甲苯磺酸多纳非尼治疗原发性肝癌长期缓解2例报告
原发性肝癌在肿瘤相关性死亡中排第3位,由于起病隐匿、进展迅速,临床上仅有不足30%的患者就诊时可获得手术治疗的机会,因此,非手术疗法是中晚期肝癌的主要治疗方式。目前以索拉非尼为代表的激酶抑制剂成为第一个治疗原发性肝癌的靶向治疗药物。甲苯磺酸多纳非尼将索拉非尼分子上的一个甲基取代为三氘代甲基后形成全新结构的新药,与索拉非尼具有相似的分子结构和作用机制。笔者在多纳非尼的ⅠB期临床试验中,...
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| Published in | 临床肝胆病杂志 Vol. 33; no. 4; pp. 730 - 731 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
吉林大学第一医院肝胆胰内科,长春,130021%吉林大学第一医院干部病房,长春,130021%吉林大学第一医院信息中心,长春,130021
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2017.04.028 |
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| Abstract | 原发性肝癌在肿瘤相关性死亡中排第3位,由于起病隐匿、进展迅速,临床上仅有不足30%的患者就诊时可获得手术治疗的机会,因此,非手术疗法是中晚期肝癌的主要治疗方式。目前以索拉非尼为代表的激酶抑制剂成为第一个治疗原发性肝癌的靶向治疗药物。甲苯磺酸多纳非尼将索拉非尼分子上的一个甲基取代为三氘代甲基后形成全新结构的新药,与索拉非尼具有相似的分子结构和作用机制。笔者在多纳非尼的ⅠB期临床试验中, |
|---|---|
| AbstractList | 原发性肝癌在肿瘤相关性死亡中排第3位,由于起病隐匿、进展迅速,临床上仅有不足30%的患者就诊时可获得手术治疗的机会,因此,非手术疗法是中晚期肝癌的主要治疗方式。目前以索拉非尼为代表的激酶抑制剂成为第一个治疗原发性肝癌的靶向治疗药物。甲苯磺酸多纳非尼将索拉非尼分子上的一个甲基取代为三氘代甲基后形成全新结构的新药,与索拉非尼具有相似的分子结构和作用机制。笔者在多纳非尼的ⅠB期临床试验中, R735.7; @@ |
| Author | 胡月 娄金凤 刘景瑞 丁艳华 马云 牛俊奇 |
| AuthorAffiliation | 吉林大学第一医院肝胆胰内科,长春130021 吉林大学第一医院干部病房,长春130021 吉林大学第一医院信息中心,长春130021 |
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| DocumentTitleAlternate | Long - term relief in patients with hepatocellular carcinoma treated with donafenib tosylate： a report of two cases |
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| Keywords | 肝肿瘤 liver neoplasms targeted therapy case reports 病例报告 靶向治疗 |
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| Notes | HU Yue, LOU Jinfeng, LIU Jingrui, et al. （Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China） liver neoplasms ; targeted therapy ; case reports 22-1108/R |
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| Publisher | 吉林大学第一医院肝胆胰内科,长春,130021%吉林大学第一医院干部病房,长春,130021%吉林大学第一医院信息中心,长春,130021 |
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| Title | 甲苯磺酸多纳非尼治疗原发性肝癌长期缓解2例报告 |
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