Lever-press duration as a measure of frustration in sucrose and drug reinforcement

• Published in: Psychopharmacology Vol. 238; no. 4; pp. 959 - 968
• Main Authors: Vasquez, Tileena E. S., McAuley, Ryan J., Gupta, Nikita S., Koshy, Shyny, Marmol-Contreras, Yorkiris, Green, Thomas A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2021; Springer; Springer Nature B.V
• Subjects: Addictions; Analysis; Animals; Behavior; Behavior, Addictive; Biomedical and Life Sciences; Biomedicine; Cocaine; Cocaine - administration & dosage; Conditioning, Operant; Craving; Drug abuse; Drug self-administration; Drug tolerance; Drug use; Fentanyl; Frustration; Impulsive behavior; Male; Measurement; Neurosciences; Original Investigation; Pharmacology/Toxicology; Psychiatry; Rats; Rats, Sprague-Dawley; Reinforcement; Reinforcement, Psychology; Reward; Self Administration; Sucrose; Sucrose - administration & dosage; Time perception in animals; United States; Opioid; Drug abuse; Stimulant; Aggression related; Progressive ratio; Escalation

Rationale Currently there is little research into the role of frustration in substance use disorders despite research showing that frustration tolerance in humans is associated with a lower likelihood of developing substance use problems, better outcomes in recovery, and fewer relapses. Objective In...