Reduced Inhibition of Dentate Granule Cells in a Model of Temporal Lobe Epilepsy

• Published in: The Journal of neuroscience Vol. 23; no. 6; pp. 2440 - 2452
• Main Authors: Kobayashi, Masayuki, Buckmaster, Paul S
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 15.03.2003; Society for Neuroscience
• Subjects: Action Potentials; Animals; Atropine Derivatives; Cell Count; Dentate Gyrus - drug effects; Dentate Gyrus - pathology; Dentate Gyrus - physiopathology; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe - chemically induced; Epilepsy, Temporal Lobe - pathology; Epilepsy, Temporal Lobe - physiopathology; Evoked Potentials; In Vitro Techniques; Interneurons - pathology; Male; Membrane Potentials; Neural Inhibition - drug effects; Neurons - drug effects; Neurons - pathology; Neurons - physiology; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A - metabolism; Sensory Thresholds; Status Epilepticus - chemically induced; Status Epilepticus - physiopathology

Patients and models of temporal lobe epilepsy have fewer inhibitory interneurons in the dentate gyrus than controls, but it is unclear whether granule cell inhibition is reduced. We report the loss of GABAergic inhibition of granule cells in the temporal dentate gyrus of pilocarpine-induced epilepti...