-A38gvYcZ5tKFShcQlByeT3cQz9jeTmW8IeWU8t2CAPM2lCSkXKqRVUAKr0cB_rripGNY7zw_k7IjvHYvjDbIz1MJ0_BBjwA0tI67XaOAYkL7kcJ6CT-ywmDxXkaoUOT9vcMlKtE_GP16EWjg4GZGXgAHcAPtnqi-f6TK9_r7NZIuKTP6TneoqEr2aUHkZ6MadavcOud1DTLrV6cRdsuHbe-QnrH1n9FvjVid0EejyDLYbgH3Nd-_oF1-3FDulrJexlQStW0eb1ZLWF3NHMWBLYfH5_eNXrH8BuTH1iMZv7l3sLwoP-a0UM9dp39PnPjna3Tl8N0v7_guplYDMUll6xktrHffSsiKU0gBYskXthPGhwhBUwU0p8sCEN6ouVSWUDODR-NIH64sHZLNdtP4RoS43maqD8TI33HllJPhlToFEqRznWULy4ZVr25OTY4-Mz3rIQjvVOE0ap0lnCilNE_J6lPnaUXNce_VbnMnxSqTVjgOL80-6t1KtfJXVXICXlVmuQmYqKQrPK8vhyZ2qEyIGPdA9QumQB9yqufbHXw5Ko8F88ZtM3frFeqkBXheFwGbsCXnYKdH4FwvkTgS0kJByol6TZ5ieaZuTSBEuKwY4kCXkTVTEf3g_entrm-3BYY6DGQa4H_-X9Atyc3Y439f77w8-PCG3cLxLA3pKNlfna_8MwNzKPI-m-geFqkJL
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaqVkJcUBGv8DQSNxQpD9uJ1dPCsiqFVhxYVHGx4lebFrJVd1dInBC_gN_IL2HGebShUoXEJQcnk93EM_Y3k5lvCHmhHTNggCxOhfYx49LHpZccq9HAfy6ZLjOsd94_ELtztnfIDzfItK-FafkhhoAbWkZYr9HAz6y_5G-egEtssZY8lYGpFCk_t5AuD3R7a_Jp_nl-EWth4GUEYoIM8AYsAJns6mfaVK-_bzTaowKV_2irugpFr2ZUXka6YauabZNbHcakk1YpbpMN19whP2HxO6Xfars6pgtPl6ew3wDuq787S7-6qqHYKmW9DL0kaNVYWq-WtLqYPIoRWwqrz-8fv0IBDMgNuUc0fHRvg39BuE9wpZi6TrumPnfJfPbm4-vduGvAEBsB0CwWhctYYYxlTpgs94XQgJZMXlmunS8xBpUzXfDUZ9xpWRWy5FJ4cGlc4bxx-T2y2Swa94BQm-pEVl47kWpmndQCHDMrQaKQlrEkImn_ypXp2MmxScYX1aehnSicJoXTpBKJnKYReTnInLXcHNde_QpncrgSebXDwOL8SHVmqqQrk4pxcLMSw6RPdCl47lhpGDy5lVVEeK8HqoMoLfSAW9XX_vjzXmkU2C9-lKkat1gvFeDrPOfYjT0i91slGv5ijuSJABciUozUa_QM4zNNfRw4wkWZARDMIrITFPEf3o-aTqbZHhz2cTDBCPfD_5J-Rm58mM7U-7cH7x6RmzjcpgE9Jpur87V7AmBupZ92tvoHbKRDQw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Peak+width+of+skeletonized+mean+diffusivity+and+its+association+with+age-related+cognitive+alterations+and+vascular+risk+factors&rft.jtitle=Alzheimer%27s+%26+dementia+%3A+diagnosis%2C+assessment+%26+disease+monitoring&rft.au=Lam%2C+Bonnie+Yin+Ka&rft.au=Leung%2C+Kam+Tat&rft.au=Yiu%2C+Brian&rft.au=Zhao%2C+Lei&rft.date=2019-12-01&rft.pub=Elsevier&rft.eissn=2352-8729&rft.volume=11&rft.spage=721&rft.epage=729&rft_id=info:doi/10.1016%2Fj.dadm.2019.09.003&rft_id=info%3Apmid%2F31700990&rft.externalDocID=PMC6829102
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2352-8729&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2352-8729&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2352-8729&client=summon