Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules

• Published in: EJNMMI research Vol. 12; no. 1; pp. 21 - 13
• Main Authors: Cicone, Francesco, Viertl, David, Denoël, Thibaut, Stabin, Michael G., Prior, John O., Gnesin, Silvano
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 11.04.2022; Springer Nature B.V; SpringerOpen
• Subjects: Activity coefficients; Algorithms; Allometric equations; Biodistribution; Cardiac Imaging; Comparative studies; Dose extrapolations; Dosimeters; Dosimetry; Extrapolation; Imaging; Laboratory animals; Macromolecules; Medicine; Medicine & Public Health; Metabolism; Mouse devices; Nuclear Medicine; Oncology; Organs; Original Research; Orthopedics; Parameters; Preclinical models; Radiology; Radiopharmaceuticals; Scaling; Scaling factor; Small animal dosimetry; Toxicity; Metabolic time scaling; Dose extrapolations; Small animal dosimetry; Scaling factor; Allometric equations; OLINDA/EXM® 2.0; Mass scaling; Radiopharmaceuticals; Preclinical models; Biodistribution

Background Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between available animal-to-human dosimetry extrapolation methods are missing. We compa...