X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study
Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations. Methods Using X ch...
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| Published in | Respiratory research Vol. 24; no. 1; pp. 38 - 14 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
01.02.2023
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1465-993X 1465-9921 1465-993X |
| DOI | 10.1186/s12931-023-02337-1 |
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| Abstract | Background
The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations.
Methods
Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case–control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses.
Results
Among 10,193 subjects of non-Hispanic white or European ancestry, a variant near
TMSB4X,
rs5979771, reached genome-wide significance for association with lung function measured by FEV
1
/FVC (
β
0.020,
SE
0.004,
p
4.97 × 10
–08
), with suggestive evidence of association with FEV
1
(
β
0.092,
SE
0.018,
p
3.40 × 10
–07
). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions.
Conclusions
This investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology.
Trial registration
Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease. |
|---|---|
| AbstractList | The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations.BACKGROUNDThe association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations.Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case-control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses.METHODSUsing X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case-control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses.Among 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV1/FVC ([Formula: see text] 0.020, SE 0.004, p 4.97 × 10-08), with suggestive evidence of association with FEV1 ([Formula: see text] 0.092, SE 0.018, p 3.40 × 10-07). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions.RESULTSAmong 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV1/FVC ([Formula: see text] 0.020, SE 0.004, p 4.97 × 10-08), with suggestive evidence of association with FEV1 ([Formula: see text] 0.092, SE 0.018, p 3.40 × 10-07). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions.This investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology. Trial registration Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease.CONCLUSIONSThis investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology. Trial registration Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease. Abstract Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations. Methods Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case–control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses. Results Among 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV1/FVC ( $$\beta$$ β 0.020, SE 0.004, p 4.97 × 10–08), with suggestive evidence of association with FEV1 ( $$\beta$$ β 0.092, SE 0.018, p 3.40 × 10–07). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions. Conclusions This investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology. Trial registration Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease. Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations. Methods Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case–control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses. Results Among 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV 1 /FVC ( β 0.020, SE 0.004, p 4.97 × 10 –08 ), with suggestive evidence of association with FEV 1 ( β 0.092, SE 0.018, p 3.40 × 10 –07 ). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions. Conclusions This investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology. Trial registration Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease. Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations. Methods Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case-control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses. Results Among 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV.sub.1/FVC ([formula omitted] 0.020, SE 0.004, p 4.97 x 10.sup.-08), with suggestive evidence of association with FEV.sub.1 ([formula omitted] 0.092, SE 0.018, p 3.40 x 10.sup.