Multiple factors contribute to flight behaviors during fear conditioning
Shifting defensive mode from one to another by the imminence of threat is crucial for survival. The transition of defensive mode from freezing to flight is observed during the modified fear conditioning, however, the flight during fear conditioning is not well characterized. To characterize the flig...
Saved in:
| Published in | Scientific reports Vol. 13; no. 1; pp. 10402 - 14 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
27.06.2023
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Shifting defensive mode from one to another by the imminence of threat is crucial for survival. The transition of defensive mode from freezing to flight is observed during the modified fear conditioning, however, the flight during fear conditioning is not well characterized. To characterize the flight behaviors during the fear conditioning, we conducted experiments in male mice focusing on the influence of the context, the intensity of the unconditioned stimulus and conditioned stimulus (CS), the schedule of conditioning, and the state of the subject. Flight behaviors triggered by salient CS showed characteristics of fear-potentiated defensive behaviors depending on the conditioned context, while repetitive conditioning enhanced the expression of the flight and developed an association between the CS and the flight. The salient auditory stimulus was the primary factor to trigger flight behaviors. Also, the spaced conditioning increased the expression of flight behaviors. Taken together, the flight behavior during fear conditioning is not a simple conditioned response nor simple fear-potentiated behavior, but a complicated mixture of multiple components of defensive behaviors. The transition of defensive mode could be induced by the integration of multiple innate and learned components of fear or anxiety. |
|---|---|
| AbstractList | Shifting defensive mode from one to another by the imminence of threat is crucial for survival. The transition of defensive mode from freezing to flight is observed during the modified fear conditioning, however, the flight during fear conditioning is not well characterized. To characterize the flight behaviors during the fear conditioning, we conducted experiments in male mice focusing on the influence of the context, the intensity of the unconditioned stimulus and conditioned stimulus (CS), the schedule of conditioning, and the state of the subject. Flight behaviors triggered by salient CS showed characteristics of fear-potentiated defensive behaviors depending on the conditioned context, while repetitive conditioning enhanced the expression of the flight and developed an association between the CS and the flight. The salient auditory stimulus was the primary factor to trigger flight behaviors. Also, the spaced conditioning increased the expression of flight behaviors. Taken together, the flight behavior during fear conditioning is not a simple conditioned response nor simple fear-potentiated behavior, but a complicated mixture of multiple components of defensive behaviors. The transition of defensive mode could be induced by the integration of multiple innate and learned components of fear or anxiety. Shifting defensive mode from one to another by the imminence of threat is crucial for survival. The transition of defensive mode from freezing to flight is observed during the modified fear conditioning, however, the flight during fear conditioning is not well characterized. To characterize the flight behaviors during the fear conditioning, we conducted experiments in male mice focusing on the influence of the context, the intensity of the unconditioned stimulus and conditioned stimulus (CS), the schedule of conditioning, and the state of the subject. Flight behaviors triggered by salient CS showed characteristics of fear-potentiated defensive behaviors depending on the conditioned context, while repetitive conditioning enhanced the expression of the flight and developed an association between the CS and the flight. The salient auditory stimulus was the primary factor to trigger flight behaviors. Also, the spaced conditioning increased the expression of flight behaviors. Taken together, the flight behavior during fear conditioning is not a simple conditioned response nor simple fear-potentiated behavior, but a complicated mixture of multiple components of defensive behaviors. The transition of defensive mode could be induced by the integration of multiple innate and learned components of fear or anxiety.Shifting defensive mode from one to another by the imminence of threat is crucial for survival. The transition of defensive mode from freezing to flight is observed during the modified fear conditioning, however, the flight during fear conditioning is not well characterized. To characterize the flight behaviors during the fear conditioning, we conducted experiments in male mice focusing on the influence of the context, the intensity of the unconditioned stimulus and conditioned stimulus (CS), the schedule of conditioning, and the state of the subject. Flight behaviors triggered by salient CS showed characteristics of fear-potentiated defensive behaviors depending on the conditioned context, while repetitive conditioning enhanced the expression of the flight and developed an association between the CS and the flight. The salient auditory stimulus was the primary factor to trigger flight behaviors. Also, the spaced conditioning