Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis
Background Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigate...
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| Published in | Environmental health Vol. 19; no. 1; pp. 104 - 22 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
02.10.2020
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1476-069X 1476-069X |
| DOI | 10.1186/s12940-020-00659-x |
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| Abstract | Background
Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker.
Methods
We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators.
Results
Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6–18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), − 4.58, − 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L).
Conclusions
Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6–18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study. |
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| AbstractList | Background Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker. Methods We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators. Results Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6–18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), − 4.58, − 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L). Conclusions Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6–18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study. Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker. We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators. Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6-18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), - 4.58, - 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L). Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6-18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study. Background Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker. Methods We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators. Results Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6-18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 [mu]g/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), - 4.58, - 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 [mu]g/L). Conclusions Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6-18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study. Keywords: Manganese exposure, Biomarker, Cognitive function, Behavior, Motor Background Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker. Methods We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators. Results Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6–18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), − 4.58, − 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L). Conclusions Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6–18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study. Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker. We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators. Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6-18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 [mu]g/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), - 4.58, - 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 [mu]g/L). Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6-18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study. Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker.BACKGROUNDAlthough prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker.We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators.METHODSWe searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators.Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6-18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), - 4.58, - 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L).RESULTSOf 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6-18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), - 4.58, - 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L).Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6-18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study.CONCLUSIONSHigher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6-18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study. Abstract Background Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker. Methods We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators. Results Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6–18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), − 4.58, − 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L). Conclusions Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6–18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study. |
| ArticleNumber | 104 |
| Audience | Academic |
| Author | Liu, Weiwei Ping, Zhiguang Min, Junxia Li, Qianwen Shang, Yanna Cahill, Catherine M. Wang, Fudi Rogers, Jack T. Xin, Yongjuan |
| Author_xml | – sequence: 1 givenname: Weiwei surname: Liu fullname: Liu, Weiwei organization: Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University – sequence: 2 givenname: Yongjuan surname: Xin fullname: Xin, Yongjuan organization: Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University – sequence: 3 givenname: Qianwen surname: Li fullname: Li, Qianwen organization: Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University – sequence: 4 givenname: Yanna surname: Shang fullname: Shang, Yanna organization: Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University – sequence: 5 givenname: Zhiguang surname: Ping fullname: Ping, Zhiguang organization: Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University – sequence: 6 givenname: Junxia surname: Min fullname: Min, Junxia organization: The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine – sequence: 7 givenname: Catherine M. surname: Cahill fullname: Cahill, Catherine M. organization: Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital and Harvard Medical School – sequence: 8 givenname: Jack T. surname: Rogers fullname: Rogers, Jack T. email: jack.rogers@mgh.harvard.edu organization: Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital and Harvard Medical School – sequence: 9 givenname: Fudi orcidid: 0000-0001-8730-0003 surname: Wang fullname: Wang, Fudi email: fwang@zju.edu.cn organization: Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33008482$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.envres.2013.03.003 10.1016/j.envres.2014.04.012 10.1016/j.neuro.2013.09.006 10.1038/jes.2015.45 10.1016/j.neuro.2017.09.001 10.1289/ehp.1002321 10.1016/j.ntt.2006.09.020 10.1016/j.scitotenv.2017.11.273 10.1017/CBO9781139170697 10.1186/s12940-019-0505-3 10.1371/journal.pgen.1006892 10.1016/j.envres.2012.10.007 10.1016/j.neuro.2010.10.002 10.1289/ehp.1307918 10.1016/j.neuro.2011.03.009 10.1007/s12011-019-01703-9 10.1021/es203569f 10.1016/S0161-813X(03)00058-5 10.1016/j.yfrne.2010.10.001 10.1016/j.neuro.2016.10.006 10.1016/j.scitotenv.2013.03.047 10.1016/j.envres.2015.01.019 10.1016/j.scitotenv.2010.06.041 10.1007/b97447 10.1016/j.chemosphere.2016.07.095 10.1080/19338244.2012.725229 10.1016/j.tox.2019.03.004 10.1289/ehp.1307865 10.1016/j.ntt.2013.12.005 10.1016/j.neuro.2005.10.001 10.3390/ijms20040994 10.1016/j.neuro.2019.04.004 10.1097/EDE.0b013e3181df8e52 10.1172/JCI105760 10.3390/ijerph120707519 10.1007/s11356-016-6420-z 10.1111/j.1468-3083.2009.03426.x 10.1016/j.scitotenv.2010.12.018 10.1289/ehp.0901229 10.1289/EHP1955 10.1186/s12877-018-0798-z 10.1016/j.envres.2013.05.006 10.1016/j.envres.2017.08.035 10.1016/j.neuro.2009.03.012 10.1016/j.envint.2017.08.013 10.1289/ehp.1408993 10.2147/NDT.S165378 10.1016/j.neuro.2017.06.006 