Structure of a mammalian sperm cation channel complex

• Published in: Nature (London) Vol. 595; no. 7869; pp. 746 - 750
• Main Authors: Lin, Shiyi, Ke, Meng, Zhang, Yuqi, Yan, Zhen, Wu, Jianping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.07.2021; Nature Publishing Group
• Subjects: 101/28; 101/58; 45/23; 45/29; 45/77; 631/443/494; 631/535/1258/1259; 631/57/2283; 64/60; 82/16; 82/29; 82/83; Animals; Calcium Channels - chemistry; Cations; Cell research; Cells; Contraceptives; Cryoelectron Microscopy; Domains; Electron microscopy; Fertility; Health aspects; Humanities and Social Sciences; Infertility; Ion channels; Ion Channels - chemistry; Ions; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motility; multidisciplinary; Mutation; Physiological aspects; Physiology; Pore formation; Pore-forming proteins; Protein Structure, Quaternary; Proteins; Science; Science (multidisciplinary); Seminal Plasma Proteins - chemistry; Sperm; Sperm Motility; Spermatozoa; Structure; China

The cation channel of sperm (CatSper) is essential for sperm motility and fertility 1 , 2 . CatSper comprises the pore-forming proteins CATSPER1–4 and multiple auxiliary subunits, including CATSPERβ, γ, δ, ε, ζ, and EFCAB9 1 , 3 – 9 . Here we report the cryo-electron microscopy (cryo-EM) structure o...