-07). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions. Conclusions This investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology. Trial registration Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease. Keywords: COPD, Lung function, Emphysema, X chromosome-wide association study, Sex differences, X chromosome inactivation BackgroundThe association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations.MethodsUsing X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case–control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses.ResultsAmong 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV1/FVC (\(\beta\) 0.020, SE 0.004, p 4.97 × 10–08), with suggestive evidence of association with FEV1 (\(\beta\) 0.092, SE 0.018, p 3.40 × 10–07). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions.ConclusionsThis investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology.Trial registration Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease. The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations. Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case-control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses. Among 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV /FVC ([Formula: see text] 0.020, SE 0.004, p 4.97 × 10 ), with suggestive evidence of association with FEV ([Formula: see text] 0.092, SE 0.018, p 3.40 × 10 ). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions. This investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology. Trial registration Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease. The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations. Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case-control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses. Among 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV.sub.1/FVC ([formula omitted] 0.020, SE 0.004, p 4.97 x 10.sup.-08), with suggestive evidence of association with FEV.sub.1 ([formula omitted] 0.092, SE 0.018, p 3.40 x 10.sup.-07). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions. This investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology. |
| ArticleNumber | 38 |
| Audience | Academic |
| Author | Busch, Robert Liu, Ming Silverman, Edwin K. Lomas, David A. Bakke, Per Lopes-Ramos, Camila M. Laird, Nan M. Beaty, Terri H. Lange, Christoph DeMeo, Dawn L. Hayden, Lystra P. Crapo, James D. Gulsvik, Amund Hobbs, Brian D. Cho, Michael H. |
| Author_xml | – sequence: 1 givenname: Lystra P. surname: Hayden fullname: Hayden, Lystra P. organization: Division of Pulmonary Medicine, Boston Children’s Hospital, Harvard Medical School, Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School – sequence: 2 givenname: Brian D. surname: Hobbs fullname: Hobbs, Brian D. organization: Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School – sequence: 3 givenname: Robert surname: Busch fullname: Busch, Robert organization: Division of Pulmonology, Allergy, and Critical Care, U.S. Food and Drug Administration – sequence: 4 givenname: Michael H. surname: Cho fullname: Cho, Michael H. organization: Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School – sequence: 5 givenname: Ming surname: Liu fullname: Liu, Ming organization: Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute – sequence: 6 givenname: Camila M. surname: Lopes-Ramos fullname: Lopes-Ramos, Camila M. organization: Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Department of Biostatistics, Harvard T.H. Chan School of Public Health – sequence: 7 givenname: David A. surname: Lomas fullname: Lomas, David A. organization: UCL Respiratory, University College London – sequence: 8 givenname: Per surname: Bakke fullname: Bakke, Per organization: Department of Clinical Science, University of Bergen – sequence: 9 givenname: Amund surname: Gulsvik fullname: Gulsvik, Amund organization: Department of Clinical Science, University of Bergen – sequence: 10 givenname: Edwin K. surname: Silverman fullname: Silverman, Edwin K. organization: Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School – sequence: 11 givenname: James D. surname: Crapo fullname: Crapo, James