10.1016/j.envint.2015.07.009 10.1186/s12940-016-0127-y 10.1385/BTER:104:3:215 10.1016/j.toxlet.2007.10.003 10.1016/j.neuro.2017.09.003 10.1016/j.envres.2012.08.003 10.1016/j.neuro.2011.12.002 10.1093/toxsci/kfp198 10.1289/ehp.9504 10.1186/s12940-016-0174-4 10.1038/ncomms11601 10.1016/j.neuro.2013.11.006 10.1136/bmj.327.7414.557 10.1016/j.envres.2010.09.006 10.1002/ajim.20506 10.3945/an.117.015305 10.1289/ehp.1103548 10.1016/j.pnpbp.2017.07.011 10.3390/ijerph120606771 10.1016/j.toxlet.2011.08.008 10.1111/j.1365-2362.2010.02373.x 10.1016/j.neuro.2019.02.013 10.1016/j.neuro.2017.08.015 10.1289/EHP925 10.1111/jnc.14580 10.1016/j.envres.2017.12.003 10.1016/j.envres.2016.01.035 10.1016/j.envres.2014.10.003 10.1097/JOM.0b013e31821854da 10.1016/j.neuro.2009.05.001 10.1289/EHP631 10.1016/j.envres.2019.108562 10.1016/j.neuro.2017.07.024 10.1016/j.neuro.2012.01.005 10.1136/bmj.315.7109.629 10.1016/j.tox.2013.04.015 10.1016/j.envres.2015.09.003 10.1016/j.ijsu.2014.07.013 10.1016/j.neuro.2018.02.002 10.1007/s10393-015-1027-2 10.1016/j.neuro.2017.08.011 10.1038/celldisc.2017.25 10.1289/ehp.8030 10.1016/j.envint.2018.08.045 10.1289/ehp.1003397 10.1016/j.neuro.2011.07.010 10.1038/s41386-018-0111-z 10.1093/annweh/wxx091 10.1289/ehp.1509974 10.1016/j.ijheh.2014.09.002 10.1016/j.neuro.2011.05.007 |
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| DOI | 10.1186/s12940-020-00659-x |
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| References | PU Iyare (659_CR4) 2019; 73 S Nascimento (659_CR63) 2016; 147 EJ Ward (659_CR87) 2017; 62 M Egger (659_CR26) 1997; 315 W Laohaudomchok (659_CR94) 2011; 53 K Khan (659_CR71) 2012; 33 CC Lin (659_CR32) 2013; 123 CF Carvalho (659_CR46) 2018; 69 K Wahlberg (659_CR101) 2018; 64 JP Mahoney (659_CR79) 1968; 47 CR Robbins (659_CR81) 2002 Y Kim (659_CR58) 2009; 30 JL Madison (659_CR104) 2011; 32 MF Bouchard (659_CR8) 2018; 64 K Kordas (659_CR80) 2010; 408 A Mikó (659_CR18) 2018; 18 B Claus Henn (659_CR28) 2010; 21 EL Lucas (659_CR91) 2015; 138 S Yaemsiri (659_CR95) 2010; 24 M Meyer-Baron (659_CR11) 2009; 30 M Bouchard (659_CR45) 2007; 115 RO Wright (659_CR68) 2006; 27 S Frndak (659_CR51) 2019; 73 659_CR47 M Rodriguez-Barranco (659_CR10) 2013; 454–455 LA Dion (659_CR20) 2018; 64 RG Lucchini (659_CR61) 2019; 18 HH Sky-Peck (659_CR100) 1990; 8 Y Xin (659_CR74) 2017; 3 F Rugless (659_CR65) 2014; 41 EN Haynes (659_CR7) 2018; 64 JA Bauer (659_CR42) 2017; 108 SN do Nascimento (659_CR49) 2015; 136 DJ Coetzee (659_CR85) 2016; 15 B Claus Henn (659_CR37) 2018; 161 R Torres-Agustin (659_CR67) 2013; 121 R Ntihabose (659_CR92) 2018; 64 SM Rahman (659_CR69) 2017; 125 JP Higgins (659_CR25) 2003; 327 D Wechsler (659_CR23) 1991 GA Wasserman (659_CR19) 2016; 124 D Wang (659_CR93) 2008; 176 GF Kwakye (659_CR12) 2015; 12 EG Rodrigues (659_CR97) 2015; 25 M Torrente (659_CR66) 2005; 104 F Parvez (659_CR64) 2011; 119 SY Bhang (659_CR44) 2013; 126 K Khan (659_CR56) 2011; 119 GA Wasserman (659_CR72) 2011; 32 MK Horton (659_CR55) 2018; 121 M Arora (659_CR98) 2012; 46 T Zhou (659_CR39) 2019; 193 K Niedzielska (659_CR89) 1990; 43 RG Lucchini (659_CR60) 2012; 33 RB Gunier (659_CR31) 2015; 142 MJ Leonhard (659_CR3) 2019; 420 O Betancourt (659_CR43) 2015; 12 GA Wasserman (659_CR9) 2006; 114 XD Yu (659_CR35) 2014; 133 M Aschner (659_CR1) 2017; 8 JA Menezes-Filho (659_CR62) 2014; 45 W Zheng (659_CR90) 2011; 32 E von Elm (659_CR17) 2014; 12 H Riojas-Rodríguez (659_CR6) 2010; 118 G Liang (659_CR84) 2016; 23 JT Rogers (659_CR76) 2019; 20 MC Aprea (659_CR78) 2012; 210 B Claus Henn (659_CR29) 2017; 125 K Tuschl (659_CR73) 2016; 7 AM Mora (659_CR38) 2015; 84 D Hernandez-Bonilla (659_CR54) 2016; 57 EG Rodrigues (659_CR70) 2016; 15 M Yoon (659_CR99) 2009; 112 YM Chiu (659_CR48) 2017; 159 L Takser (659_CR34) 2003; 24 RR Eastman (659_CR86) 2013; 47 A Saghazadeh (659_CR5) 2017; 79 AN Kaczkurkin (659_CR102) 