Tetravalent Dengue Vaccine Reduces Symptomatic and Asymptomatic Dengue Virus Infections in Healthy Children and Adolescents Aged 2-16 Years in Asia and Latin America

• Published in: Journal of Infectious Diseases Vol. 214; no. 7; pp. 994 - 1000
• Main Authors: Olivera-Botello, Gustavo, Coudeville, Laurent, Fanouillere, Karen, Guy, Bruno, Chambonneau, Laurent, Noriega, Fernando, Jackson, Nicholas
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2016; Oxford University Press (OUP)
• Subjects: Adolescent; Aged; Antibodies, Neutralizing; Antibodies, Neutralizing - blood; Antibodies, Viral; Antibodies, Viral - blood; Asia; Asia - epidemiology; Asymptomatic Diseases; Asymptomatic Diseases - epidemiology; Child; Child, Preschool; Clinical Trials, Phase III as Topic; Dengue; Dengue - epidemiology; Dengue - prevention & control; Dengue Vaccines; Dengue Vaccines - administration & dosage; Dengue Vaccines - immunology; Dengue Virus; Dengue Virus - immunology; Female; Flaviviridae; Humans; Latin America; Latin America - epidemiology; Major and Brief Reports; Major Articles and Brief Reports; Male; Placebos; Placebos - administration & dosage; Treatment Outcome; VIRUSES; Asia; Latin America; Asia; adolescents; children; dengue vaccine; symptomatic dengue virus infection; Latin America; asymptomatic dengue virus infection

Background. Asymptomatic dengue virus-infected individuals are thought to play a major role in dengue virus transmission. The efficacy of the recently approved quadrivalent CYD-TDV dengue vaccine against asymptomatic dengue virus infection has not been previously assessed. Methods. We pooled data fo...