Effect of probiotics on obesity-related markers per enterotype: a double-blind, placebo-controlled, randomized clinical trial
Background Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this...
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| Published in | The EPMA journal Vol. 11; no. 1; pp. 31 - 51 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cham
Springer International Publishing
01.03.2020
BioMed Central Ltd Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1878-5077 1878-5085 |
| DOI | 10.1007/s13167-020-00198-y |
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| Abstract | Background
Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype.
Methods
Fifty subjects with body mass index over 25 kg/m
2
were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis.
Results
Gut microbial compositions of all the subjects were classified into two enterotypes according to
Prevotella
/
Bacteroides
ratio. The fat percentage, blood glucose, and insulin significantly increased in the
Prevotella
-rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, visceral fat, and ratio of visceral to subcutaneous fat area, were significantly reduced in the probiotic group. The decrease of obesity-related markers was greater in the
Prevotella
-rich enterotype than in the
Bacteroides
-rich enterotype.
Conclusion
Administration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in the
Prevotella
-dominant enterotype. |
|---|---|
| AbstractList | Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype.BACKGROUNDPrevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype.Fifty subjects with body mass index over 25 kg/m2 were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis.METHODSFifty subjects with body mass index over 25 kg/m2 were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis.Gut microbial compositions of all the subjects were classified into two enterotypes according to Prevotella/Bacteroides ratio. The fat percentage, blood glucose, and insulin significantly increased in the Prevotella-rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, visceral fat, and ratio of visceral to subcutaneous fat area, were significantly reduced in the probiotic group. The decrease of obesity-related markers was greater in the Prevotella-rich enterotype than in the Bacteroides-rich enterotype.RESULTSGut microbial compositions of all the subjects were classified into two enterotypes according to Prevotella/Bacteroides ratio. The fat percentage, blood glucose, and insulin significantly increased in the Prevotella-rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, visceral fat, and ratio of visceral to subcutaneous fat area, were significantly reduced in the probiotic group. The decrease of obesity-related markers was greater in the Prevotella-rich enterotype than in the Bacteroides-rich enterotype.Administration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in the Prevotella-dominant enterotype.CONCLUSIONAdministration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in the Prevotella-dominant enterotype. Background Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype. Methods Fifty subjects with body mass index over 25 kg/m 2 were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis. Results Gut microbial compositions of all the subjects were classified into two enterotypes according to Prevotella / Bacteroides ratio. The fat percentage, blood glucose, and insulin significantly increased in the Prevotella -rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, visceral fat, and ratio of visceral to subcutaneous fat area, were significantly reduced in the probiotic group. The decrease of obesity-related markers was greater in the Prevotella -rich enterotype than in the Bacteroides -rich enterotype. Conclusion Administration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in the Prevotella -dominant enterotype. Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype. Fifty subjects with body mass index over 25 kg/m were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis. Gut microbial compositions of all the subjects were classified into two enterotypes according to / ratio. The fat percentage, blood glucose, and insulin significantly increased in the -rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, visceral fat, and ratio of visceral to subcutaneous fat area, were significantly reduced in the probiotic group. The decrease of obesity-related markers was greater in the -rich enterotype than in the -rich enterotype. Administration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in the -dominant enterotype. BackgroundPrevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype.MethodsFifty subjects with body mass index over 25 kg/m2 were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis.ResultsGut microbial compositions of all the subjects were classified into two enterotypes according to Prevotella/Bacteroides ratio. The fat percentage, blood glucose, and insulin significantly increased in the Prevotella-rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, visceral fat, and ratio of visceral to subcutaneous fat area, were significantly reduced in the probiotic group. The decrease of obesity-related markers was greater in the Prevotella-rich enterotype than in the Bacteroides-rich enterotype.ConclusionAdministration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in the Prevotella-dominant enterotype. Background Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype. Methods