increased the expression of flight behaviors. Taken together, the flight behavior during fear conditioning is not a simple conditioned response nor simple fear-potentiated behavior, but a complicated mixture of multiple components of defensive behaviors. The transition of defensive mode could be induced by the integration of multiple innate and learned components of fear or anxiety. Abstract Shifting defensive mode from one to another by the imminence of threat is crucial for survival. The transition of defensive mode from freezing to flight is observed during the modified fear conditioning, however, the flight during fear conditioning is not well characterized. To characterize the flight behaviors during the fear conditioning, we conducted experiments in male mice focusing on the influence of the context, the intensity of the unconditioned stimulus and conditioned stimulus (CS), the schedule of conditioning, and the state of the subject. Flight behaviors triggered by salient CS showed characteristics of fear-potentiated defensive behaviors depending on the conditioned context, while repetitive conditioning enhanced the expression of the flight and developed an association between the CS and the flight. The salient auditory stimulus was the primary factor to trigger flight behaviors. Also, the spaced conditioning increased the expression of flight behaviors. Taken together, the flight behavior during fear conditioning is not a simple conditioned response nor simple fear-potentiated behavior, but a complicated mixture of multiple components of defensive behaviors. The transition of defensive mode could be induced by the integration of multiple innate and learned components of fear or anxiety. |
| ArticleNumber | 10402 |
| Author | Furuyama, Takafumi Imayoshi, Ayana Kato, Nobuo Yamamoto, Ryo Iyobe, Toyo Ishikawa, Tatsuya Ozaki, Noriyuki Ono, Munenori |
| Author_xml | – sequence: 1 givenname: Takafumi surname: Furuyama fullname: Furuyama, Takafumi email: tfuruyam@kanazawa-med.ac.jp organization: Department of Physiology, Kanazawa Medical University – sequence: 2 givenname: Ayana surname: Imayoshi fullname: Imayoshi, Ayana organization: Department of Physiology, Kanazawa Medical University – sequence: 3 givenname: Toyo surname: Iyobe fullname: Iyobe, Toyo organization: Department of Physiology, Kanazawa Medical University – sequence: 4 givenname: Munenori surname: Ono fullname: Ono, Munenori organization: Department of Physiology, Kanazawa Medical University – sequence: 5 givenname: Tatsuya surname: Ishikawa fullname: Ishikawa, Tatsuya organization: Department of Functional Anatomy, Graduate School of Medical Science, Kanazawa University – sequence: 6 givenname: Noriyuki surname: Ozaki fullname: Ozaki, Noriyuki organization: Department of Functional Anatomy, Graduate School of Medical Science, Kanazawa University – sequence: 7 givenname: Nobuo surname: Kato fullname: Kato, Nobuo organization: Department of Physiology, Kanazawa Medical University – sequence: 8 givenname: Ryo surname: Yamamoto fullname: Yamamoto, Ryo email: ryamamot@kanazawa-med.ac.jp organization: Department of Physiology, Kanazawa Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37369752$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uk1v3CAQRVGqJE3zB3qoLPXSi1sYsI1PVRWlTaRUvbRnBBh2WbFmCzhS_n3wOt-HcAHNvHnzHjPv0eEYRoPQR4K_Ekz5t8RI0_MaA61p1xKo8QE6AcyaGijA4bP3MTpLaYPLaaBnpD9Cx7Sjbd81cIIuf08-u503lZU6h5gqHcYcnZqyqXKorHerda6UWcsbN6eHKbpxVVkj4wwdXHZhLJEP6J2VPpmz-_sU_ft58ff8sr7-8-vq_Md1rVvc5ZpoaaFIaU0LRBHVNNxiBYz3LW8w48AkV9o0WlFlGe8YLu4s6AFL1gPh9BRdLbxDkBuxi24r460I0ol9IMSVkDE77Y0ggOVAjR2kbdkAmA_KEguK2tKmdCtc3xeu3aS2ZtCmOJf-BenLzOjWYhVuRJlA8dCRwvDlniGG_5NJWWxd0sZ7OZowJQGc4rbDtOkK9PMr6CZMcSx_tUdhQhmjBfXpuaRHLQ8TKwBYADqGlKKxjxCCZ11cLJshymaI_WaI2Sh_VaRdlvPkii3n3y6lS2nazYM38Un2G1V3eibL_Q |
| CitedBy_id | crossref_primary_10_7554_eLife_90414 crossref_primary_10_7554_eLife_90414_3 |
| Cites_doi | 10.1176/appi.books.9780890425596 10.1016/j.bbr.2004.11.003 10.1152/jn.1995.73.1.141 10.1016/S0306-4522(00)00484-X 10.1016/j.neuropharm.2011.07.004 10.3389/fnbeh.2019.00045 10.1007/BF00427474 10.1016/j.tics.2019.12.016 10.1037/0735-7044.100.6.814 10.1037/0735-7044.122.2.282 10.1016/0378-5955(84)90005-4 10.1111/j.1749-6632.2003.tb07077.x 10.1056/NEJM199305133281907 10.1016/j.neuron.2021.05.017 10.1016/j.neuropharm.2012.11.025 10.1037/h0026779 10.1016/j.bbr.2004.07.007 10.1038/s41598-021-87559-3 10.1038/nature21047 10.7554/eLife.75663 10.3758/BF03210947 10.3758/BF03212284 10.1016/j.bbr.2006.05.016 10.7554/eLife.53803 10.1016/j.physbeh.2023.114146 10.1016/j.neuron.2007.09.006 10.1111/j.1749-6632.1989.tb42197.x 10.3389/fphar.2022.826783 10.7554/eLife.11352 10.1016/j.bbr.2020.112623 10.1037/0735-7044.111.4.855 10.1016/S0091-3057(99)00216-6 10.1101/lm.053587.122 10.1016/0031-9384(91)90286-W 10.1111/gbb.12208 10.7554/eLife.82711 10.1146/annurev.neuro.23.1.155 10.1016/0091-3057(95)02084-5 10.1038/s41467-021-21248-7 10.1037/0033-295X.107.2.289 10.1201/9781420038736 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023 2023. The Author(s). The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2023 – notice: 2023. The Author(s). – notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.1038/s41598-023-37612-0 |
| DatabaseName | Springer Nature OA Free Journals CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Collection (ProQuest) ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database (ProQuest) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed Publicly Available Content Database CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 14 |
