Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestine

• Published in: BMC veterinary research Vol. 52; no. 1; p. 86
• Main Authors: Duan, Cong, Wang, Junchi, Liu, Yi, Zhang, Jialu, Si, Jianyong, Hao, Zhihui, Wang, Jiufeng
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 14.06.2021; BioMed Central; BMC
• Subjects: Analysis; animal models; Antiviral; Antiviral agents; Antiviral drugs; Apoptosis; Blood; Chromatography; Coronaviruses; Cryptoporus volvatus; cytokines; Diarrhea; enteropathogens; Epidemics; ergosterol; Ergosterol peroxide; Ethanol; Feces; Hogs; Immunomodulators; Immunomodulatory; Infection; Infections; Inflammation; Intestinal barrier; Kinases; Life Sciences; Lymphocytes; mushrooms; Oral administration; Pathogenesis; Pathogens; Phytosterols; Plant lipids; Porcine deltacoronavirus; Porcine deltacoronaviruses; Proteins; Signal transduction; Small intestine; Swine; tight junctions; veterinary medicine; Viral infections; viral load; Viruses; China; Germany; United States > US; Japan; Intestinal barrier; Antiviral; Immunomodulatory; Ergosterol peroxide; Porcine deltacoronavirus

Porcine deltacoronavirus (PDCoV) is a newly discovered swine enteropathogenic coronavirus with worldwide distribution. However, efficient strategies to prevent or treat the infection remain elusive. Our in vitro study revealed that ergosterol peroxide (EP) from the mushroom Cryptoporus volvatus has...