2019; 44 D Smith (659_CR88) 2007; 50 TC Ngun (659_CR103) 2011; 32 Z Xia (659_CR75) 2017; 13 JH Shih (659_CR14) 2018; 14 X Yu (659_CR36) 2016; 163 CF Carvalho (659_CR22) 2014; 45 E de Water (659_CR2) 2018; 64 V Venkataramani (659_CR77) 2018; 147 SM Rink (659_CR41) 2014; 69 SE Chung (659_CR27) 2015; 123 JA Menezes-Filho (659_CR21) 2011; 111 JE Ericson (659_CR50) 2007; 29 Y Oulhote (659_CR15) 2014; 122 C Freire (659_CR30) 2018; 621 K He (659_CR96) 2011; 41 EN Haynes (659_CR52) 2015; 123 M Arora (659_CR82) 2011; 409 D Hernandez-Bonilla (659_CR53) 2011; 32 RG Lucchini (659_CR59) 2012; 118 AM Mora (659_CR33) 2018; 126 I Al-Saleh (659_CR40) 2019; 176 WR Shadish (659_CR24) 1994 MF Bouchard (659_CR16) 2011; 119 M Kicinski (659_CR57) 2015; 218 S Llop (659_CR13) 2013; 311 S Hillson (659_CR83) 1996 |
| References_xml | – volume: 123 start-page: 52 year: 2013 ident: 659_CR32 publication-title: Environ Res doi: 10.1016/j.envres.2013.03.003 – volume: 133 start-page: 232 year: 2014 ident: 659_CR35 publication-title: Environ Res doi: 10.1016/j.envres.2014.04.012 – volume: 45 start-page: 293 year: 2014 ident: 659_CR62 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2013.09.006 – volume: 25 start-page: 639 issue: 6 year: 2015 ident: 659_CR97 publication-title: J Expo Sci Environ Epidemiol doi: 10.1038/jes.2015.45 – volume: 64 start-page: 94 year: 2018 ident: 659_CR7 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2017.09.001 – volume: 119 start-page: 138 issue: 1 year: 2011 ident: 659_CR16 publication-title: Environ Health Perspect doi: 10.1289/ehp.1002321 – volume: 47 start-page: 1629 issue: 3 year: 2013 ident: 659_CR86 publication-title: Environ Sci Technol. – volume: 29 start-page: 181 issue: 2 year: 2007 ident: 659_CR50 publication-title: Neurotoxicol Teratol doi: 10.1016/j.ntt.2006.09.020 – volume: 621 start-page: 340 year: 2018 ident: 659_CR30 publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2017.11.273 – volume-title: Dental anthropology year: 1996 ident: 659_CR83 doi: 10.1017/CBO9781139170697 – volume: 18 start-page: 67 issue: 1 year: 2019 ident: 659_CR61 publication-title: Environ Health doi: 10.1186/s12940-019-0505-3 – volume: 13 start-page: e1006892 issue: 7 year: 2017 ident: 659_CR75 publication-title: PLoS Genet doi: 10.1371/journal.pgen.1006892 – volume: 121 start-page: 39 year: 2013 ident: 659_CR67 publication-title: Environ Res doi: 10.1016/j.envres.2012.10.007 – volume: 32 start-page: 1 issue: 1 year: 2011 ident: 659_CR90 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2010.10.002 – volume: 122 start-page: 1343 issue: 12 year: 2014 ident: 659_CR15 publication-title: Environ Health Perspect doi: 10.1289/ehp.1307918 – volume: 32 start-page: 450 issue: 4 year: 2011 ident: 659_CR72 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2011.03.009 – volume: 193 start-page: 89 issue: 1 year: 2019 ident: 659_CR39 publication-title: Biol Trace Elem Res doi: 10.1007/s12011-019-01703-9 – volume: 46 start-page: 5118 issue: 9 year: 2012 ident: 659_CR98 publication-title: Environ Sci Technol doi: 10.1021/es203569f – volume: 24 start-page: 667 issue: 4–5 year: 2003 ident: 659_CR34 publication-title: Neurotoxicology doi: 10.1016/S0161-813X(03)00058-5 – volume: 32 start-page: 227 issue: 2 year: 2011 ident: 659_CR103 publication-title: Front Neuroendocrinol doi: 10.1016/j.yfrne.2010.10.001 – volume: 57 start-page: 230 year: 2016 ident: 659_CR54 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2016.10.006 – volume: 454–455 start-page: 562 year: 2013 ident: 659_CR10 publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2013.03.047 – volume: 138 start-page: 279 year: 2015 ident: 659_CR91 publication-title: Environ Res doi: 10.1016/j.envres.2015.01.019 – volume: 408 start-page: 4488 issue: 20 year: 2010 ident: 659_CR80 publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2010.06.041 – volume-title: Chemical and physical behavior of human hair year: 2002 ident: 659_CR81 doi: 10.1007/b97447 – volume: 163 start-page: 446 year: 2016 ident: 659_CR36 publication-title: Chemosphere doi: 10.1016/j.chemosphere.2016.07.095 – volume: 69 start-page: 46 issue: 1 year: 2014 ident: 659_CR41 publication-title: Arch Environ Occup Health doi: 10.1080/19338244.2012.725229 – volume: 420 start-page: 46 year: 2019 ident: 659_CR3 publication-title: Toxicology doi: 10.1016/j.tox.2019.03.004 – volume: 123 start-page: 717 issue: 7 year: 2015 ident: 659_CR27 publication-title: Environ Health Perspect doi: 10.1289/ehp.1307865 – volume: 41 start-page: 71 year: 2014 ident: 659_CR65 publication-title: Neurotoxicol Teratol doi: 10.1016/j.ntt.2013.12.005 – volume: 27 start-page: 210 issue: 2 year: 2006 ident: 659_CR68 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2005.10.001 – volume: 20 start-page: 994 issue: 4 year: 2019 ident: 659_CR76 publication-title: Int J Mol Sci doi: 10.3390/ijms20040994 – volume: 73 start-page: 188 year: 2019 ident: 659_CR51 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2019.04.004 – volume: 21 start-page: 433 issue: 4 year: 2010 ident: 659_CR28 publication-title: Epidemiology doi: 10.1097/EDE.0b013e3181df8e52 – volume: 47 start-page: 643 issue: 3 year: 1968 ident: 659_CR79 publication-title: J Clin Invest doi: 10.1172/JCI105760 – volume: 12 start-page: 7519 issue: 7 year: 2015 ident: 659_CR12 publication-title: Int J Env Res Pub He doi: 10.3390/ijerph120707519 – volume: 23 start-page: 12265 issue: 12 year: 2016 ident: 659_CR84 publication-title: Environ Sci Pollut Res Int doi: 10.1007/s11356-016-6420-z – volume: 24 start-page: 420 issue: 4 year: 2010 ident: 659_CR95 publication-title: J Eur Acad Dermatol Venereol doi: 10.1111/j.1468-3083.2009.03426.x – volume: 409 start-page: 1315 issue: 7 year: 2011 ident: 659_CR82 publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2010.12.018 – volume: 118 start-page: 1465 issue: 10 year: 2010 ident: 659_CR6 publication-title: Environ Health Perspect doi: 10.1289/ehp.0901229 – volume: 126 start-page: 057007 issue: 5 year: 2018 ident: 659_CR33 publication-title: Environ Health Perspect doi: 10.1289/EHP1955 – volume: 18 start-page: 107 issue: 1 year: 2018 ident: 659_CR18 publication-title: BMC Geriatr doi: 10.1186/s12877-018-0798-z – volume: 126 start-page: 9 year: 2013 ident: 659_CR44 publication-title: Environ Res doi: 10.1016/j.envres.2013.05.006 – volume: 159 start-page: 458 year: 2017 ident: 659_CR48 publication-title: Environ Res doi: 10.1016/j.envres.2017.08.035 – volume: 30 start-page: 564 issue: 4 year: 2009 ident: 659_CR58 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2009.03.012 – volume: 108 start-page: 299 year: 2017 ident: 659_CR42 publication-title: Environ Int doi: 10.1016/j.envint.2017.08.013 – volume: 123 start-page: 1066 issue: 10 year: 2015 ident: 659_CR52 publication-title: Environ Health Perspect doi: 10.1289/ehp.1408993 – volume: 14 start-page: 1831 year: 2018 ident: 659_CR14 publication-title: Neuropsychiatr Dis Treat doi: 10.2147/NDT.S165378 – volume: 64 start-page: 85 year: 2018 ident: 659_CR2 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2017.06.006 – volume: 84 start-page: 39 year: 2015 ident: 659_CR38 publication-title: Environ Int doi: 10.1016/j.envint.2015.07.009 – volume: 15 start-page: 44 year: 2016 ident: 659_CR70 publication-title: Environ Health doi: 10.1186/s12940-016-0127-y – volume: 104 start-page: 215 issue: 3 year: 2005 ident: 659_CR66 publication-title: Biol Trace Elem Res doi: 10.1385/BTER:104:3:215 – volume: 176 start-page: 40 issue: 1 year: 2008 ident: 659_CR93 publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2007.10.003 – volume: 64 start-page: 103 year: 2018 ident: 659_CR101 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2017.09.003 – volume: 118 start-page: 65 year: 2012 ident: 659_CR59 publication-title: Environ Res doi: 10.1016/j.envres.2012.08.003 – volume: 33 start-page: 91 issue: 1 year: 2012 ident: 659_CR71 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2011.12.002 – volume: 112 start-page: 44 issue: 1 year: 2009 ident: 659_CR99 publication-title: Toxicol Sci doi: 10.1093/toxsci/kfp198 – volume: 115 start-page: 122 issue: 1 year: 2007 ident: 659_CR45 publication-title: Environ Health Perspect doi: 10.1289/ehp.9504 – volume: 15 start-page: 91 issue: 1 year: 2016 ident: 659_CR85 publication-title: Environ Health doi: 10.1186/s12940-016-0174-4 – volume: 7 start-page: 11601 year: 2016 ident: 659_CR73 publication-title: Nat Commun doi: 10.1038/ncomms11601 – volume: 43 start-page: 316 issue: 6 year: 1990 ident: 659_CR89 publication-title: Czas Stomatol – volume: 45 start-page: 301 year: 2014 ident: 659_CR22 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2013.11.006 – volume: 327 start-page: 557 issue: 7414 year: 2003 ident: 659_CR25 publication-title: BMJ doi: 10.1136/bmj.327.7414.557 – volume: 111 start-page: 156 issue: 1 year: 2011 ident: 659_CR21 publication-title: Environ Res doi: 10.1016/j.envres.2010.09.006 – volume: 50 start-page: 801 issue: 11 year: 2007 ident: 659_CR88 publication-title: Am J Ind Med doi: 10.1002/ajim.20506 – volume: 8 start-page: 520 issue: 3 year: 2017 ident: 659_CR1 publication-title: Adv Nutr doi: 10.3945/an.117.015305 – volume-title: Wechsler intelligence scale for children year: 1991 ident: 659_CR23 – volume: 119 start-page: 1665 issue: 11 year: 2011 ident: 659_CR64 publication-title: Environ Health Perspect doi: 10.1289/ehp.1103548 – volume: 79 start-page: 340 issue: Pt B year: 2017 ident: 659_CR5 publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2017.07.011 – ident: 659_CR47 doi: 10.3390/ijerph120606771 – volume: 210 start-page: 110 issue: 2 year: 2012 ident: 659_CR78 publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2011.08.008 – volume: 41 start-page: 98 issue: 1 year: 2011 ident: 659_CR96 publication-title: Eur J Clin Investig doi: 10.1111/j.1365-2362.2010.02373.x – volume: 73 start-page: 1 year: 2019 ident: 659_CR4 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2019.02.013 – volume: 64 start-page: 118 year: 2018 ident: 659_CR20 publication-title: Neurotoxicology. doi: 10.1016/j.neuro.2017.08.015 – volume: 125 start-page: 067020 issue: 6 year: 2017 ident: 659_CR29 publication-title: Environ Health Perspect doi: 10.1289/EHP925 – volume: 147 start-page: 831 issue: 6 year: 2018 ident: 659_CR77 publication-title: J Neurochemistry doi: 10.1111/jnc.14580 – volume: 161 start-page: 588 year: 2018 ident: 659_CR37 publication-title: Environ Res doi: 10.1016/j.envres.2017.12.003 – start-page: 265 volume-title: The Handbook of Research Synthesis year: 1994 ident: 659_CR24 – volume: 147 start-page: 32 year: 2016 ident: 659_CR63 publication-title: Environ Res doi: 10.1016/j.envres.2016.01.035 – volume: 136 start-page: 387 year: 2015 ident: 659_CR49 publication-title: Environ Res doi: 10.1016/j.envres.2014.10.003 – volume: 53 start-page: 506 issue: 5 year: 2011 ident: 659_CR94 publication-title: J Occup Environ Med doi: 10.1097/JOM.0b013e31821854da – volume: 30 start-page: 487 issue: 4 year: 2009 ident: 659_CR11 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2009.05.001 – volume: 125 start-page: 057003 issue: 5 year: 2017 ident: 659_CR69 publication-title: Environ Health Perspect doi: 10.1289/EHP631 – volume: 176 start-page: 108562 year: 2019 ident: 659_CR40 publication-title: Environ Res doi: 10.1016/j.envres.2019.108562 – volume: 64 start-page: 110 year: 2018 ident: 659_CR8 publication-title: Neurotoxicology. doi: 10.1016/j.neuro.2017.07.024 – volume: 33 start-page: 687 issue: 4 year: 2012 ident: 659_CR60 publication-title: Neurotoxicology. doi: 