| ExternalDocumentID | oai_doaj_org_article_120ad3efdaf64d208dbf1f2b3f824850 PMC10300071 37369752 10_1038_s41598_023_37612_0 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Japan Society for the Promotion of Science grantid: 22K15795; 23K08377 funderid: http://dx.doi.org/10.13039/501100001691 – fundername: Japan Society for the Promotion of Science,Japan grantid: 21K06731; 22K09734; 21K07489 – fundername: Kanazawa Medical University grantid: C2022-3 funderid: http://dx.doi.org/10.13039/501100004043 – fundername: Japan Society for the Promotion of Science,Japan grantid: 21K06731 – fundername: Japan Society for the Promotion of Science grantid: 22K15795 – fundername: Japan Society for the Promotion of Science grantid: 23K08377 – fundername: Japan Society for the Promotion of Science,Japan grantid: 21K07489 – fundername: Kanazawa Medical University grantid: C2022-3 – fundername: Japan Society for the Promotion of Science,Japan grantid: 22K09734 – fundername: ; grantid: 22K15795; 23K08377 – fundername: ; grantid: 21K06731; 22K09734; 21K07489 – fundername: ; grantid: C2022-3 |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFPKN CITATION PHGZM PHGZT NPM 7XB 8FK AARCD K9. PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c607t-1caf20006e621b1b558f0b248968504824a8bce5cb3bf48740376f2cd0a492183 |
| IEDL.DBID | M48 |
| ISSN | 2045-2322 |
| IngestDate | Wed Aug 27 01:25:28 EDT 2025 Thu Aug 21 18:37:59 EDT 2025 Tue Aug 05 09:26:39 EDT 2025 Wed Aug 13 10:59:31 EDT 2025 Wed Feb 19 02:23:49 EST 2025 Tue Jul 01 04:24:57 EDT 2025 Thu Apr 24 23:07:00 EDT 2025 Fri Feb 21 02:37:35 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2023. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c607t-1caf20006e621b1b558f0b248968504824a8bce5cb3bf48740376f2cd0a492183 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41598-023-37612-0 |
| PMID | 37369752 |
| PQID | 2830013443 |
| PQPubID | 2041939 |
| PageCount | 14 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_120ad3efdaf64d208dbf1f2b3f824850 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10300071 proquest_miscellaneous_2830670357 proquest_journals_2830013443 pubmed_primary_37369752 crossref_primary_10_1038_s41598_023_37612_0 crossref_citationtrail_10_1038_s41598_023_37612_0 springer_journals_10_1038_s41598_023_37612_0 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-06-27 |
| PublicationDateYYYYMMDD | 2023-06-27 |
| PublicationDate_xml | – month: 06 year: 2023 text: 2023-06-27 day: 27 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2023 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | ShaderRIGreenblattDJUse of benzodiazepines in anxiety disordersN. Engl. J. Med.1993328139814051:STN:280:DyaK3s3jtlOgsA%3D%3D829211510.1056/NEJM199305133281907 MitchellJRTrettelSGLiAJWasielewskiSHuckleberryKAFanikosMGoldenELaineMAShanskyRMDarting across space and time: parametric modulators of sex-biased conditioned fear responsesLearn. Mem.2022291711803571030410.1101/lm.053587.122 LeeJLDickinsonAEverittBJConditioned suppression and freezing as measures of aversive Pavlovian conditioning: effects of discrete amygdala lesions and overtrainingBehav. Brain Res.20051592212331581718510.1016/j.bbr.2004.11.003 InoueTTsuchiyaKKoyamaTSerotonergic activation reduces defensive freezing in the conditioned fear paradigmPharmacol. Biochem. Behav.1996538258311:CAS:528:DyaK28XhvFersLw%3D880158410.1016/0091-3057(95)02084-5 MeliaKRDavisMEffects of septal lesions on fear-potentiated startle, and on the anxiolytic effects of buspirone and diazepamPhysiol. Behav.1991496036111:STN:280:DyaK3M3ovVKksw%3D%3D164824410.1016/0031-9384(91)90286-W GrueneTMFlickKStefanoASheaSDShanskyRMSexually divergent expression of active and passive conditioned fear responses in ratsElife20154e1135226568307470926010.7554/eLife.11352 ResstelLBJocaSRMoreiraFACorrêaFMGuimarãesFSEffects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in ratsBehav. Brain Res.20061722942981678096610.1016/j.bbr.2006.05.016 LeDouxJEEmotion circuits in the brainAnnu. Rev. Neurosci.2000231551841:CAS:528:DC%2BD3cXjs1Gmsr4%3D1084506210.1146/annurev.neuro.23.1.155 LiZWeiJXZhangGWHuangJJZinggBWangXTaoHWZhangLICorticostriatal control of defense behavior in mice induced by auditory looming cuesNat. Commun.20211210402021NatCo..12.1040L1:CAS:528:DC%2BB3MXksV2qsLs%3D33589613788470210.1038/s41467-021-21248-7 BlanchardRJBlanchardDCCrouching as an index of fearJ. Comp. Physiol. Psychol.1969673703751:STN:280:DyaF1M3htF2jtg%3D%3D578738810.1037/h0026779 SandiCMerinoJJCorderoMITouyarotKVeneroCEffects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1Neuroscience20011023293391:CAS:528:DC%2BD3MXpslyiuw%3D%3D1116611910.1016/S0306-4522(00)00484-X WillottJFHandbook of Mouse Auditory Research2001CRC Press10.1201/9781420038736 DavisMPharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigmBehav. Neurosci.19861008148241:CAS:528:DyaL2sXhtlWjtbY%3D354525710.1037/0735-7044.100.6.814 PengJMaXChenYYanJJiangHC57BL/6J and C57BL/6N mice exhibit different neuro-behaviors and sensitivity to midazolam- and propofol-induced anesthesiaPhysiol. Behav.20232641141461:CAS:528:DC%2BB3sXlsFags7k%3D3688948710.1016/j.physbeh.2023.114146 JohnsonLRMcGuireJLazarusRPalmerAAPavlovian fear memory circuits and phenotype models of PTSDNeuropharmacology2012626386461:CAS:528:DC%2BC38XhtFCktr4%3D2178283310.1016/j.neuropharm.2011.07.004 BienvenuTCMDejeanCJercogDAouizerateBLemoineMHerryCThe advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD researchNeuron2021109238023971:CAS:528:DC%2BB3MXhtlKrtbjO3414647010.1016/j.neuron.2021.05.017 McCaughranJAJrBellJ3rdHitzemannRJFear-potentiated startle response in mice: Genetic analysis of the C57BL/6J and DBA/2J intercrossPharmacol. Biochem. Behav.2000653013121:CAS:528:DC%2BD3cXhtVaisL4%3D1067298310.1016/S0091-3057(99)00216-6 HersmanSAllenDHashimotoMBritoSIAnthonyTEStimulus salience determines defensive behaviors elicited by aversively conditioned serial compound auditory stimuliElife20209e5380332216876719035010.7554/eLife.53803 FanselowMSLesterLSA functional Behavioristic Approach to Aversively Motivated Behavior: Predatory Imminence as a Determinant of the Topography Of Defensive Behavior1988Lawrence Erlbaum Associates, Inc WillottJFKuligJSatterfieldTThe acoustic startle response in DBA/2 and C57BL/6 mice: Relationship to auditory neuronal response properties and hearing impairmentHear Res.1984161611671:STN:280:DyaL2M7jtVKhsQ%3D%3D652674710.1016/0378-5955(84)90005-4 FanselowMSThe postshock activity burstAnim. Learn. Behav.19821044845410.3758/BF03212284 BoutonMELearning and Behavior: A Contemporary Synthesis2007Sinauer Associates Inc. FallsWACarlsonSTurnerJGWillottJFFear-potentiated startle in two strains of inbred miceBehav. Neurosci.19971118558611:STN:280:DyaK2svhtlShsw%3D%3D926766410.1037/0735-7044.111.4.855 FadokJPKrabbeSMarkovicMCourtinJXuCMassiLBottaPBylundKMüllerCKovacevicATovotePLüthiAA competitive inhibitory circuit for selection of active and passive fear responsesNature2017542961002017Natur.542...96F1:CAS:528:DC%2BC2sXhsFGltrc%3D2811743910.1038/nature21047 FanselowMSGaleGDThe amygdala, fear, and memoryAnn. N. Y. Acad. Sci.20039851251342003NYASA.985..125F1272415410.1111/j.1749-6632.2003.tb07077.x SaitohASugiyamaAYamadaMInagakiMOkaJNagaseHYamadaMThe novel δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepinesNeuropharmacology2013674854931:CAS:528:DC%2BC3sXhs1Cjsbo%3D2324653110.1016/j.neuropharm.2012.11.025 TottyMSWarrenNHuddlestonIRamanathanKRResslerRLOleksiakCRMarenSBehavioral and brain mechanisms mediating conditioned flight behavior in ratsSci. Rep.20211182151:CAS:528:DC%2BB3MXpt1WksLg%3D33859260805006910.1038/s41598-021-87559-3 SturmMBeckerASchroederABilkei-GorzoAZimmerAEffect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J miceGenes Brain Behav.2015142923001:CAS:528:DC%2BC2MXlsVKjurc%3D2575247510.1111/gbb.12208 MatsuoNTakaoKNakanishiKYamasakiNTandaKMiyakawaTBehavioral profiles of three C57BL/6 substrainsFront. Behav. Neurosci.2010429206762342912075 Colom-LapetinaJLiAJPelegrina-PerezTCShanskyRMBehavioral diversity across classic rodent models is sex-dependentFront. Behav. Neurosci.2019134530894806641441510.3389/fnbeh.2019.00045 SiegmundALangnaeseKWotjakCTDifferences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synucleinBehav. Brain Res.20051572912981:CAS:528:DC%2BD2MXisl2ntw%3D%3D1563918010.1016/j.bbr.2004.07.007 WinterIMPalmerARLevel dependence of cochlear nucleus onset unit responses and facilitation by second tones or broadband noiseJ Neurophysiol.1995731411591:STN:280:DyaK2M3jtVehtg%3D%3D771456010.1152/jn.1995.73.1.141 GoedhoopJNvan den BoomBJGRobkeRVeenFFellingerLvan ElzelingenWArbabTWilluhnINucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction errorElife202211e8271136366962965194510.7554/eLife.82711 DantzerRMormedePFavreBFear-dependent variations in continuous avoidance behavior of pigs. II. Effects of diazepam on acquisition and performance of Pavlovian fear conditioning and plasma corticosteroid levelsPsychopharmacology19764975781:CAS:528:DyaE28XltFKku7k%3D82245110.1007/BF00427474 American Psychiatric Association. DSM-5: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (American Psychiatric Association). 2013. YehudaRLeDouxJResponse variation following trauma: A translational neuroscience approach to understanding PTSDNeuron20075619321:CAS:528:DC%2BD2sXht1Wksr%2FK1792001210.1016/j.neuron.2007.09.006 GallistelCRGibbonJTime, rate, and conditioningPsychol. Rev.20001072893441:STN:280:DC%2BD3c3kvFKktg%3D%3D1078919810.1037/0033-295X.107.2.289 TrottJMHoffmanANZhuravkaIFanselowMSConditional and unconditional components of aversively motivated freezing, flight and darting in miceElife202211e756631:CAS:528:DC%2BB38XitlCmsLrO35616523917374510.7554/eLife.75663 BorkarCDDorofeikovaMLeQEVutukuriRVoCHerefordDResendezABasavanhalliSSifnugelNFadokJPSex differences in behavioral responses during a conditioned flight paradigmBehav. Brain Res.20203891126233234887210.1016/j.bbr.2020.112623 SaitohANagayamaYYamadaDMakinoKYoshiokaTYamanakaNNakataniMTakahashiYYamazakiMShigemotoCOhashiMOkanoKOmataTTodaESanoYTakahashiHMatsushimaKTerashimaYDisulfiram produces potent anxiolytic-like effects without benzodiazepine anxiolytics-related adverse effects in miceFront. Pharmacol.2022138267831:CAS:528:DC%2BB38XhtlWjtb3E35330835894023210.3389/fphar.2022.826783 MobbsDHeadleyDBDingWDayanPSpace, time, and fear: Survival computations along defensive circuitsTrends Cogn. Sci.2020242282413202936010.1016/j.tics.2019.12.016 FanselowMSNeural organization of the defensive behavior system responsible for fearPsychon. Bull. Rev.199414294381:STN:280:DC%2BC2c7ktV2jtw%3D%3D2420355110.3758/BF03210947 WoodGENorrisEHWatersEStoldtJTMcEwenBSChronic immobilization stress alters aspects of emotionality and associative learning in the ratBehav. Neurosci.20081222822921841016810.1037/0735-7044.122.2.282 DavisMNeural systems involved in fear-potentiated