Polyunsaturated fatty acids-rich dietary lipid prevents high fat diet-induced obesity in mice

• Published in: Scientific reports Vol. 13; no. 1; pp. 5556 - 10
• Main Authors: Haneishi, Yuri, Furuya, Yuma, Hasegawa, Mayu, Takemae, Hitoshi, Tanioka, Yuri, Mizutani, Tetsuya, Rossi, Mauro, Miyamoto, Junki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.04.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/45; 692/163; 692/4020; Animals; Diet; Diet, High-Fat - adverse effects; Dietary Fats - pharmacology; Dietary intake; Energy balance; Fat metabolism; Fatty acids; Fatty Acids, Unsaturated - adverse effects; Food intake; Glucose tolerance; High fat diet; Homeostasis; Humanities and Social Sciences; Inflammation - metabolism; Intestinal microflora; Lipid Metabolism; Lipids; Metabolic disorders; Metabolism; Mice; Mice, Inbred C57BL; Microbiota; multidisciplinary; Obesity; Obesity - metabolism; Polyunsaturated fatty acids; Science; Science (multidisciplinary)

Diet is the primary factor affecting host nutrition and metabolism, with excess food intake, especially high-calorie diets, such as high-fat and high-sugar diets, causing an increased risk of obesity and related disorders. Obesity alters the gut microbial composition and reduces microbial diversity...