10.1016/j.neuro.2012.01.005 – volume: 315 start-page: 629 issue: 7109 year: 1997 ident: 659_CR26 publication-title: BMJ doi: 10.1136/bmj.315.7109.629 – volume: 311 start-page: 3 issue: 1–2 year: 2013 ident: 659_CR13 publication-title: Toxicology doi: 10.1016/j.tox.2013.04.015 – volume: 142 start-page: 688 year: 2015 ident: 659_CR31 publication-title: Environ Res doi: 10.1016/j.envres.2015.09.003 – volume: 12 start-page: 1495 issue: 12 year: 2014 ident: 659_CR17 publication-title: Int J Surg doi: 10.1016/j.ijsu.2014.07.013 – volume: 69 start-page: 253 year: 2018 ident: 659_CR46 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2018.02.002 – volume: 12 start-page: 453 issue: 3 year: 2015 ident: 659_CR43 publication-title: Ecohealth doi: 10.1007/s10393-015-1027-2 – volume: 64 start-page: 126 year: 2018 ident: 659_CR92 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2017.08.011 – volume: 3 start-page: 17025 year: 2017 ident: 659_CR74 publication-title: Cell Discov doi: 10.1038/celldisc.2017.25 – volume: 114 start-page: 124 issue: 1 year: 2006 ident: 659_CR9 publication-title: Environ Health Perspect doi: 10.1289/ehp.8030 – volume: 8 start-page: 70 issue: 2 year: 1990 ident: 659_CR100 publication-title: Clin Physiol Biochem – volume: 121 start-page: 148 issue: Pt 1 year: 2018 ident: 659_CR55 publication-title: Environ Int doi: 10.1016/j.envint.2018.08.045 – volume: 119 start-page: 1501 issue: 10 year: 2011 ident: 659_CR56 publication-title: Environ Health Perspect doi: 10.1289/ehp.1003397 – volume: 32 start-page: 615 issue: 5 year: 2011 ident: 659_CR53 publication-title: Neurotoxicology. doi: 10.1016/j.neuro.2011.07.010 – volume: 44 start-page: 71 issue: 1 year: 2019 ident: 659_CR102 publication-title: Neuropsychopharmacology doi: 10.1038/s41386-018-0111-z – volume: 62 start-page: 101 issue: 1 year: 2017 ident: 659_CR87 publication-title: Ann Work Expos Heal doi: 10.1093/annweh/wxx091 – volume: 124 start-page: 1114 issue: 7 year: 2016 ident: 659_CR19 publication-title: Environ Health Perspect doi: 10.1289/ehp.1509974 – volume: 218 start-page: 139 issue: 1 year: 2015 ident: 659_CR57 publication-title: Int J Hyg Environ Health doi: 10.1016/j.ijheh.2014.09.002 – volume: 32 start-page: 896 issue: 6 year: 2011 ident: 659_CR104 publication-title: Neurotoxicology doi: 10.1016/j.neuro.2011.05.007 |
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Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results... Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been... Background Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results... Abstract Background Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the... |
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| SubjectTerms | Analysis Attention deficit hyperactivity disorder Behavior Biological markers Biomarker Biomarkers Biomarkers - analysis Child Child Development - drug effects Childhood Children Children's Environmental Health Cognition & reasoning Cognitive ability Cognitive function Confidence intervals Correlation analysis Cross-sectional studies Drinking behavior Drinking water Earth and Environmental Science Environment Environmental Exposure - adverse effects Environmental Health Environmental Pollutants - adverse effects Epidemiology Exposure Gender aspects Hair Hair - chemistry Humans Hyperactivity Intelligence Intelligence - drug effects Manganese Manganese - adverse effects Manganese exposure Meta-analysis Motor Motor skill Neurodevelopment Neurodevelopmental disorders Neurodevelopmental Disorders - chemically induced Occupational Medicine/Industrial Medicine Public Health Quotients Regression analysis Review Sex Sex differences Systematic review |
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| Title | Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis |
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