startleAnn. N. Y. Acad. Sci.19895631651831989NYASA.563..165D1:STN:280:DyaL1Mznt1Gmtw%3D%3D257054510.1111/j.1749-6632.1989.tb42197.x JE LeDoux (37612_CR5) 2000; 23 R Yehuda (37612_CR6) 2007; 56 TCM Bienvenu (37612_CR8) 2021; 109 37612_CR4 C Sandi (37612_CR20) 2001; 102 R Dantzer (37612_CR29) 1976; 49 RJ Blanchard (37612_CR9) 1969; 67 CD Borkar (37612_CR32) 2020; 389 JF Willott (37612_CR33) 2001 A Saitoh (37612_CR43) 2013; 67 MS Totty (37612_CR13) 2021; 11 RI Shader (37612_CR24) 1993; 328 TM Gruene (37612_CR14) 2015; 4 IM Winter (37612_CR34) 1995; 73 LB Resstel (37612_CR31) 2006; 172 M Sturm (37612_CR27) 2015; 14 JM Trott (37612_CR17) 2022; 11 M Davis (37612_CR41) 1986; 100 M Davis (37612_CR38) 1989; 563 ME Bouton (37612_CR22) 2007 GE Wood (37612_CR23) 2008; 122 J Colom-Lapetina (37612_CR15) 2019; 13 N Matsuo (37612_CR26) 2010; 4 MS Fanselow (37612_CR2) 1994; 1 JF Willott (37612_CR37) 1984; 16 JL Lee (37612_CR21) 2005; 159 KR Melia (37612_CR42) 1991; 49 MS Fanselow (37612_CR10) 2003; 985 JP Fadok (37612_CR11) 2017; 542 J Peng (37612_CR28) 2023; 264 T Inoue (37612_CR30) 1996; 53 JR Mitchell (37612_CR16) 2022; 29 Z Li (37612_CR36) 2021; 12 MS Fanselow (37612_CR1) 1988 A Siegmund (37612_CR25) 2005; 157 JA McCaughran Jr (37612_CR40) 2000; 65 WA Falls (37612_CR39) 1997; 111 MS Fanselow (37612_CR18) 1982; 10 S Hersman (37612_CR12) 2020; 9 LR Johnson (37612_CR7) 2012; 62 D Mobbs (37612_CR3) 2020; 24 A Saitoh (37612_CR44) 2022; 13 CR Gallistel (37612_CR19) 2000; 107 JN Goedhoop (37612_CR35) 2022; 11 |
| References_xml | – reference: MobbsDHeadleyDBDingWDayanPSpace, time, and fear: Survival computations along defensive circuitsTrends Cogn. Sci.2020242282413202936010.1016/j.tics.2019.12.016 – reference: SturmMBeckerASchroederABilkei-GorzoAZimmerAEffect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J miceGenes Brain Behav.2015142923001:CAS:528:DC%2BC2MXlsVKjurc%3D2575247510.1111/gbb.12208 – reference: GoedhoopJNvan den BoomBJGRobkeRVeenFFellingerLvan ElzelingenWArbabTWilluhnINucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction errorElife202211e8271136366962965194510.7554/eLife.82711 – reference: BorkarCDDorofeikovaMLeQEVutukuriRVoCHerefordDResendezABasavanhalliSSifnugelNFadokJPSex differences in behavioral responses during a conditioned flight paradigmBehav. Brain Res.20203891126233234887210.1016/j.bbr.2020.112623 – reference: FanselowMSThe postshock activity burstAnim. Learn. Behav.19821044845410.3758/BF03212284 – reference: BoutonMELearning and Behavior: A Contemporary Synthesis2007Sinauer Associates Inc. – reference: FanselowMSGaleGDThe amygdala, fear, and memoryAnn. N. Y. Acad. Sci.20039851251342003NYASA.985..125F1272415410.1111/j.1749-6632.2003.tb07077.x – reference: McCaughranJAJrBellJ3rdHitzemannRJFear-potentiated startle response in mice: Genetic analysis of the C57BL/6J and DBA/2J intercrossPharmacol. Biochem. Behav.2000653013121:CAS:528:DC%2BD3cXhtVaisL4%3D1067298310.1016/S0091-3057(99)00216-6 – reference: TottyMSWarrenNHuddlestonIRamanathanKRResslerRLOleksiakCRMarenSBehavioral and brain mechanisms mediating conditioned flight behavior in ratsSci. Rep.20211182151:CAS:528:DC%2BB3MXpt1WksLg%3D33859260805006910.1038/s41598-021-87559-3 – reference: FallsWACarlsonSTurnerJGWillottJFFear-potentiated startle in two strains of inbred miceBehav. Neurosci.19971118558611:STN:280:DyaK2svhtlShsw%3D%3D926766410.1037/0735-7044.111.4.855 – reference: BlanchardRJBlanchardDCCrouching as an index of fearJ. Comp. Physiol. Psychol.1969673703751:STN:280:DyaF1M3htF2jtg%3D%3D578738810.1037/h0026779 – reference: MeliaKRDavisMEffects of septal lesions on fear-potentiated startle, and on the anxiolytic effects of buspirone and diazepamPhysiol. Behav.1991496036111:STN:280:DyaK3M3ovVKksw%3D%3D164824410.1016/0031-9384(91)90286-W – reference: FadokJPKrabbeSMarkovicMCourtinJXuCMassiLBottaPBylundKMüllerCKovacevicATovotePLüthiAA competitive inhibitory circuit for selection of active and passive fear responsesNature2017542961002017Natur.542...96F1:CAS:528:DC%2BC2sXhsFGltrc%3D2811743910.1038/nature21047 – reference: MitchellJRTrettelSGLiAJWasielewskiSHuckleberryKAFanikosMGoldenELaineMAShanskyRMDarting across space and time: parametric modulators of sex-biased conditioned fear responsesLearn. Mem.2022291711803571030410.1101/lm.053587.122 – reference: DantzerRMormedePFavreBFear-dependent variations in continuous avoidance behavior of pigs. II. Effects of diazepam on acquisition and performance of Pavlovian fear conditioning and plasma corticosteroid levelsPsychopharmacology19764975781:CAS:528:DyaE28XltFKku7k%3D82245110.1007/BF00427474 – reference: FanselowMSLesterLSA functional Behavioristic Approach to Aversively Motivated Behavior: Predatory Imminence as a Determinant of the Topography Of Defensive Behavior1988Lawrence Erlbaum Associates, Inc – reference: DavisMPharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigmBehav. Neurosci.19861008148241:CAS:528:DyaL2sXhtlWjtbY%3D354525710.1037/0735-7044.100.6.814 – reference: YehudaRLeDouxJResponse variation following trauma: A translational neuroscience approach to understanding PTSDNeuron20075619321:CAS:528:DC%2BD2sXht1Wksr%2FK1792001210.1016/j.neuron.2007.09.006 – reference: ResstelLBJocaSRMoreiraFACorrêaFMGuimarãesFSEffects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in ratsBehav. Brain Res.20061722942981678096610.1016/j.bbr.2006.05.016 – reference: GallistelCRGibbonJTime, rate, and conditioningPsychol. Rev.20001072893441:STN:280:DC%2BD3c3kvFKktg%3D%3D1078919810.1037/0033-295X.107.2.289 – reference: PengJMaXChenYYanJJiangHC57BL/6J and C57BL/6N mice exhibit different neuro-behaviors and sensitivity to midazolam- and propofol-induced anesthesiaPhysiol. Behav.20232641141461:CAS:528:DC%2BB3sXlsFags7k%3D3688948710.1016/j.physbeh.2023.114146 – reference: WinterIMPalmerARLevel dependence of cochlear nucleus onset unit responses and facilitation by second tones or broadband noiseJ Neurophysiol.1995731411591:STN:280:DyaK2M3jtVehtg%3D%3D771456010.1152/jn.1995.73.1.141 – reference: DavisMNeural systems involved in fear-potentiated startleAnn. N. Y. Acad. Sci.19895631651831989NYASA.563..165D1:STN:280:DyaL1Mznt1Gmtw%3D%3D257054510.1111/j.1749-6632.1989.tb42197.x – reference: BienvenuTCMDejeanCJercogDAouizerateBLemoineMHerryCThe advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD researchNeuron2021109238023971:CAS:528:DC%2BB3MXhtlKrtbjO3414647010.1016/j.neuron.2021.05.017 – reference: HersmanSAllenDHashimotoMBritoSIAnthonyTEStimulus salience determines defensive behaviors elicited by aversively conditioned serial compound auditory stimuliElife20209e5380332216876719035010.7554/eLife.53803 – reference: TrottJMHoffmanANZhuravkaIFanselowMSConditional and unconditional components of aversively motivated freezing, flight and darting in miceElife202211e756631:CAS:528:DC%2BB38XitlCmsLrO35616523917374510.7554/eLife.75663 – reference: SaitohANagayamaYYamadaDMakinoKYoshiokaTYamanakaNNakataniMTakahashiYYamazakiMShigemotoCOhashiMOkanoKOmataTTodaESanoYTakahashiHMatsushimaKTerashimaYDisulfiram produces potent anxiolytic-like effects without benzodiazepine anxiolytics-related adverse effects in miceFront. Pharmacol.2022138267831:CAS:528:DC%2BB38XhtlWjtb3E35330835894023210.3389/fphar.2022.826783 – reference: LeDouxJEEmotion circuits in the brainAnnu. Rev. Neurosci.2000231551841:CAS:528:DC%2BD3cXjs1Gmsr4%3D1084506210.1146/annurev.neuro.23.1.155 – reference: MatsuoNTakaoKNakanishiKYamasakiNTandaKMiyakawaTBehavioral profiles of three C57BL/6 substrainsFront. Behav. Neurosci.2010429206762342912075 – reference: SiegmundALangnaeseKWotjakCTDifferences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synucleinBehav. Brain Res.20051572912981:CAS:528:DC%2BD2MXisl2ntw%3D%3D1563918010.1016/j.bbr.2004.07.007 – reference: American Psychiatric Association. DSM-5: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (American Psychiatric Association). 2013. – reference: ShaderRIGreenblattDJUse of benzodiazepines in anxiety disordersN. Engl. J. Med.1993328139814051:STN:280:DyaK3s3jtlOgsA%3D%3D829211510.1056/NEJM199305133281907 – reference: WoodGENorrisEHWatersEStoldtJTMcEwenBSChronic immobilization stress alters aspects of emotionality and associative learning in the ratBehav. Neurosci.20081222822921841016810.1037/0735-7044.122.2.282 – reference: WillottJFKuligJSatterfieldTThe acoustic startle response in DBA/2 and C57BL/6 mice: Relationship to auditory neuronal response properties and hearing impairmentHear Res.1984161611671:STN:280:DyaL2M7jtVKhsQ%3D%3D652674710.1016/0378-5955(84)90005-4 – reference: SaitohASugiyamaAYamadaMInagakiMOkaJNagaseHYamadaMThe novel δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepinesNeuropharmacology2013674854931:CAS:528:DC%2BC3sXhs1Cjsbo%3D2324653110.1016/j.neuropharm.2012.11.025 – reference: Colom-LapetinaJLiAJPelegrina-PerezTCShanskyRMBehavioral diversity across classic rodent models is sex-dependentFront. Behav. Neurosci.2019134530894806641441510.3389/fnbeh.2019.00045 – reference: JohnsonLRMcGuireJLazarusRPalmerAAPavlovian fear memory circuits and phenotype models of PTSDNeuropharmacology2012626386461:CAS:528:DC%2BC38XhtFCktr4%3D2178283310.1016/j.neuropharm.2011.07.004 – reference: LiZWeiJXZhangGWHuangJJZinggBWangXTaoHWZhangLICorticostriatal control of defense behavior in mice induced by auditory looming cuesNat. Commun.20211210402021NatCo..12.1040L1:CAS:528:DC%2BB3MXksV2qsLs%3D33589613788470210.1038/s41467-021-21248-7 – reference: SandiCMerinoJJCorderoMITouyarotKVeneroCEffects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1Neuroscience20011023293391:CAS:528:DC%2BD3MXpslyiuw%3D%3D1116611910.1016/S0306-4522(00)00484-X – reference: InoueTTsuchiyaKKoyamaTSerotonergic activation reduces defensive freezing in the conditioned fear paradigmPharmacol. Biochem. Behav.1996538258311:CAS:528:DyaK28XhvFersLw%3D880158410.1016/0091-3057(95)02084-5 – reference: FanselowMSNeural organization of the defensive behavior system responsible for fearPsychon. Bull. Rev.199414294381:STN:280:DC%2BC2c7ktV2jtw%3D%3D2420355110.3758/BF03210947 – reference: GrueneTMFlickKStefanoASheaSDShanskyRMSexually divergent expression of active and passive conditioned fear responses in ratsElife20154e1135226568307470926010.7554/eLife.11352 – reference: LeeJLDickinsonAEverittBJConditioned suppression and freezing as measures of aversive Pavlovian conditioning: effects of discrete amygdala lesions and overtrainingBehav. Brain Res.20051592212331581718510.1016/j.bbr.2004.11.003 – reference: WillottJFHandbook of Mouse Auditory Research2001CRC Press10.1201/9781420038736 – ident: 37612_CR4 doi: 10.1176/appi.books.9780890425596 – volume: 159 start-page: 221 year: 2005 ident: 37612_CR21 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2004.11.003 – volume: 73 start-page: 141 year: 1995 ident: 37612_CR34 publication-title: J Neurophysiol. doi: 10.1152/jn.1995.73.1.141 – volume: 102 start-page: 329 year: 2001 ident: 37612_CR20 publication-title: Neuroscience doi: 10.1016/S0306-4522(00)00484-X – volume: 62 start-page: 638 year: 2012 