Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury

• Published in: Nature communications Vol. 14; no. 1; pp. 8393 - 17
• Main Authors: Chu, Li-Kai, Cao, Xu, Wan, Lin, Diao, Qiang, Zhu, Yu, Kan, Yu, Ye, Li-Li, Mao, Yi-Ming, Dong, Xing-Qiang, Xiong, Qian-Wei, Fu, Ming-Cui, Zhang, Ting, Zhou, Hui-Ting, Cai, Shi-Zhong, Ma, Zhou-Rui, Hsu, Ssu-Wei, Wu, Reen, Chen, Ching-Hsien, Yan, Xiang-Ming, Liu, Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/2; 13/51; 13/89; 13/95; 14/19; 14/34; 49/109; 49/31; 49/88; 49/91; 631/337/458/582; 631/80/39/2346; 82/58; 82/83; Acute Kidney Injury; Apoptosis; Autophagy; Cell death; Clonal deletion; Degradation; Ferroptosis; Glutathione; Glutathione peroxidase; Humanities and Social Sciences; Humans; Hypoxia; Injuries; Ischemia; Kidney; Kidney diseases; Kidneys; multidisciplinary; Peroxidase; Renal function; Reperfusion; Reperfusion Injury; Science; Science (multidisciplinary); Spatial distribution; Transcriptomics

Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferroptosis and the molecular events causing GPX4 reduction during ischemia-reperfusion (I/R) r...