Fifty subjects with body mass index over 25 kg/m.sup.2 were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis. Results Gut microbial compositions of all the subjects were classified into two enterotypes according to Prevotella/Bacteroides ratio. The fat percentage, blood glucose, and insulin significantly increased in the Prevotella-rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, visceral fat, and ratio of visceral to subcutaneous fat area, were significantly reduced in the probiotic group. The decrease of obesity-related markers was greater in the Prevotella-rich enterotype than in the Bacteroides-rich enterotype. Conclusion Administration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in the Prevotella-dominant enterotype. Keywords: Predictive preventive personalized medicine, Probiotics, Obesity, Clinical trial, Gut microbial enterotype Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut microbiota has different community structures. Because gut microbial composition is assumed to be linked to probiotic function, this study evaluated the efficacy of probiotics on obesity-related clinical markers according to gut microbial enterotype. Fifty subjects with body mass index over 25 kg/m.sup.2 were randomly assigned to either the probiotic or placebo group. Each group received either unlabeled placebo or probiotic capsules for 12 weeks. Body weight, waist circumference, and body composition were measured every 3 weeks. Using computed tomography, total abdominal fat area and visceral fat area were measured. Blood and fecal samples were collected before and after the intervention for biochemical parameters and gut microbial compositions analysis. Gut microbial compositions of all the subjects were classified into two enterotypes according to Prevotella/Bacteroides ratio. The fat percentage, blood glucose, and insulin significantly increased in the Prevotella-rich enterotype of the placebo group. The obesity-related markers, such as waist circumference, total fat area, visceral fat, and ratio of visceral to subcutaneous fat area, were significantly reduced in the probiotic group. The decrease of obesity-related markers was greater in the Prevotella-rich enterotype than in the Bacteroides-rich enterotype. Administration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in the Prevotella-dominant enterotype. |
| Audience | Professional Academic |
| Author | Song, Eun-Ji Kim, Hojun Nam, Young-Do Lim, Tae-Joong Chung, Myung-Jun Lim, Sanghyun Nam, Myung Hee Han, Kyungsun |
| Author_xml | – sequence: 1 givenname: Eun-Ji surname: Song fullname: Song, Eun-Ji organization: Research Group of Healthcare, Korea Food Research Institute, Department of Food Biotechnology, Korea University of Science and Technology – sequence: 2 givenname: Kyungsun surname: Han fullname: Han, Kyungsun organization: Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, Clinical Medicine Division, Korea Institute of Oriental Medicine – sequence: 3 givenname: Tae-Joong surname: Lim fullname: Lim, Tae-Joong organization: Research and Development Center, Cell Biotech Co. Ltd – sequence: 4 givenname: Sanghyun surname: Lim fullname: Lim, Sanghyun organization: Research and Development Center, Cell Biotech Co. Ltd – sequence: 5 givenname: Myung-Jun surname: Chung fullname: Chung, Myung-Jun organization: Research and Development Center, Cell Biotech Co. Ltd – sequence: 6 givenname: Myung Hee surname: Nam fullname: Nam, Myung Hee organization: Environmental Risk and Welfare Research Team, Korea Basic Science Institute – sequence: 7 givenname: Hojun surname: Kim fullname: Kim, Hojun email: kimklar@dongguk.ac.kr organization: Department of Rehabilitation Medicine of Korean Medicine, Dongguk University – sequence: 8 givenname: Young-Do orcidid: 0000-0002-2660-3569 surname: Nam fullname: Nam, Young-Do email: youngdo98@kfri.re.kr organization: Research Group of Healthcare, Korea Food Research Institute, Department of Food Biotechnology, Korea University of Science and Technology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32140184$$D View this record in MEDLINE/PubMed |
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| Copyright | European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2020 European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2020. COPYRIGHT 2020 BioMed Central Ltd. 2020© European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2020 |
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Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity.... Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity. Human gut... Background Prevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity.... BackgroundPrevention and improvement of disease symptoms are important issues, and probiotics are suggested as a good treatment for controlling the obesity.... |
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| SubjectTerms | Biomedical and Life Sciences Biomedicine Blood glucose Body mass index Body weight CAT scans Clinical trials Diseases Double-blind studies Glucose Health risk assessment Insulin Medicine/Public Health Microbiota (Symbiotic organisms) Obesity Physiological aspects Precision medicine Probiotics Tomography Type 2 diabetes |
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| Title | Effect of probiotics on obesity-related markers per enterotype: a double-blind, placebo-controlled, randomized clinical trial |
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