Diagnostic accuracy assessment of molecular prediction model for the risk of NAFLD based on MRI-PDFF diagnosed Chinese Han population

• Published in: BMC gastroenterology Vol. 21; no. 1; pp. 88 - 7
• Main Authors: Zhang, Qing, Zhu, Yueli, Yu, Wanjiang, Xu, Zhipeng, Zhao, Zhenzhen, Liu, Shousheng, Xin, Yongning, Lv, Kuirong
• Format: Journal Article
• Language: English
• Published: London BioMed Central 25.02.2021; BioMed Central Ltd; BMC
• Subjects: Accuracy; Age; Biopsy; Blood pressure; Body mass index; China; Diabetes; Diagnosis; Evaluation; Fatty liver; Gastroenterology; Hepatitis; Hepatobiliary and pancreatic disorders; Hepatology; Humans; Internal Medicine; Liver - diagnostic imaging; Liver diseases; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Metabolic syndrome; Molecular diagnostic techniques; Molecular modelling; Molecular prediction model; MRI-PDFF; Non-alcoholic fatty liver disease; Non-alcoholic Fatty Liver Disease - diagnostic imaging; Prediction models; Research Article; ROC Curve; Software; Statistical analysis; Steatosis; Ultrasonic imaging; China; Non-alcoholic fatty liver disease; Molecular prediction model; MRI-PDFF
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-021-01675-y

Background Several molecular prediction models based on the clinical parameters had been constructed to predict and diagnosis the risk of NAFLD, but the accuracy of these molecular prediction models remains need to be verified based on the most accurate NAFLD diagnostic method. The aim of this study was to verify the accuracy of three molecular prediction models Fatty liver index (FLI), NAFLD liver fat score system (NAFLD LFS), and Liver fat (%) in the prediction and diagnosis of NAFLD in MRI-PDFF diagnosed Chinese Han population. Patients and methods MRI-PDFF was used to diagnose the hepatic steatosis of all the subjects. Information such as name, age, lifestyle, and major medical histories were collected and the clinical parameters were measured by the standard clinical laboratory techniques. The cut-off values of each model for the risk of NAFLD were calculated based on the MRI-PDFF results. All data were analyzed using the statistical analysis software SPSS 23.0. Results A total of 169 subjects were recruited with the matched sex and age. The ROC curves of FLI, NAFLD LFS, and Liver fat (%) models were plotted based on the results of MRI-PDFF. We founded that the accuracy of FLI, NAFLD LFS, and Liver fat (%) models for the prediction and diagnosis of NAFLD were comparative available in Chinese Han population as well as the validity of them in other ethnics and regions. Conclusions The molecular prediction models FLI, NAFLD LFS, and Liver fat (%) were comparative available for the prediction and diagnosis of NAFLD in Chinese Han population. MRI-PDFF could be used as the golden standard to develop the new molecular prediction models for the prediction and diagnosis of NAFLD.