Estrogen modulation of cortical spreading depression

• Published in: Journal of headache and pain Vol. 24; no. 1; pp. 62 - 12
• Main Authors: Kudo, Chiho, Harriott, Andrea M., Moskowitz, Michael A., Waeber, Christian, Ayata, Cenk
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 26.05.2023; Springer Nature B.V; BMC
• Subjects: 17β-Estradiol; Animals; Aura; Autoradiography; Cerebral cortex; Cortical spreading depression; Cortical Spreading Depression - physiology; Depolarization; Estrogen replacement; Estrogens; Estrogens - pharmacology; Estrus cycle; Female; Females; Glutamates - pharmacology; Gonadal hormones; Gonadectomy; Headache; Internal Medicine; Male; Medicine; Medicine & Public Health; Mental depression; Migraine; Migraine Disorders; Neurology; Neuronal-glial interactions; Ovariectomy; Pain Medicine; Potassium chloride; Progesterone; Progesterone - pharmacology; Rats; Receptor density; Receptors, GABA-A; Sexual dimorphism; Supplements; Susceptibility; Womens health; γ-Aminobutyric acid A receptors; Gonadal hormones; Aura; Migraine; Cortical spreading depression; Estrogen replacement

Background and aims Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a headache trigger. Migraine is three times more prevalent in women than m...