G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis

• Published in: Nature communications Vol. 15; no. 1; pp. 1045 - 17
• Main Authors: Wang, Wenmeng, Li, Dangdang, Xu, Qingqing, Cheng, Jiahui, Yu, Zhiwei, Li, Guangyue, Qiao, Shiyao, Pan, Jiasong, Wang, Hao, Shi, Jinming, Zheng, Tongsen, Sui, Guangchao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 14/19; 14/35; 38/109; 45/15; 59; 631/337/572/2102; 631/57/2269; 631/67/395; 64/60; 82/29; 82/83; 96; Binding; Bromodomain Containing Proteins; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell proliferation; Condensates; Cyclin D1 - genetics; Cyclin D1 - metabolism; DNA-Binding Proteins - metabolism; DNA-directed RNA polymerase; G-Quadruplexes; Gene expression; Hepatocellular carcinoma; Histones; Humanities and Social Sciences; Humans; Liver cancer; Motility; multidisciplinary; Nuclear Proteins - metabolism; Phase separation; RNA polymerase; RNA polymerase II; Science; Science (multidisciplinary); Transcription factors; Transcription Factors - metabolism; Xenotransplantation; Zinc finger proteins; Zinc Fingers - genetics

G-quadruplexes (G4s) can recruit transcription factors to activate gene expression, but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 promoter propel the motility in MAZ phase-separated condensates and subsequently activate CCND1 transcription. Zinc finger (ZF) 2 o...