A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion

• Published in: Nature communications Vol. 14; no. 1; pp. 6883 - 16
• Main Authors: Liu, Di-Ao, Tao, Kai, Wu, Bin, Yu, Ziyan, Szczepaniak, Malwina, Rames, Matthew, Yang, Changsong, Svitkina, Tatyana, Zhu, Yueyao, Xu, Fengyuan, Nan, Xiaolin, Guo, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 4-kinase; 13; 14; 631/80/313/2162; 631/80/313/2376; 82/80; Apoptosis; Conversion; Endosomes; Endosomes - metabolism; Exosomes; Exosomes - metabolism; Humanities and Social Sciences; Immune checkpoint; Kinases; Lysosomes; Membranes; Molecular modelling; multidisciplinary; Multivesicular Bodies - metabolism; PD-L1 protein; Phosphatidylinositols - metabolism; Science; Science (multidisciplinary); Tumor cells

Exosomes are secreted to the extracellular milieu when multivesicular endosomes (MVEs) dock and fuse with the plasma membrane. However, MVEs are also known to fuse with lysosomes for degradation. How MVEs are directed to the plasma membrane for exosome secretion rather than to lysosomes is unclear....