D. organization: Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Health – sequence: 12 givenname: Terri H. surname: Beaty fullname: Beaty, Terri H. organization: Johns Hopkins School of Public Health – sequence: 13 givenname: Nan M. surname: Laird fullname: Laird, Nan M. organization: Department of Biostatistics, Harvard T.H. Chan School of Public Health – sequence: 14 givenname: Christoph surname: Lange fullname: Lange, Christoph organization: Department of Biostatistics, Harvard T.H. Chan School of Public Health – sequence: 15 givenname: Dawn L. surname: DeMeo fullname: DeMeo, Dawn L. email: dawn.demeo@channing.harvard.edu organization: Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36726148$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jaci_2024_08_013 crossref_primary_10_1016_S1877_1203_24_00050_8 crossref_primary_10_1038_s41598_025_89020_1 |
| Cites_doi | 10.1093/biostatistics/kxn007 10.1165/rcmb.2016-0172OC 10.1016/S0021-9258(19)61505-X 10.1002/gepi.21782 10.1164/ajrccm.162.3.9907120 10.1038/ng.2293 10.1002/gepi.20616 10.1016/j.ajhg.2019.02.022 10.3109/15412550903499522 10.1038/ng.381 10.1183/13993003.00996-2015 10.1038/nature24265 10.1080/14712598.2018.1473854 10.3389/fcell.2019.00241 10.1002/gepi.21979 10.1073/pnas.96.25.14180 10.1016/j.ajhg.2013.03.017 10.1038/s41467-018-05369-0 10.1038/s41467-020-18334-7 10.1016/bs.ai.2019.04.001 10.1038/ncomms9658 10.1371/journal.pgen.1000421 10.1164/rccm.201011-1928OC 10.1038/ng.535 10.1074/jbc.M113.463315 10.1093/molbev/mst148 10.1186/s12864-019-5507-6 10.1038/s41588-018-0342-2 10.1164/rccm.201701-0218PP 10.1093/nar/gkv1290 10.1371/journal.pone.0113684 10.1016/j.tig.2016.03.007 10.3390/medicina55050187 10.1371/journal.pgen.1003500 10.1517/14712598.2015.1026804 10.1038/s41591-022-01891-3 10.1183/13993003.02108-2020 10.1155/2015/206937 10.1186/1465-9921-12-22 10.1038/nature03479 10.1016/j.celrep.2020.107795 10.1038/ng.2653 10.1530/ey.18.14.14 10.1186/s13742-015-0047-8 10.1016/S2213-2600(20)30101-6 10.1093/bioinformatics/btv402 10.1038/s41588-018-0321-7 10.1002/gepi.21814 10.1186/gb-2013-14-11-r122 10.1038/ejhg.2016.197 10.1183/09031936.00111707 10.1038/ng1847 10.3389/fcell.2021.693154 |
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| DOI | 10.1186/s12931-023-02337-1 |
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| Keywords | Sex differences Lung function Emphysema X chromosome-wide association study X chromosome inactivation COPD |
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| License | 2023. The Author(s). Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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| References | P Sakornsakolpat (2337_CR3) 2019; 51 S Choi (2337_CR52) 2016; 40 JE Kugler (2337_CR44) 2013; 288 BP Balaton (2337_CR46) 2016; 32 C Taggart (2337_CR38) 2000; 275 IR Konig (2337_CR5) 2014; 38 MJ Machiela (2337_CR43) 2015; 31 AL Wise (2337_CR8) 2013; 92 C Tcheandjieu (2337_CR18) 2022; 28 JM Leung (2337_CR30) 2020; 56 NCBI Resource Coordinators (2337_CR32) 2016; 44 T Tukiainen (2337_CR34) 2017; 550 Y Zhang (2337_CR49) 2013; 30 J Vestbo (2337_CR20) 2008; 31 L Carrel (2337_CR47) 2005; 434 PF Hickey (2337_CR7) 2011; 35 MG Foreman (2337_CR9) 2011; 184 CR Marques (2337_CR12) 2017; 25 D Chang (2337_CR13) 2014; 9 JC Randall (2337_CR28) 2013; 9 BJ Posynick (2337_CR51) 2019; 7 Consortium GT (2337_CR33) 2013; 45 E Conte (2337_CR39) 2015; 15 AL Price (2337_CR26) 2006; 38 I Naciri (2337_CR54) 2021; 9 M Moll (2337_CR2) 2020; 8 M Soler Artigas (2337_CR14) 2015; 6 MH Cho (2337_CR24) 2010; 42 J Wang (2337_CR27) 2014; 38 OM Yaman (2337_CR40) 2019; 55 LP Hayden (2337_CR19) 2019; 199 CM Disteche (2337_CR48) 1999; 96 EA Regan (2337_CR1) 2010; 7 JC Barrett (2337_CR55) 2009; 41 CM Lopes-Ramos (2337_CR53) 2020; 31 M Hardin (2337_CR4) 2017; 56 WJ Kim (2337_CR36) 2015; 2015 MG Dunlop (2337_CR56) 2012; 44 CC Chang (2337_CR25) 2015; 4 AB Wyss (2337_CR15) 2018; 9 N Shrine (2337_CR16) 2019; 51 CF Vogelmeier (2337_CR22) 2017; 195 D Clayton (2337_CR6) 2008; 9 S Aryal (2337_CR10) 2014; 9 G Renga (2337_CR41) 2018; 18 M Hardin (2337_CR11) 2016; 47 2337_CR35 MAR Ferreira (2337_CR42) 2019; 104 S Laffont (2337_CR45) 2019; 142 X Zhao (2337_CR17) 2020; 11 SG Pillai (2337_CR21) 2009; 5 M De Santis (2337_CR37) 2011; 12 Y Nakano (2337_CR23) 2000; 162 T Takahashi (2337_CR29) 2020; 139 K Wainer Katsir (2337_CR50) 2019; 20 AM Cotton (2337_CR31) 2013; 14 |
| References_xml | – volume: 9 start-page: 593 issue: 4 year: 2008 ident: 2337_CR6 publication-title: Biostatistics doi: 10.1093/biostatistics/kxn007 – volume: 199 start-page: A4868 year: 2019 ident: 2337_CR19 publication-title: Am J Respir Crit Care Med – volume: 56 start-page: 332 issue: 3 year: 2017 ident: 2337_CR4 publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2016-0172OC – volume: 9 start-page: 1145 year: 2014 ident: 2337_CR10 publication-title: Int J Chron Obstruct Pulmon Dis – volume: 275 start-page: 27258 issue: 35 year: 2000 ident: 2337_CR38 publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)61505-X – volume: 38 start-page: 97 issue: 2 year: 2014 ident: 2337_CR5 publication-title: Genet Epidemiol doi: 10.1002/gepi.21782 – volume: 139 start-page: 788 year: 2020 ident: 2337_CR29 publication-title: Nature – volume: 162 start-page: 1102 issue: 3 Pt 1 year: 2000 ident: 2337_CR23 publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.162.3.9907120 – volume: 44 start-page: 770 issue: 7 year: 2012 ident: 2337_CR56 publication-title: Nat Genet doi: 10.1038/ng.2293 – volume: 35 start-page: 664 issue: 7 year: 2011 ident: 2337_CR7 publication-title: Genet Epidemiol doi: 10.1002/gepi.20616 – volume: 104 start-page: 665 issue: 4 year: 2019 ident: 2337_CR42 publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2019.02.022 – volume: 7 start-page: 32 issue: 1 year: 2010 ident: 2337_CR1 publication-title: COPD doi: 10.3109/15412550903499522 – volume: 41 start-page: 703 issue: 6 year: 2009 ident: 2337_CR55 publication-title: Nat Genet doi: 10.1038/ng.381 – volume: 47 start-page: 104 issue: 1 year: 2016 ident: 2337_CR11 publication-title: Eur Respir J doi: 10.1183/13993003.00996-2015 – volume: 550 start-page: 244 issue: 7675 year: 2017 ident: 2337_CR34 publication-title: Nature doi: 10.1038/nature24265 – volume: 18 start-page: 171 issue: sup1 year: 2018 ident: 2337_CR41 publication-title: Expert Opin Biol Ther doi: 10.1080/14712598.2018.1473854 – volume: 7 start-page: 241 year: 2019 ident: 2337_CR51 publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2019.00241 – volume: 40 start-page: 475 issue: 6 year: 2016 ident: 2337_CR52 publication-title: Genet Epidemiol doi: 10.1002/gepi.21979 – volume: 96 start-page: 14180 issue: 25 year: 1999 ident: 2337_CR48 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.96.25.14180 – volume: 92 start-page: 643 issue: 5 year: 2013 ident: 2337_CR8 publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2013.03.017 – volume: 9 start-page: 2976 issue: 1 year: 2018 ident: 2337_CR15 publication-title: Nat Commun doi: 10.1038/s41467-018-05369-0 – volume: 11 start-page: 5182 issue: 1 year: 2020 ident: 2337_CR17 publication-title: Nat Commun doi: 10.1038/s41467-020-18334-7 – volume: 142 start-page: 35 year: 2019 ident: 2337_CR45 publication-title: Adv Immunol doi: 10.1016/bs.ai.2019.04.001 – volume: 6 start-page: 8658 year: 2015 ident: 2337_CR14 publication-title: Nat Commun doi: 10.1038/ncomms9658 – volume: 5 issue: 3 year: 2009 ident: 2337_CR21 publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000421 – volume: 184 start-page: 414 issue: 4 year: 2011 ident: 2337_CR9 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201011-1928OC – volume: 42 start-page: 200 issue: 3 year: 2010 ident: 2337_CR24 publication-title: Nat Genet doi: 10.1038/ng.535 – volume: 288 start-page: 16690 issue: 23 year: 2013 ident: 2337_CR44 publication-title: J Biol Chem doi: 10.1074/jbc.M113.463315 – volume: 30 start-page: 2588 issue: 12 year: 2013 ident: 2337_CR49 publication-title: Mol Biol Evol doi: 10.1093/molbev/mst148 – volume: 20 start-page: 201 issue: 1 year: 2019 ident: 2337_CR50 publication-title: BMC Genomics doi: 10.1186/s12864-019-5507-6 – volume: 51 start-page: 494 issue: 3 year: 2019 ident: 2337_CR3 publication-title: Nat Genet doi: 10.1038/s41588-018-0342-2 – volume: 195 start-page: 557 issue: 5 year: 2017 ident: 2337_CR22 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201701-0218PP – volume: 44 start-page: D7 issue: D1 year: 2016 ident: 2337_CR32 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkv1290 – volume: 9 issue: 12 year: 2014 ident: 2337_CR13 publication-title: PLoS ONE doi: 10.1371/journal.pone.0113684 – volume: 32 start-page: 348 issue: 6 year: 2016 ident: 2337_CR46 publication-title: Trends Genet doi: 10.1016/j.tig.2016.03.007 – volume: 55 start-page: 187 issue: 5 year: 2019 ident: 2337_CR40 publication-title: Medicina (Kaunas) doi: 10.3390/medicina55050187 – volume: 9 issue: 6 year: 2013 ident: 2337_CR28 publication-title: PLoS Genet doi: 10.1371/journal.pgen.1003500 – volume: 15 start-page: S211 issue: Suppl 1 year: 2015 ident: 2337_CR39 publication-title: Expert Opin Biol Ther doi: 10.1517/14712598.2015.1026804 – volume: 28 start-page: 1679 issue: 8 year: 2022 ident: 2337_CR18 publication-title: Nat Med doi: 10.1038/s41591-022-01891-3 – volume: 56 start-page: 2002108 issue: 2 year: 2020 ident: 2337_CR30 publication-title: Eur Respir J doi: 10.1183/13993003.02108-2020 – volume: 2015 year: 2015 ident: 2337_CR36 publication-title: Int J Genomics doi: 10.1155/2015/206937 – volume: 12 start-page: 22 year: 2011 ident: 2337_CR37 publication-title: Respir Res doi: 10.1186/1465-9921-12-22 – volume: 434 start-page: 400 issue: 7031 year: 2005 ident: 2337_CR47 publication-title: Nature doi: 10.1038/nature03479 – volume: 31 issue: 12 year: 2020 ident: 2337_CR53 publication-title: Cell Rep doi: 10.1016/j.celrep.2020.107795 – volume: 45 start-page: 580 issue: 6 year: 2013 ident: 2337_CR33 publication-title: Nat Genet doi: 10.1038/ng.2653 – ident: 2337_CR35 doi: 10.1530/ey.18.14.14 – volume: 4 start-page: 7 year: 2015 ident: 2337_CR25 publication-title: Gigascience doi: 10.1186/s13742-015-0047-8 – volume: 8 start-page: 696 issue: 7 year: 2020 ident: 2337_CR2 publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(20)30101-6 – volume: 31 start-page: 3555 issue: 21 year: 2015 ident: 2337_CR43 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv402 – volume: 51 start-page: 481 issue: 3 year: 2019 ident: 2337_CR16 publication-title: Nat Genet doi: 10.1038/s41588-018-0321-7 – volume: 38 start-page: 483 issue: 6 year: 2014 ident: 2337_CR27 publication-title: Genet Epidemiol doi: 10.1002/gepi.21814 – volume: 14 start-page: R122 issue: 11 year: 2013 ident: 2337_CR31 publication-title: Genome Biol doi: 10.1186/gb-2013-14-11-r122 – volume: 25 start-page: 439 issue: 4 year: 2017 ident: 2337_CR12 publication-title: Eur J Hum Genet doi: 10.1038/ejhg.2016.197 – volume: 31 start-page: 869 issue: 4 year: 2008 ident: 2337_CR20 publication-title: Eur Respir J doi: 10.1183/09031936.00111707 – volume: 38 start-page: 904 issue: 8 year: 2006 ident: 2337_CR26 publication-title: Nat Genet doi: 10.1038/ng1847 – volume: 9 year: 2021 ident: 2337_CR54 publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2021.693154 |
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The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome... The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants... Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome... BackgroundThe association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome... Abstract Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X... |
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| SubjectTerms | Analysis Care and treatment Chromosomes Chronic obstructive pulmonary disease COPD Datasets Diagnosis Emphysema Epidemiology Female Females Gender differences Gene loci Genetic analysis Genetic aspects Genetic control Genetic diversity Genetic markers Genetic Predisposition to Disease - genetics Genetic variance Genetics Genome-Wide Association Study Genomes Health aspects Humans Inactivation Interrogation Lung diseases Lung diseases, Obstructive Lung function Male Males Medicine Medicine & Public Health Obstructive lung disease Phenotype Phenotypes Pneumology/Respiratory System Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Emphysema Quality control Regression analysis Respiratory function Sex differences Smokers Smoking Software Spirometry X Chromosome X chromosome inactivation X chromosome-wide association study X chromosomes |
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| Title | X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study |
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