ident: 37612_CR7 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2011.07.004 – volume: 13 start-page: 45 year: 2019 ident: 37612_CR15 publication-title: Front. Behav. Neurosci. doi: 10.3389/fnbeh.2019.00045 – volume: 49 start-page: 75 year: 1976 ident: 37612_CR29 publication-title: Psychopharmacology doi: 10.1007/BF00427474 – volume: 24 start-page: 228 year: 2020 ident: 37612_CR3 publication-title: Trends Cogn. Sci. doi: 10.1016/j.tics.2019.12.016 – volume-title: A functional Behavioristic Approach to Aversively Motivated Behavior: Predatory Imminence as a Determinant of the Topography Of Defensive Behavior year: 1988 ident: 37612_CR1 – volume: 100 start-page: 814 year: 1986 ident: 37612_CR41 publication-title: Behav. Neurosci. doi: 10.1037/0735-7044.100.6.814 – volume: 122 start-page: 282 year: 2008 ident: 37612_CR23 publication-title: Behav. Neurosci. doi: 10.1037/0735-7044.122.2.282 – volume: 16 start-page: 161 year: 1984 ident: 37612_CR37 publication-title: Hear Res. doi: 10.1016/0378-5955(84)90005-4 – volume: 985 start-page: 125 year: 2003 ident: 37612_CR10 publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2003.tb07077.x – volume: 328 start-page: 1398 year: 1993 ident: 37612_CR24 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199305133281907 – volume: 109 start-page: 2380 year: 2021 ident: 37612_CR8 publication-title: Neuron doi: 10.1016/j.neuron.2021.05.017 – volume: 67 start-page: 485 year: 2013 ident: 37612_CR43 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2012.11.025 – volume: 67 start-page: 370 year: 1969 ident: 37612_CR9 publication-title: J. Comp. Physiol. Psychol. doi: 10.1037/h0026779 – volume: 157 start-page: 291 year: 2005 ident: 37612_CR25 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2004.07.007 – volume: 11 start-page: 8215 year: 2021 ident: 37612_CR13 publication-title: Sci. Rep. doi: 10.1038/s41598-021-87559-3 – volume: 542 start-page: 96 year: 2017 ident: 37612_CR11 publication-title: Nature doi: 10.1038/nature21047 – volume: 11 start-page: e75663 year: 2022 ident: 37612_CR17 publication-title: Elife doi: 10.7554/eLife.75663 – volume: 1 start-page: 429 year: 1994 ident: 37612_CR2 publication-title: Psychon. Bull. Rev. doi: 10.3758/BF03210947 – volume: 10 start-page: 448 year: 1982 ident: 37612_CR18 publication-title: Anim. Learn. Behav. doi: 10.3758/BF03212284 – volume: 172 start-page: 294 year: 2006 ident: 37612_CR31 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2006.05.016 – volume: 9 start-page: e53803 year: 2020 ident: 37612_CR12 publication-title: Elife doi: 10.7554/eLife.53803 – volume: 264 start-page: 114146 year: 2023 ident: 37612_CR28 publication-title: Physiol. Behav. doi: 10.1016/j.physbeh.2023.114146 – volume: 56 start-page: 19 year: 2007 ident: 37612_CR6 publication-title: Neuron doi: 10.1016/j.neuron.2007.09.006 – volume: 563 start-page: 165 year: 1989 ident: 37612_CR38 publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1989.tb42197.x – volume: 13 start-page: 826783 year: 2022 ident: 37612_CR44 publication-title: Front. Pharmacol. doi: 10.3389/fphar.2022.826783 – volume: 4 start-page: e11352 year: 2015 ident: 37612_CR14 publication-title: Elife doi: 10.7554/eLife.11352 – volume: 389 start-page: 112623 year: 2020 ident: 37612_CR32 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2020.112623 – volume: 111 start-page: 855 year: 1997 ident: 37612_CR39 publication-title: Behav. Neurosci. doi: 10.1037/0735-7044.111.4.855 – volume: 65 start-page: 301 year: 2000 ident: 37612_CR40 publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(99)00216-6 – volume: 29 start-page: 171 year: 2022 ident: 37612_CR16 publication-title: Learn. Mem. doi: 10.1101/lm.053587.122 – volume: 49 start-page: 603 year: 1991 ident: 37612_CR42 publication-title: Physiol. Behav. doi: 10.1016/0031-9384(91)90286-W – volume: 14 start-page: 292 year: 2015 ident: 37612_CR27 publication-title: Genes Brain Behav. doi: 10.1111/gbb.12208 – volume: 11 start-page: e82711 year: 2022 ident: 37612_CR35 publication-title: Elife doi: 10.7554/eLife.82711 – volume: 23 start-page: 155 year: 2000 ident: 37612_CR5 publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.23.1.155 – volume: 53 start-page: 825 year: 1996 ident: 37612_CR30 publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/0091-3057(95)02084-5 – volume-title: Learning and Behavior: A Contemporary Synthesis year: 2007 ident: 37612_CR22 – volume: 12 start-page: 1040 year: 2021 ident: 37612_CR36 publication-title: Nat. Commun. doi: 10.1038/s41467-021-21248-7 – volume: 107 start-page: 289 year: 2000 ident: 37612_CR19 publication-title: Psychol. Rev. doi: 10.1037/0033-295X.107.2.289 – volume: 4 start-page: 29 year: 2010 ident: 37612_CR26 publication-title: Front. Behav. Neurosci. – volume-title: Handbook of Mouse Auditory Research year: 2001 ident: 37612_CR33 doi: 10.1201/9781420038736 |
| SSID | ssj0000529419 |
| Score | 2.4146132 |
| Snippet | Shifting defensive mode from one to another by the imminence of threat is crucial for survival. The transition of defensive mode from freezing to flight is... Abstract Shifting defensive mode from one to another by the imminence of threat is crucial for survival. The transition of defensive mode from freezing to... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 10402 |
