Duchenne型肌营养不良心脏损害研究进展
Duchenlie型肌营养不良是儿童致死性肌萎缩疾病，病情进展迅速，如无系统治疗，患儿多于20岁前死于呼吸循环衰竭。Duchenile型肌营养不良对心脏的不良影响日益凸显，推测与dystrophin基因特定外显子缺失密切相关。本文拟对Duchenne型肌营养不良心脏损害的流行病学、与dystrophin基因关系、发生机制、临床表现和病理特征，以及早期预防与治疗进行综述。...
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| Published in | 中国现代神经疾病杂志 Vol. 13; no. 5; pp. 453 - 456 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
150001,哈尔滨医科大学附属第一医院神经内科%中山大学附属第一医院神经科,广州,510080
2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-6731 |
| DOI | 10.3969/j.issn.1672-6731.2013.05.018 |
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| Abstract | Duchenlie型肌营养不良是儿童致死性肌萎缩疾病，病情进展迅速，如无系统治疗，患儿多于20岁前死于呼吸循环衰竭。Duchenile型肌营养不良对心脏的不良影响日益凸显，推测与dystrophin基因特定外显子缺失密切相关。本文拟对Duchenne型肌营养不良心脏损害的流行病学、与dystrophin基因关系、发生机制、临床表现和病理特征，以及早期预防与治疗进行综述。 |
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| AbstractList | Duchenne型肌营养不良是儿童致死性肌萎缩疾病,病情进展迅速,如无系统治疗,患儿多于20岁前死于呼吸循环衰竭.Duchenne型肌营养不良对心脏的不良影响日益凸显,推测与dystrophin基因特定外显子缺失密切相关.本文拟对Duchenne型肌营养不良心脏损害的流行病学、与dystrophin基因关系、发生机制、临床表现和病理特征,以及早期预防与治疗进行综述. Duchenlie型肌营养不良是儿童致死性肌萎缩疾病，病情进展迅速，如无系统治疗，患儿多于20岁前死于呼吸循环衰竭。Duchenile型肌营养不良对心脏的不良影响日益凸显，推测与dystrophin基因特定外显子缺失密切相关。本文拟对Duchenne型肌营养不良心脏损害的流行病学、与dystrophin基因关系、发生机制、临床表现和病理特征，以及早期预防与治疗进行综述。 |
| Author | 张瑶 汤颖 张成 |
| AuthorAffiliation | 哈尔滨医科大学附属第一医院神经内科,150001 中山大学附属第一医院神经科,广州510080 |
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| Author_FL | ZHANG Yao TANG Ying ZHANG Cheng |
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| Author_xml | – sequence: 1 fullname: 张瑶 汤颖 张成 |
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| DocumentTitleAlternate | Progress study of the cardiac damage in Duchenne muscular dystrophy |
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| EndPage | 456 |
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| Keywords | 综述 肌营养不良,杜氏 肌营养不良蛋白 心脏病 |
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| Notes | Duchenne muscular dystrophy （DMD） is a fatal muscular disease with rapid progression in children. Most patients die of respiratory and circulatory failure before the age of 20 if there is no systematic treatment. Now the heart problem in this disease has become increasingly prominent, and is thought to be closely associated with certain dystrophin exon deletion. We would like to review the epidemiology, relevance of dystrophin, pathogenesis, clinical manifestations and pathological features, as well as early prevention and treatment of DMD. Muscular dystrophy, Duchenne; Dystrophin; Heart diseases; Review ZHANG Yao, TANG Ying, ZHANG Cheng（ 1 Department of Neurology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China 2Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China） 12-1363/R |
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| PublicationTitle | 中国现代神经疾病杂志 |
| PublicationTitleAlternate | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| PublicationYear | 2013 |
| Publisher | 150001,哈尔滨医科大学附属第一医院神经内科%中山大学附属第一医院神经科,广州,510080 |
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| SubjectTerms | 心脏病 杜氏 综述 肌营养不良 肌营养不良蛋白 |
| Title | Duchenne型肌营养不良心脏损害研究进展 |
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