Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation

Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is ge...

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Published inHippocampus Vol. 30; no. 6; pp. 545 - 564
Main Authors Flores, Robin, Berron, David, Ding, Song‐Lin, Ittyerah, Ranjit, Pluta, John B., Xie, Long, Adler, Daniel H., Robinson, John L., Schuck, Theresa, Trojanowski, John Q., Grossman, Murray, Liu, Weixia, Pickup, Stephen, Das, Sandhitsu R., Wolk, David A., Yushkevich, Paul A., Wisse, Laura E. M.
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.06.2020
Wiley Subscription Services, Inc
Subjects
Aging
Anatomy
Autopsy
Clinical Medicine
Cognition
Dementia disorders
Dentate gyrus
Engineering and Technology
ex vivo
hippocampal subfields
Hippocampus
histology
Image processing
in vivo
Klinisk medicin
Magnetic resonance imaging
Medical and Health Sciences
Medical Engineering
Medical Image Processing
Medical Imaging
Medicin och hälsovetenskap
Medicinsk bildbehandling
Medicinsk bildvetenskap
Medicinteknik
MRI
Radiologi och bildbehandling
Radiology and Medical Imaging
Radiology, Nuclear Medicine and Medical Imaging
Segmentation
Subiculum
Tails
Teknik
segmentation
in vivo
hippocampal subfields
histology
ex vivo
MRI
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Abstract Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a postmortem dataset containing nine specimens of subjects with and without dementia, which underwent a 9.4 T MRI and histological processing. Postmortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered annotated histological sections. We focus on the following topics: the order of appearance of subfields, the location of subfields relative to macroanatomical features, the location of subfields in the uncus and tail and the composition of the dark band, a hypointense layer visible in T2‐weighted MRI. Our main findings are that: (a) there is a consistent order of appearance of subfields in the hippocampal head, (b) the composition of subfields is not consistent in the anterior uncus, but more consistent in the posterior uncus, (c) the dark band consists only of the CA‐stratum lacunosum moleculare, not the strata moleculare of the dentate gyrus, (d) the subiculum/CA1 border is located at the middle of the width of the hippocampus in the body in coronal plane, but moves in a medial direction from anterior to posterior, and (e) the variable location and composition of subfields in the hippocampal tail can be brought back to a body‐like appearance when reslicing the MRI scan following the curvature of the tail. Our findings and this publicly available dataset will hopefully improve anatomical accuracy of future hippocampal subfield segmentation protocols.
AbstractList Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a postmortem dataset containing nine specimens of subjects with and without dementia, which underwent a 9.4 T MRI and histological processing. Postmortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered annotated histological sections. We focus on the following topics: the order of appearance of subfields, the location of subfields relative to macroanatomical features, the location of subfields in the uncus and tail and the composition of the dark band, a hypointense layer visible in T2-weighted MRI. Our main findings are that: (a) there is a consistent order of appearance of subfields in the hippocampal head, (b) the composition of subfields is not consistent in the anterior uncus, but more consistent in the posterior uncus, (c) the dark band consists only of the CA-stratum lacunosum moleculare, not the strata moleculare of the dentate gyrus, (d) the subiculum/CA1 border is located at the middle of the width of the hippocampus in the body in coronal plane, but moves in a medial direction from anterior to posterior, and (e) the variable location and composition of subfields in the hippocampal tail can be brought back to a body-like appearance when reslicing the MRI scan following the curvature of the tail. Our findings and this publicly available dataset will hopefully improve anatomical accuracy of future hippocampal subfield segmentation protocols.Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a postmortem dataset containing nine specimens of subjects with and without dementia, which underwent a 9.4 T MRI and histological processing. Postmortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered annotated histological sections. We focus on the following topics: the order of appearance of subfields, the location of subfields relative to macroanatomical features, the location of subfields in the uncus and tail and the composition of the dark band, a hypointense layer visible in T2-weighted MRI. Our main findings are that: (a) there is a consistent order of appearance of subfields in the hippocampal head, (b) the composition of subfields is not consistent in the anterior uncus, but more consistent in the posterior uncus, (c) the dark band consists only of the CA-stratum lacunosum moleculare, not the strata moleculare of the dentate gyrus, (d) the subiculum/CA1 border is located at the middle of the width of the hippocampus in the body in coronal plane, but moves in a medial direction from anterior to posterior, and (e) the variable location and composition of subfields in the hippocampal tail can be brought back to a body-like appearance when reslicing the MRI scan following the curvature of the tail. Our findings and this publicly available dataset will hopefully improve anatomical accuracy of future hippocampal subfield segmentation protocols.
Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a postmortem dataset containing nine specimens of subjects with and without dementia, which underwent a 9.4 T MRI and histological processing. Postmortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered annotated histological sections. We focus on the following topics: the order of appearance of subfields, the location of subfields relative to macroanatomical features, the location of subfields in the uncus and tail and the composition of the dark band, a hypointense layer visible in T2‐weighted MRI. Our main findings are that: (a) there is a consistent order of appearance of subfields in the hippocampal head, (b) the composition of subfields is not consistent in the anterior uncus, but more consistent in the posterior uncus, (c) the dark band consists only of the CA‐stratum lacunosum moleculare, not the strata moleculare of the dentate gyrus, (d) the subiculum/CA1 border is located at the middle of the width of the hippocampus in the body in coronal plane, but moves in a medial direction from anterior to posterior, and (e) the variable location and composition of subfields in the hippocampal tail can be brought back to a body‐like appearance when reslicing the MRI scan following the curvature of the tail. Our findings and this publicly available dataset will hopefully improve anatomical accuracy of future hippocampal subfield segmentation protocols.
Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a post-mortem dataset containing 9 specimens of subjects with and without dementia, which underwent a 9.4 tesla MRI and histological processing. Post-mortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered annotated histological sections. We focus on the following topics: the order of appearance of subfields, the location of subfields relative to macroanatomical features, the location of subfields in the uncus and tail and the composition of the dark bank, a hypointense layer visible in T2-weighted MRI. Our main findings are that: 1) there is a consistent order of appearance of subfields in the hippocampal head, 2) the composition of subfields is not consistent in the anterior uncus, but more consistent in the posterior uncus, 3) the dark band consists only of the CA-stratum lacunosum moleculare, not the strata moleculare of the dentate gyrus, 4) the subiculum/CA1 border is located at the middle of the width of the hippocampus in the body in coronal plane, but moves in a medial direction from anterior to posterior, and 5) the variable location and composition of subfields in the hippocampal tail can be brought back to a body-like appearance when reslicing the MRI scan following the curvature of the tail. Our findings and this publicly available dataset will hopefully improve anatomical accuracy of future hippocampal subfield segmentation protocols.
Author Pluta, John B.
Trojanowski, John Q.
Wolk, David A.
Robinson, John L.
Adler, Daniel H.
Pickup, Stephen
Berron, David
Flores, Robin
Wisse, Laura E. M.
Grossman, Murray
Yushkevich, Paul A.
Das, Sandhitsu R.
Xie, Long
Ittyerah, Ranjit
Liu, Weixia
Schuck, Theresa
Ding, Song‐Lin
AuthorAffiliation e Institute of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China
b Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104
f Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA 19104
a Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104
c Penn Memory Center, University of Pennsylvania, Philadelphia, PA 19104
g Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden
d Allen Institute for Brain Science, Seattle, WA 98109
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Issue 6
Keywords segmentation
in vivo
hippocampal subfields
histology
ex vivo
MRI
Language English
License 2019 Wiley Periodicals, Inc.
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BrightFocus Foundation; Fondation Philippe Chatrier; National Institutes of Health, Grant/Award Numbers: P30 AG010124, R01 AG055005, R01 AG056014
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Snippet Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have...
Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging and disease research. Extant subfield segmentation protocols have...
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SubjectTerms Aging
Anatomy
Autopsy
Clinical Medicine
Cognition
Dementia disorders
Dentate gyrus
Engineering and Technology
ex vivo
hippocampal subfields
Hippocampus
histology
Image processing
in vivo
Klinisk medicin
Magnetic resonance imaging
Medical and Health Sciences
Medical Engineering
Medical Image Processing
Medical Imaging
Medicin och hälsovetenskap
Medicinsk bildbehandling
Medicinsk bildvetenskap
Medicinteknik
MRI
Radiologi och bildbehandling
Radiology and Medical Imaging
Radiology, Nuclear Medicine and Medical Imaging
Segmentation
Subiculum
Tails
Teknik
Title Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhipo.23172
https://www.ncbi.nlm.nih.gov/pubmed/31675165
https://www.proquest.com/docview/2410516747
https://www.proquest.com/docview/2311637951
https://pubmed.ncbi.nlm.nih.gov/PMC7192771
https://lup.lub.lu.se/record/24d11f6d-ca9a-4cd7-99b5-6d6e3c536094
oai:portal.research.lu.se:publications/24d11f6d-ca9a-4cd7-99b5-6d6e3c536094
Volume 30
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