| SubjectTerms | 631/378/1457 631/378/1595 Behavior Conditioned response Conditioned stimulus Defensive behavior Fear conditioning Flight Flight behavior Freezing Humanities and Social Sciences multidisciplinary Science Science (multidisciplinary) Tonic immobility Unconditioned stimulus |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEB1KoNBLaZp-uEmDArm1JrIky_IxDQlLID01kJuwLIkGgrd0N4f--8xI2k22X7nkamsX-emNZ2TNvAE4RFL0nvceVwDDN9UPbe2iISVMZEynYhw4FQpffNWzS3V-1V49aPVFOWFZHjgDd9QIPngZoh-iVh7_0bvYROFkNKTGlXbr6PMebKayqrfoVdOXKhkuzdECPRVVkwlJNkX5CBueKAn2_y3K_DNZ8rcT0-SIzl7ByxJBsuM88214FqbX8Dz3lPy1A7OLkiLISisdlrLRqa1VYMs5ize0HWer8vwFy4WKLCLlaai_Lp9o38Dl2em3k1ld2iXUo-bdsm7GIabCm6BF4xrXtiZyhyD1GnFSCNdg3Bja0UkXFbXiQyCiGD0fVE-R0lvYmuZTeA8soOeUqm28N0pRtiZ3qkPLNTrgi9p3FTQr6OxYtMSppcWNTWfa0tgMt0W4bYLb8go-rX_zIytp_Hf0F1qR9UhSwU4XkBu2cMM-xo0K9lbraYtpLiwpnmHcq5Ss4GB9G42KTkqGKcxv8xiN78IWn_RdXv71TGQndd-1ogKzQYyNqW7ema6_J-FuaulGMV0Fn1ccup_Xv7H48BRY7MILQeTnuhbdHmwtf96GjxhPLd1-Mp07uQ4aDA priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k3agozEDaI6fueEAFGtkMqJSnuz4tiGSlXSdrcH_j0zjpNqefSaOJEzD3vimfk-Qt6CUbSBtQE0AOGbbDtV-2QRCRMsxsiUOoaNwiff9OpUfl2rdTlw25SyynlNzAt1GHs8Iz9CoCoIV6QUHy4ua2SNwuxqodC4S-4hdBmWdJm1Wc5YMIslm7b0yjBhjzawX2FPGRfoWViVsLMfZdj-f8Waf5dM_pE3zdvR8SPysMSR9OOk-MfkThyekPsTs-Svp2R1UgoFaSHUobkmHcmtIt2ONJ3jTzmdm_Q3dGpXpAkMH4eGs3JQ-4ycHn_5_nlVF9KEutfMbOum71Juv4maN77xStnEPAeVaKtAM1x21vdR9V74JJGQDwSReB9YJ1uMl56TvWEc4ktCI-yfQqomBCsl1mwyLw34r9URlutgKtLMonN9QRRHYotzlzPbwrpJ3A7E7bK4HavIu-WZiwlP49bRn1Ajy0jEws4XxqsfrriWazjrgogpdEnLADYXfGoS9yJZxGuDlxzO-nTFQTfuxpwq8ma5Da6F-ZJuiOP1NEbDiqjgS19M6l9mIozQrVG8InbHMHamuntnOPuZ4buR2A0ju4q8n23oZl7_l8X-7Z9xQB5wNGuma24Oyd726jq-gnhp619np_gNwt0Qtw priority: 102 providerName: ProQuest – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Ni9UwEB_WFcGL-G11lQjetJjmq-lRHy4PYT25sLfQNIkuLH3LvrcH_3tn0rTydBW8ttOSzvwmmSYzvwF4g6DoAu8CWgDDN9X1uvbJEhMmIqZVKfWcCoVPvpj1qfp8ps8OQMy1MDlpP1Na5ml6zg57v8WFhorBhCSXoHSCW3CbqNsJ1SuzWvZV6ORKNV2pj-HS3vDo3hqUqfpvii__TJP87aw0L0HH9-FeiR3Zh2m0D-Agjg_hztRN8scjWJ-U5EBWmuiwnIdODa0i221YuqAfcTYX5m_ZVKLIEoKdRMN52Zx9DKfHn76u1nVplFAPhre7uhn6lEtuohGNb7zWNnEv0AzGarSGUL31Q9SDlz4pasKHikhiCLxXHcVIT-Bw3IzxGbCIa6ZUugnBKkV5mtyrFn3WmohTdGgraGbVuaGwiFMziwuXT7OldZO6HarbZXU7XsHb5ZnLiUPjn9IfySKLJPFf5wubq2-u4ME1gvdBxhT6ZFRAnAWfmiS8TJY42vAlR7M9XXHKrSOuM4x4lZIVvF5uozvRGUk_xs31JGNwFtT4pU8n8y8jka00XatFBXYPGHtD3b8znn_PlN3UzI2iuQrezRj6Na6_6-L5_4m_gLuCYM5NLdojONxdXceXGDPt_KvsJD8BNSMOmQ priority: 102 providerName: Springer Nature |
| Title | Multiple factors contribute to flight behaviors during fear conditioning |
| URI | https://link.springer.com/article/10.1038/s41598-023-37612-0 https://www.ncbi.nlm.nih.gov/pubmed/37369752 https://www.proquest.com/docview/2830013443 https://www.proquest.com/docview/2830670357 https://pubmed.ncbi.nlm.nih.gov/PMC10300071 https://doaj.org/article/120ad3efdaf64d208dbf1f2b3f824850 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3di9NAEB_uA-VexG-jZ4ngm0aTzWZ38yDSK3eUQg9RC30L2eyuHpRU2x54_70zm02l2vMpkGzCZj4ys9mZ3w_gNRpFadLSoAYwfeNlXSTaKULCRIuR3Lk6pUbh6aUYz_hkXswPoKc7CgJc713aEZ_UbLV49-vnzUd0-A9dy7h6v8YgRI1iLCd3oVKDQzjGyCTJUach3e-wvlnJszL0zuy_9QTu5jIXpSzYTqjyiP770tB_qyn_2lL1keriPtwLKWY87GziARzY9iHc6Ugnbx7BeBpqCOPAtRP7cnXivbLxZhm7Ba3X475_fx13nYyxQ5-goeYq_MN9DLOL86-jcRL4FJJGpHKTZE3tfGeOFSzTmS4K5VLNUFtCFag0xmulG1s0OteOE1cfysSxxqQ1LymVegJH7bK1zyC2GFpzXmTGKM6pnDPVXKJrK2HxS25kBFkvuqoJYOPEebGo_KZ3rqpO8hVKvvKSr9II3mzv-dFBbfx39BlpZDuSYLL9ieXqWxW8rspYWpvcOlM7wQ2ao9Euc0znThGUGz7ktNdn1ZteRZBomBhznkfwansZvY62UurWLq-7MQI_lgW-6dNO_duZ9OYTgdoxjJ2p7l5pr757ZG_ifKOkL4K3vQ39mdftsnh-6xxewAkj405FwuQpHG1W1_YlZlEbPYBDOZcDOB4OJ18meDw7v_z0Gc-OxGjg_0wMvPP8BhvDGcI |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrRC9IN4EChgJThA1sZ3EOSBEodWWdlcItVJvJo5tWqnKlu5WqH-K38hM4qRaHr31mjiRM-94Hh_AKxSK0ialRQ5g-CbLKouNVzQJEyWmkN5XCTUKT6b5-EB-PswOV-BX3wtDZZW9TWwNtZ3VdEa-QYOqMFyRUrw__RETahRlV3sIjU4sdt3FT_xlm7_b-YT8fc359tb-x3EcUAXiOk-KRZzWlW_7U1zOU5OaLFM-MRz3nKsMt85lpUztstoI4yUh1qEOel7bpJIlBRT43huwKgX-yoxgdXNr-uXrcKpDeTOZlqE7JxFqY44ekrrYuCBdpjqIJQ_YAgX8K7r9u0jzj0xt6wC378DtELmyD52o3YUV19yDmx2W5cV9GE9CaSILED6srYInOC3HFjPmT-gYgPVjAeasa5BkHmlKS-1xOBp-AAfXQtCHMGpmjXsMzKHHFjJLrVVSUpVoYmSBFkPlDh2ELSJIe9LpOswwJyiNE93m0oXSHbk1klu35NZJBG-GZ067CR5Xrt4kjgwrafp2e2F29l0HZdYpTyornLeVz6VFKbfGp54b4RVNiMOXrPf81MEkzPWlAEfwcriNykwZmqpxs_NuTY42OMMvfdSxf9iJKEReFhmPQC0JxtJWl-80x0ftwHCCkqNYMoK3vQxd7uv_tHhy9We8gFvj_cme3tuZ7j6FNU4inuQxL9ZhtDg7d88wWluY50FFGHy7bq38DUJ-TRo |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLZKEYhLxVoCBYIEJ4jG8RI7B4SAMppSWnGg0txMHNtQqUpKZ6qqf41fx3vOUg1Lb71OnMh--_gtHyEvQChKR0sHHIDwTZSVzGzQOAkTJEaJECqKjcJ7-8XsQHyay_ka-TX0wmBZ5WATo6F2bY135BMcVAXhihB8EvqyiC_b07fHPzNEkMJM6wCn0YnIrj8_g79vizc728Drl4xNP379MMt6hIGsLqhaZnldhdir4guW29xKqQO1DPZfaAnHYKLStvayttwGgeh1oI-B1Y5WosTgAr57jVxXXOaoY2quxvsdzKCJvOz7dCjXkwX4SuxnYxy1GisiVnxhhAz4V5z7d7nmHznb6Aqnt8lGH8Om7zqhu0PWfHOX3OhQLc_vkdleX6SY9mA-aayHR2Atny7bNBzhhUA6DAhYpF2rZBqAorjUHfaXxPfJwZWQ8wFZb9rGPySpB9_Nhcyd00JgvSi1QoHt0IUHV-FUQvKBdKbup5kjqMaRiVl1rk1HbgPkNpHchibk1fjOcTfL49LV75Ej40qcwx1_aE--m16tTc5o5bgPrgqFcCDvzoY8MMuDxllx8JGtgZ-mNw4LcyHKCXk-Pga1xlxN1fj2tFtTgDWWcNLNjv3jTrjiRakkS4heEYyVra4-aQ5_xNHhCCqHUWVCXg8ydLGv_9Pi0eXHeEZugi6azzv7u4_JLYYSTouMqS2yvjw59U8gbFvap1E_UvLtqhXyN0S_T-o |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Multiple+factors+contribute+to+flight+behaviors+during+fear+conditioning&rft.jtitle=Scientific+reports&rft.au=Furuyama%2C+Takafumi&rft.au=Imayoshi%2C+Ayana&rft.au=Iyobe%2C+Toyo&rft.au=Ono%2C+Munenori&rft.date=2023-06-27&rft.eissn=2045-2322&rft.volume=13&rft.issue=1&rft.spage=10402&rft_id=info:doi/10.1038%2Fs41598-023-37612-0&rft_id=info%3Apmid%2F37369752&rft.externalDocID=37369752 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |