Antiemetic Activity of FK1052, a 5-HT3- and 5-HT4-Receptor Antagonist, in Suncus murinus and Ferrets

• Published in: Journal of Pharmacological Sciences Vol. 98; no. 4; pp. 396 - 403
• Main Authors: Nakayama, Hiroe, Yamakuni, Hisashi, Higaki, Mika, Ishikawa, Hirofumi, Imazumi, Katsunori, Matsuo, Masahiko, Mutoh, Seitaro
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 2005; The Japanese Pharmacological Society; Elsevier
• Subjects: acute emesis; Animals; Antiemetics - pharmacology; Cisplatin; Copper Sulfate; delayed emesis; Female; Ferrets; Imidazoles - pharmacology; Indoles - pharmacology; Male; Motion Sickness; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin Antagonists - pharmacology; Shrews; Vomiting - chemically induced; Vomiting - physiopathology; Vomiting - prevention & control; motion sickness; delayed emesis; cisplatin; copper sulfate; acute emesis

We investigated the effect of FK1052 [(+)-8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one hydrochloride], a 5-HT3- and 5-HT4-receptor antagonist, on the emesis induced by motion stimuli, copper sulfate, or cisplatin in either Suncus murinus or ferrets and also...