Effect of the combination of photobiomodulation therapy and the intralesional administration of corticoid in the preoperative and postoperative periods of keloid surgery: A randomized, controlled, double-blind trial protocol study

• Published in: PloS one Vol. 17; no. 2; p. e0263453
• Main Authors: Pires, Jefferson André, Bragato, Erick Frank, Momolli, Marcos, Guerra, Marina Bertoni, Neves, Leonel Manea, de Oliveira Bruscagnin, Meire Augusto, Ratto Tempestini Horliana, Anna Carolina, Porta Santos Fernandes, Kristianne, Kalil Bussadori, Sandra, Agnelli Mesquita Ferrari, Raquel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.02.2022; Public Library of Science (PLoS)
• Subjects: Adrenal Cortex Hormones - administration & dosage; Adrenal Cortex Hormones - pharmacology; Adult; Biology and Life Sciences; Care and treatment; Cell division; Clinical trials; Collagen; Combined Modality Therapy; Corticosteroids; Dehydrogenases; Dermis; Double-Blind Method; Double-blind studies; Female; Fibroblasts; Growth factors; Health aspects; Health sciences; Humans; Injections, Intralesional; Keloid - metabolism; Keloid - psychology; Keloid - therapy; Keloids; Light; Light therapy; Low-Level Light Therapy - methods; Male; Medicine and Health Sciences; Middle Aged; Monochromatic light; Patient outcomes; Patient Satisfaction - statistics & numerical data; Physical Sciences; Plastic surgery; Postoperative Care; Preoperative Care; Prospective Studies; Quality assessment; Quality of life; Quality of Life - psychology; Questionnaires; Registered Report Protocol; Scars; Silicones; Statistical analysis; Statistical analysis of data; Surgery; Testing; Transforming Growth Factor beta - metabolism; Treatment Outcome; Triamcinolone Acetonide - administration & dosage; Triamcinolone Acetonide - analogs & derivatives; Triamcinolone Acetonide - pharmacology; Young Adult; Brazil

Keloid scars are characterized by the excessive proliferation of fibroblasts and an imbalance between the production and degradation of collagen, leading to its buildup in the dermis. There is no “gold standard” treatment for this condition, and the recurrence is frequent after surgical procedures r...