Gut microbiota facilitate chronic spontaneous urticaria

• Published in: Nature communications Vol. 15; no. 1; pp. 112 - 17
• Main Authors: Zhu, Lei, Jian, Xingxing, Zhou, Bingjing, Liu, Runqiu, Muñoz, Melba, Sun, Wan, Xie, Lu, Chen, Xiang, Peng, Cong, Maurer, Marcus, Li, Jie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 38; 42; 45; 49; 631/250/256; 631/250/347; 631/326/2565/2134; 692/700; 96; Animal models; Animals; Blood; Blood levels; Chronic Urticaria; Dermatitis; Digestive system; Dysbacteriosis; Dysbiosis - microbiology; Fatty acids; Fatty Acids, Volatile - metabolism; Gastrointestinal Microbiome; Gastrointestinal tract; Gut microbiota; Humanities and Social Sciences; Humans; Inflammation; Inflammatory response; Intestinal microflora; Intestine; Klebsiella; Klebsiella pneumoniae; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Metabolites; Metabolomics; Metagenomics; Mice; Microbiomes; Microbiota; Microorganisms; multidisciplinary; Permeability; Roseburia; Science; Science (multidisciplinary); Skin diseases; Transplantation; Urticaria

Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics and assess the effects of human CSU fecal microbial transplantation, Klebsiella pneumoniae , Roseburia hominis , and metabolit...