In silico structural, phylogenetic and drug target analysis of putrescine monooxygenase from Shewanella putrefaciens-95

• Published in: Journal of Genetic Engineering and Biotechnology Vol. 20; no. 1; pp. 57 - 14
• Main Authors: Shyam Mohan, Anil H., Rao, Saroja Narsing, D., Srividya, Rajeswari, N.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 12.04.2022; Springer; Springer Nature B.V; Elsevier
• Subjects: Affinity; Amino acids; Analysis; Antibiotics; Bacteria; Binding; Biomedical Engineering and Bioengineering; Conserved sequence; Curcumin; E coli; Engineering; Enzymes; Escherichia coli; Flavin-adenine dinucleotide; Immunity; Inhibitors; Iodine; Maximum likelihood method; Metal oxide semiconductors; Microorganisms; Molecular docking; Monooxygenase; N-Hydroxylating monooxygenases; Naturally occurring inhibitors; Nucleotide sequence; Nutrients; Phylogenetic relationship; Phylogenetics; Phylogeny; Physicochemical characteristics; Physicochemical properties; Polyamines; Protein structure; Proteins; Putrescine; Secondary structure; Shewanella putrefaciens; Software; Substrate preferences; Substrate specificity; Substrates; Therapeutic targets; Three dimensional models; Trace elements; Tuberculosis; Whooping cough; India; Phylogenetic relationship; Naturally occurring inhibitors; Physicochemical characteristics; N-Hydroxylating monooxygenases; Molecular docking; Shewanella putrefaciens

Background The enormous and irresponsible use of antibiotics has led to the emergence of resistant strains of bacteria globally. A new approach to combat this crisis has been nutritional immunity limiting the availability of nutrients to pathogens. Targeting the siderophore biosynthetic pathway that...