Direct regulation of transforming growth factor β‐induced epithelial–mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells

• Published in: Cancer science Vol. 106; no. 12; pp. 1693 - 1704
• Main Authors: Kusunose, Masaaki, Hashimoto, Naozumi, Kimura, Motohiro, Ogata, Ryo, Aoyama, Daisuke, Sakamoto, Koji, Miyazaki, Shinichi, Ando, Akira, Omote, Norihito, Imaizumi, Kazuyoshi, Kawabe, Tsutomu, Hasegawa, Yoshinori
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2015; John Wiley and Sons Inc
• Subjects: Blotting, Western; Cell Line, Tumor; Chromosome 10; Cytoplasm; Enzymatic activity; Epithelial-Mesenchymal Transition - physiology; epithelial–mesenchymal transition; Fluorescent Antibody Technique; Gene expression; Growth factors; Humans; Lipids; Lung cancer; Lung Neoplasms - pathology; Mesenchyme; Microscopy, Confocal; Original; Phosphatase; Phosphates; Phosphoprotein Phosphatases - metabolism; Phosphorylation; Protein phosphatase; protein phosphatase activity; Proteins; PTEN; PTEN Phosphohydrolase - metabolism; PTEN protein; Signal transduction; Studies; Tensin; Therapeutic applications; Transfection; Transforming growth factor; Transforming Growth Factor beta - metabolism; transforming growth factor β; Transforming growth factor-b; Tumor suppressor genes; β‐Catenin; United Kingdom > UK; United States > US; Japan; PTEN; β-Catenin; epithelial-mesenchymal transition; protein phosphatase activity; transforming growth factor β

Transforming growth factor β (TGFβ) causes the acquisition of epithelial–mesenchymal transition (EMT). Although the tumor suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) can negatively regulate many signaling pathways activated by TGFβ, hyperactivation of these sig...