Visualizing the dynamics of tuberculosis pathology using molecular imaging

Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active dis...

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Published inThe Journal of clinical investigation Vol. 131; no. 5; pp. 1 - 11
Main Authors Ordonez, Alvaro A., Tucker, Elizabeth W., Anderson, Carolyn J., Carter, Claire L., Ganatra, Shashank, Kaushal, Deepak, Kramnik, Igor, Lin, Philana L., Madigan, Cressida A., Mendez, Susana, Rao, Jianghong, Savic, Rada M., Tobin, David M., Walzl, Gerhard, Wilkinson, Robert J., Lacourciere, Karen A., Via, Laura E., Jain, Sanjay K.
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.03.2021
Subjects
Animals
Antibiotics
Bacterial infections
Biology
Biomarkers
Biomarkers - metabolism
Biomedical research
Disease
Drug resistance
Enzymes
Evaluation
Glucose
Health aspects
Host-bacteria relationships
Host-pathogen interactions
Humans
Infections
Latent infection
Medical research
Medicine, Experimental
Metabolism
Metabolites
Molecular diagnostic techniques
Molecular Imaging
Mycobacterium tuberculosis
Mycobacterium tuberculosis - metabolism
Pathogenesis
Pathogens
Patients
Prostate
Review
Tuberculosis
Tuberculosis - diagnostic imaging
Tuberculosis - metabolism
United States
Online AccessGet full text
ISSN0021-9738
1558-8238
1558-8238
DOI10.1172/JCI145107

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Abstract Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.
AbstractList Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.
Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.
Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis , tuberculosis (TB) remains a global threat and a deadly human pathogen. M . tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.
Audience Academic
Author Savic, Rada M.
Carter, Claire L.
Rao, Jianghong
Wilkinson, Robert J.
Lin, Philana L.
Lacourciere, Karen A.
Ganatra, Shashank
Anderson, Carolyn J.
Madigan, Cressida A.
Tobin, David M.
Walzl, Gerhard
Jain, Sanjay K.
Kaushal, Deepak
Kramnik, Igor
Mendez, Susana
Ordonez, Alvaro A.
Via, Laura E.
Tucker, Elizabeth W.
AuthorAffiliation 13 Molecular Imaging Program at Stanford, Department of Radiology and Chemistry, Stanford University, Stanford, California, USA
5 Department of Chemistry, University of Missouri, Columbia, Missouri, USA
9 National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA
20 Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, and Tuberculosis Imaging Program, Division of Intramural Research, NIAID, NIH, Bethesda, Maryland, USA
10 Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
19 The Francis Crick Institute, London, United Kingdom
4 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
7 Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA
12 National Institute of Allergy and Infectious Diseases (NIAID), NIH, Rockville, Maryland, USA
3 Department of P
AuthorAffiliation_xml – name: 7 Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA
– name: 16 SAMRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
– name: 1 Center for Infection and Inflammation Imaging Research
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33645551$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright COPYRIGHT 2021 American Society for Clinical Investigation
Copyright American Society for Clinical Investigation Mar 2021
2021 Ordonez et al. 2021 Ordonez et al.
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Snippet Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M....
Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis , tuberculosis (TB) remains a global threat and a deadly human pathogen. M ....
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SubjectTerms Animals
Antibiotics
Bacterial infections
Biology
Biomarkers
Biomarkers - metabolism
Biomedical research
Disease
Drug resistance
Enzymes
Evaluation
Glucose
Health aspects
Host-bacteria relationships
Host-pathogen interactions
Humans
Infections
Latent infection
Medical research
Medicine, Experimental
Metabolism
Metabolites
Molecular diagnostic techniques
Molecular Imaging
Mycobacterium tuberculosis
Mycobacterium tuberculosis - metabolism
Pathogenesis
Pathogens
Patients
Prostate
Review
Tuberculosis
Tuberculosis - diagnostic imaging
Tuberculosis - metabolism
Title Visualizing the dynamics of tuberculosis pathology using molecular imaging
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