Attenuated activation of pulmonary immune cells in mRNA-1273–vaccinated hamsters after SARS-CoV-2 infection

• Published in: The Journal of clinical investigation Vol. 131; no. 20; pp. 1 - 16
• Main Authors: Meyer, Michelle, Wang, Yuan, Edwards, Darin, Smith, Gregory R., Rubenstein, Aliza B., Ramanathan, Palaniappan, Mire, Chad E., Pietzsch, Colette, Chen, Xi, Ge, Yongchao, Cheng, Wan Sze, Henry, Carole, Woods, Angela, Ma, LingZhi, Stewart-Jones, Guillaume B.E., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Periasamy, Sivakumar, Shi, Pei-Yong, Graham, Barney S., Moore, Ian N., Ramos, Irene, Troyanskaya, Olga G., Zaslavsky, Elena, Carfi, Andrea, Sealfon, Stuart C., Bukreyev, Alexander
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 15.10.2021
• Subjects: 2019-nCoV Vaccine mRNA-1273; Animals; Antibodies; Antibodies, Neutralizing - biosynthesis; Antibodies, Viral - biosynthesis; Antiviral drugs; Biomedical research; Cell activation; Coronaviruses; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; COVID-19 Vaccines - pharmacology; Development and progression; Disease Models, Animal; Disease transmission; FDA approval; Female; Hamsters; Health aspects; Homeostasis; Humans; Immune response; Immunization, Secondary; Immunological research; Infections; Inflammation; Leukocytes; Lung - immunology; Lung - pathology; Lung - virology; Lung diseases; Lungs; Lymphocyte Activation; Lymphocytes; Mesocricetus; Messenger RNA; Physiological aspects; Prevention; Replication; SARS-CoV-2 - immunology; SARS-CoV-2 - physiology; Severe acute respiratory syndrome coronavirus 2; Single-Cell Analysis; Transcriptomes; Vaccines; Virus Replication; United States; Adaptive immunity; Immunology; Vaccines; Bioinformatics; Cellular immune response

The mRNA-1273 vaccine is effective against SARS-CoV-2 and was granted emergency use authorization by the FDA. Clinical studies, however, cannot provide the controlled response to infection and complex immunological insight that are only possible with preclinical studies. Hamsters are the only model...